PubMed Health⌕ Search

Biomedical subjects

S A Said

Publications and source records attributed to S A Said.

At least 19 recordsLinked to original sources
PubMed2006

Experimental investigation and nuclear model calculations on proton-induced reactions on highly enriched 114Cd at low energies.

The excitation functions of both Cd(p,n)(114m)In114 and Cd(p,2n)(113m)In114 reactions were evaluated experimentally by the stacked-foil technique on highly enriched (114)Cd isotope. Two stacks were irradiated by proton beam with energies 14.7 and 18MeV on the MGC-20 cyclotron at Nuclear Research Center, AEA, Egypt. The present results support the previous measurements. The theoretical interpretations of the measured excitation functions were done by EMPIRE-II (v2.18 Mondovi) code. Compatibility with predictions of hybrid Monte Carlo simulation (HMS) pre-equilibrium mechanism was obtained.

Journal Article↗
PubMed1999

Acquired coronary cameral fistulas: are these collaterals losing their destination?

BACKGROUND: The majority of coronary cameral fistulas (CCFs) are congenital in origin. On the other hand, acquired coronary cameral fistulas, having various etiopathogenic origins, are increasingly recognized. HYPOTHESIS: The aim of this study was to assess the possible involvement of coronary atherosclerosis in the pathogenesis of acquired coronary cameral fistulas. METHODS: Between 1993 and 1996 coronary cameral fistulas were detected in seven adults patients with coronary atherosclerosis (n = 4) and following myocardial infarction (n = 3) with a mean age of 59.3 years (range 40-77). They were analyzed at our hospital. RESULTS: Myocardial infarction (MI) was documented in six patients and was localized at the same territory of the fistula-related artery in three of them. All patients remained asymptomatic after the detection of the fistula. Five patients had associated cardiac disorders. Two patients were treated conservatively with medical therapy. Coronary artery bypass grafting (CABG) was performed in three patients. One patient died while awaiting CABG. Thirty-four adult cases with acquired CCFs were collected from the current literature. The right coronary artery was the origin of the fistula in 37% and they terminated into the right heart-side in 72% of cases. They remained asymptomatic in 62% of cases. CONCLUSIONS: It could be concluded that acquired CCFs may complicate the course of severe atherosclerosis or myocardial infarction in certain adult patients. The symptomatology and treatment strategy is comparable in the congenital and acquired types. The distribution of involvement of the right or left coronary arteries is equally divided in both the acquired and congenital types. Further studies are needed to investigate the precipitating factors for the occurrence of and incidence of acquired CCFs in patients with severe atherosclerosis or post-MI subjects.

Adult↗
PubMed1998

A soccer victim: late rupture of the ascending aorta after violent physical trauma.

A 56-year-old man without previous medical history or risk factors for coronary artery disease, presented with chest pain 2 weeks after violent blunt chest trauma. He was as a spectator, beaten and kicked almost to death during an amateur soccer match. Because of embarrassment, this was denied till shortly after his death. Shortly before the patient died, thoracic CT-scan showed a dissecting aneurysm of the ascending aorta in association with pericardial and bilateral pleural effusion. He suddenly died in-hospital due to heart tamponade secondary to rupture of the aneurysm into the pericardial space. At autopsy, the intimal layer of the aorta showed no atherosclerotic changes. The intimal rupture was located just above the origin of the right coronary artery.

Aortic Dissection↗
PubMed1998

Role of endogenous endothelin-1 in stress-induced gastric mucosal damage and acid secretion in rats.

In rats subjected to 8 h water-immersion stress, gastric and duodenal mucosal hemorrhage and erosions were detected by macroscopic and histopathological examination. Moreover, plasma and gastric mucosal endothelin-1 (ET-1) levels rose appreciably in a time-related manner during water immersion, with a higher concentration detected in gastric mucosa. Thus, the percentage increases in plasma (gastric mucosal) ET-1, relative to basal levels, after 1, 4 and 8 h of water immersion were 86(172), 169(322) and 210(391)%, respectively. Likewise, a marked increase of gastric acid output was demonstrated 30 min after water immersion and lasted for 3 h. Pretreatment with the endothelin ET(A)/ET(B) receptor blocker, bosentan (30 and 100 mg kg(-1)), orally, dose-dependently antagonized gastric and duodenal mucosal damage as indicated by reductions in lesion lengths of 67 and 80%, respectively. Similar protective effects on mucosa were observed when bosentan was given by the intramuscular route. On the other hand, bosentan suppressed the rate of acid output by 30.3+/-2.1% in the stressed rats, but had no such effect in non-stressed animals. Taken together, results from this study implicate the endogenous peptide, ET-1, as a powerful mediator of stress-evoked gastro-duodenal mucosal damage and, moreover, present bosentan as a potential protector against hyperacidity and mucosal erosion that occur as a consequence of stress.

