Traceless solid-phase synthesis of substituted xanthines.

Rongjun He; Shi Min Ching; Yulin Lam

doi:10.1021/cc060092+

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PubMed · 17096582

Traceless solid-phase synthesis of substituted xanthines.

Rongjun He·Shi Min Ching·Yulin Lam

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Abstract

A traceless solid-phase route to substituted xanthines, based on the late-stage pyrimidine ring closure, has been developed. This method is especially useful for the preparation of xanthines containing a variety of substituents at the N1, N3, N7, and C8 positions in an unambiguous manner. A representative set of 22 compounds was prepared.

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Combinatorial Chemistry Techniques Molecular Structure Solutions Stereoisomerism Xanthines Journal Article Research Support, Non-U.S. Gov't

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Rongjun He, Shi Min Ching, Yulin Lam. Traceless solid-phase synthesis of substituted xanthines.. https://doi.org/10.1021/cc060092%2B

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