Biomedical subjects

Rongjun He

Publications and source records attributed to Rongjun He.

2 recordsLinked to original sources

PubMedDate not supplied

A highly efficient solid-phase synthesis of 1,3-substituted xanthines.

A first solid-phase route to 1,3-substituted xanthines has been developed using PS-MB-CHO resin. Cyclocondensation of the polymer-bound aminoimidazole with isocyanates followed by alkylation provided 1,3-substituted xanthines in high yields. Libraries of 12 xanthines and 4 thioxanthines were prepared.

Journal Article↗

PubMedDate not supplied

Traceless solid-phase synthesis of substituted xanthines.

A traceless solid-phase route to substituted xanthines, based on the late-stage pyrimidine ring closure, has been developed. This method is especially useful for the preparation of xanthines containing a variety of substituents at the N1, N3, N7, and C8 positions in an unambiguous manner. A representative set of 22 compounds was prepared.

Combinatorial Chemistry Techniques↗