Animals↗
PubMed1998

Acute nonrheumatic myopericarditis associated with group A hemolytic streptococcal tonsillitis in a male ICU-nurse.

We present the case of a 38-year-old man who developed acute myopericarditis, mimicking acute myocardial infarction, as manifested by electrocardiographic, echocardiographic alterations and elevated cardiac enzymes complicating Lancefield group A beta-hemolytic streptococcal tonsillitis. After receiving oral penicillin, the clinical recovery was complete. Fever, tachycardia and chest discomfort resolved within a few days. Furthermore, enzyme levels and C-reactive protein returned to normal within eight days.

Acute Disease↗
PubMed1997

Ventriculo-venous communications in adults: ventriculographic observations in two female patients.

Ventriculo-venous communications (VVC) were angiographically demonstrated in two adult female patients clinically presented with effort angina. During oxymetric studies there were minor to moderate left-to-right shunts. Concomitant, mild valvular aortic stenosis (AS) was present in one patient and hypertrophic obstructive cardiomyopathy (HOCM) in the other. It is believed that ventriculo-venous communications have contributed to the symptomatology in both patients. Symptoms were controlled medically in combination with dual (DDD) cardiac pacing with short AV-delay in one patient and only medically in the other patient. From the differential diagnostic point of view, superselective contrast injection into an 'inert' myocardial sinusoid or intramural contrast staining has been considered but could be excluded.

Aged↗
PubMed1997

Coronary arteriovenous fistulas: collective review and management of six new cases--changing etiology, presentation, and treatment strategy.

We considered it worthwhile to review the literature of the last decade (1985-1995) to answer the question whether the etiology and the clinical picture of coronary arteriovenous fistulas (CAVFs) have changed. Furthermore, new therapeutic modalities such as percutaneous transcatheter embolization have been developed. We tried to define the place of these techniques in the therapeutic arena. Clinical presentation and management of six patients with eight congenital CAVFs and 76 subjects with 96 congenital and acquire I CAVFs taken from a review of the recent literature are presented. Sixty-three review subjects (78%) were treated medically with one fatal case. Ligation of the fistula was achieved by surgical techniques in 10% of review subjects, while percutaneous transcatheter embolization (PTE) was performed in nine patients (12%). Percutaneous transcatheter embolization techniques are being increasingly used in the treatment of CAVFs. The etiology of CAVFs has a tendency to show alterations toward the acquired pathogenesis. In 64% of the review subjects the fistula was congenital in origin, and in 36% it had an acquired cause. Among the patients of the current review, the clinical presentations were 55% asymptomatic, 34% chest pain (anginal or atypical), and 13% congestive heart failure. The CAVFs of our six patients are all congenital in origin. In the current review, the clinical presentation showed a trend toward increasing chest complaints (34%) compared with the review (10%) published in the mid 1970s. This may be due to a higher mean age, and hence increased concurrent coronary artery disease due to aging compared with the review population of two decades ago.

Adolescent↗
PubMed1997

Takayasu's arteritis: a rare cause of cardiac death in a Caucasian teenage female patient.

A caucasian teenage Dutch schoolgirl with known chronic low visual acuity and albinism, presented with frank acute pulmonary oedema, died after 1 h of cardio-pulmonary resuscitation for bradyarrhythmia and cardiac arrest. Two weeks prior to presentation, during sport training, she complained of oppressive chest pain on exertion accompanied with vomiting without any other systemic symptoms. Post-mortem examination revealed supravalvular stenosis of the pulmonary trunk and ascending aorta with irregular intimal thickening associated with stenosis of the left coronary artery. Microscopic examination demonstrated cellular infiltration of the wall of the aorta and pulmonary trunk with formation of granulomas with multinucleated giant cells. These features are compatible with Takayasu's arteritis.

Adolescent↗
PubMed1996

Effect of praziquantel on serum glucose and insulin levels in normal and hyperglycemic rats.

The effects of praziquantel (CAS 55268-74-1) on serum glucose and insulin levels in normoglycemic and hyperglycemic rats were studied. Also the combined effect of praziquantel and glibenclamide (CAS 10238-21-8) on oral glucose tolerance in rats was investigated. Praziquantel, given orally in a dose of 250 mg/kg, significantly increased serum glucose level in hyperglycemic rats without changing serum insulin level. After oral glucose load, praziquantel produced a significant increase in serum glucose level and antagonized the hypoglycemic action of glibenclamide. These results indicate that praziquantel significantly increased serum glucose level in both hyperglycemic rats and after glucose load. Since insulin levels are not significantly altered by praziquantel, the hyperglycemic effect of this drug may be attributed to inhibition of peripheral glucose utilization. Care should be taken if praziquantel is prescribed to diabetic patients.

