Cracking the histone code: one, two, three methyls, you're out!

Robert N Dutnall

doi:10.1016/s1097-2765(03)00282-x

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Cracking the histone code: one, two, three methyls, you're out!

Robert N Dutnall

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Abstract

In this issue of Molecular Cell, Zhang et al. report the structure of a ternary complex between the SET domain histone methyltransferase DIM-5, its cofactor, and a histone H3 peptide. The insight gained from analysis of a key amino acid provides an exciting opportunity to dissect the possible functional meaning of mono-, di-, and trimethylation of histone lysine residues in vivo that will complement existing approaches in the quest to crack the histone methylation code.

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Amino Acid Sequence Animals Catalytic Domain Cell Nucleus Eukaryotic Cells Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Humans Lysine Macromolecular Substances Methylation Methyltransferases Protein Methyltransferases Journal Article Review Comment

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Robert N Dutnall. 2003. Cracking the histone code: one, two, three methyls, you're out!. https://doi.org/10.1016/s1097-2765(03)00282-x

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