Animals↗
PubMed1995

Coronary angiographic morphology of congenital coronary arteriovenous fistulas in adults: report of four new cases and review of angiograms of fifteen reported cases.

The coronary angiographic features of four new cases of congenital coronary arteriovenous fistulas (CAVFs) are described, and the angiograms of 15 reported cases are reviewed. The morphologic appearance of CAVFs varied from a small discrete single channel to a highly complex plexiform network with a maze of fine vessels. The majority of CAVFs in our series were composed of a single channel. Aneurysmal formation was present in 26% (6/23). Aneurysmal formation involved only the pathway and/or the termination, but never originated from the beginning of the CAVFs.

Adult↗
PubMed1994

Flecainide-induced JT prolongation, T wave inversion and ventricular tachycardia during treatment for symptomatic atrial fibrillation.

Two hours after taking 100 mg of flecainide, a patient developed gastrointestinal complaints, dizziness and shortness of breath. The ECG demonstrated novel prolonged JT interval with negative T wave in the precordial leads. During admission, several attacks of non-sustained ventricular tachycardia occurred. The plasma drug concentration was 814 mg/l. Although the tachycardia was non-sustained, cardiovascular collapse developed. Serum electrolytes were normal and myocardial infarction was excluded. The patient is now free of symptoms without medications.

Aged↗
PubMed1993

Congenital coronary arteriovenous fistula associated with atrioventricular valvular regurgitation in an octogenarian.

An arteriovenous fistula originating from halfway down the circumflex coronary artery, draining into the coronary sinus was first diagnosed in a patient of 81. For 10 years, she had had dyspnea on exertion, mild mitral regurgitation and permanent ventricular pacing for symptomatic bradyarrhythmia. She was treated medically and despite her age was offered transcatheter balloon embolization, but she refused to undergo such intervention.

Aged↗
PubMed1993

Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.

Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure. Her antecedent medical history included stable, mild renal function impairment, mitral regurgitation, atrial fibrillation, recurrent transient ischaemic attacks and cholelithiasis. The drugs concomitantly used were digoxin, isosorbide dinitrate, frusemide, urapidil and chlorthalidone in conjunction with oral potassium substitution. Upon withdrawal of ibopamine but continuation of all other drugs, the patient recovered from the blood dyscrasia within 5 days and showed resolution of symptoms. Measurements of protected isolation and selective intestinal decontamination were taken. No complications resulting from secondary infection occurred. After withdrawal of ibopamine and under continuation of all other concomitant medications her body weight continued to decrease during the following few days, her symptoms were alleviated and she was discharge to a nursing home.

Aged↗
PubMed1992

Coronary-cameral fistula in association with Klinefelter syndrome: exercise-induced ventricular tachycardia late after surgical ligation.

Twenty two years after surgical ligation of a large coronary-cameral fistula originating from the circumflex artery and terminating to the right atrium, non-sustained exercise-induced ventricular tachycardia occurred in a 26-year-old male with known Klinefelter (XXY) syndrome. Cardiac catheterization showed satisfactory closure of the defect, but also revealed occlusion of the circumflex coronary artery, associated with inferolateral infarction.

Adult↗
PubMed1992

Stress MIBI scintigraphy in multiple coronary-pulmonary fistula: failure to demonstrate "steal" phenomenon.

Stress radionuclide studies were performed in a patient with angiographically proven multiple coronary-pulmonary fistulas, in the presence of atypical chest pain. MIBI scintigraphy showed no myocardial perfusion defects. Multigated ventriculography showed an ejection fraction of 68% and 80% at rest and following exercise, respectively. Three separate fistulas were present between each coronary artery and the pulmonary trunk. The Qp:Qs ratio was 1.3. In the presence of atypical chest pain, stress MIBI scintigraphy and multigated ventriculography both failed to reveal myocardial ischemia in a 49-year-old patient with multiple coronary-pulmonary fistulas. She is using no medication, but advice concerning endocarditis prophylaxis was given.

Arterio-Arterial Fistula↗
PubMed1992

Failure of subclavian venepuncture: the internal jugular vein as a useful alternative.

After several attempts, temporary and permanent pacing for post-infarction symptomatic tachybradyarrhythmias, was finally achieved via the left internal jugular vein. Failure of bilateral subclavian venepuncture was experienced by two different operators. Partial right-sided pneumothorax developed following several attempts of subclavian puncture, and it resolved spontaneously. Upper extremity contrast venography revealed signs compatible with antecedent thrombotic disease of unknown etiology. Antiarrhythmic drug therapy was safely and successfully instituted.

Aged↗