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Biomedical subjects

S A Said

Publications and source records attributed to S A Said.

At least 37 records · Page 2Linked to original sources
PubMed1991

Coronary-cameral fistula in association with intracardiac tumour and aortic stenosis in an adult.

We present a patient with the unexpected association of left ventricular tumor, a fistula between the right coronary and the right atrium, and senile valvar aortic stenosis. He had anginal complaints. Doppler echocardiography revealed moderate aortic stenosis with mild aortic and moderate mitral regurgitation. A tumour was detected in the left ventricle. Selective coronary angiography disclosed normal anatomy with a fistula originating from the proximal right coronary artery and draining into the right atrium. He refused operative treatment and is still alive, 1 year after the diagnosis was made, without complications.

Aged↗
PubMed1991

Dextrocardia, situs inversus and severe mitral stenosis in a pregnant woman: successful closed commissurotomy.

A 16-weeks' pregnant woman with situs inversus and dextrocardia underwent successful closed commissurotomy for severe mitral stenosis. The electrocardiogram revealed sinus rhythm with right axis deviation and progressive diminishing of QRS amplitude towards the left precordial leads. The chest X-ray showed dextrocardia with situs inversus. Doppler echocardiography depicted severe mitral stenosis; the mitral valve area increased from 0.9 cm2 pre-operatively to 1.8 cm2 post-operatively with mild increase of mitral regurgitation from grade I to II post-valvotomy. She also had associated mild functional tricuspid insufficiency and moderate pulmonary hypertension. No thrombo-embolic complications occurred intra- or post-operatively. There was no evidence of either clinical or Doppler restenosis. The course of pregnancy was uneventful. At 39 weeks a healthy baby was vaginally delivered. The patient is still free of cardiac symptoms.

Adult↗
PubMed1990

Coronary-pulmonary fistula: long-term follow-up in operated and non-operated patients.

Eleven cases with 13, incidentally found coronary-pulmonary fistulous communications were discovered out of about 11,000 diagnostic coronary angiograms performed in different patients, over the period 1968 to 1989. These patients were followed-up for an average period of 4.4 years (range 2-11 years). The majority had a fistulous malformation originating from the proximal part of the left anterior descending artery and terminating in the pulmonary trunk. In three subjects, the right coronary artery participated in formation of the shunt. The fistulas consisted either of a convoluted mass of serpentive vessels, sometimes with aneurysmal formation, or of a solitary single vessel. Angina pectoris, atypical chest pain and fatigue were the most common symptoms. All patients were treated conservatively except one, who underwent ligation of the fistula and coronary arterial bypass grafting. Two subjects are still free of symptoms. No death occurred. None of the patients developed subacute bacterial endocarditis, acute myocardial infarction or left ventricular failure during the period of follow-up of more than four years. Three individuals, prior to the follow-up period, had suffered myocardial infarction contralateral to the shunt. They had no recurrence.

Adolescent↗
PubMed1989

Clinical evaluation of two monthly injectable contraceptives and their effects on some metabolic parameters.

One-hundred-and-thirty normally menstruating females were subgrouped equally and enrolled from the family planning clinic to study the clinical performance of the monthly injectable contraceptives medroxyprogesterone acetate 25 mg + estradiol cypionate 5 mg (Cycloprovera) and norethisterone enanthate 50 mg + estradiol valerate 5 mg (HRP-102) and their effects on some metabolic parameters. The contraceptive efficacy after 6 months of use for both drugs was 100%. No change in menstrual pattern occurred in 74% of Cycloprovera users and 67.3% of HRP-102 users. A statistically significant decrease (P less than 0.01) occurred in HDL-cholesterol and total serum protein values and a statistically significant increase (P less than 0.01) was observed in hematocrit value of Cycloprovera users only. Body weight and blood pressure values after 6 months of drug use showed no statistically significant changes in both groups. Also, no statistically significant changes were noticed in both groups for hemoglobin, post-prandial blood glucose, cholesterol, A/G ratio, SGPT and SGPT values following 6 months of injectable contraceptive use. None of the injectable users developed cervical dysplastic changes cytologically.

Alanine Transaminase↗
PubMed1989

Some metabolic and hormonal changes in women using long acting injectable contraceptives.

Some metabolic and hormonal changes in women using longacting injectables as a contraceptive method were examined. The 2 main injectables utilized were depomedroxyprogesterone acetate (DMPA), given every 90 +or- 5 days, and norethisterone enanthate (NET/EN) injected every 60 +or- 5 days. None of the studied cases became pregnant during injectable use, indicating the high contraceptive efficacy of the method. No statistically significant changes were observed in hemoglobin, hematocrit, all protein fractions including albumin, alpha1, alpha2 beta, gamma immunoglobulins IgG, IgA, and IgM after 6 and 12 months in both groups of injectable users as compared with the preinjection values. Statistically significant suppression of the estimated hormones, Follitropin, Luteotropin, and Estradiol-17beta were detected in both groups of NET/EN and DMPA users, after 6 and 12 months, as compared with the preinjection values.

Africa↗
PubMed1989

Influence of cimetidine on the pharmacokinetics of piroxicam in rat and man.

The influence of cimetidine on piroxicam plasma levels and pharmacokinetic parameters was studied in both rats and healthy volunteers. In male rats, intravenous injection of piroxicam (6 mg/kg) in animals pretreated with cimetidine (50 mg/kg intramuscular) resulted in plasma piroxicam concentrations significantly higher than those of animals which received piroxicam alone. The plasma half-life (1/2) of piroxicam in male rats was about 8.3 h and it was increased to 20.74 h by cimetidine pretreatment. The mean area under piroxicam plasma level-time curves was significantly (p less than 0.01) higher in case of rats pretreated with cimetidine compared with those treated with piroxicam alone. Similar results were obtained in male healthy volunteers, where administration of a single dose of piroxicam (20 mg orally) to subjects who received cimetidine (200 mg 3 times a day orally) resulted in plasma piroxicam concentrations significantly higher than those of subjects treated with piroxicam alone. The t1/2 of piroxicam was increased from 37.36 to 52.86 h with cimetidine administration. Also the mean area under piroxicam plasma level-time curves was significantly (p less than 0.05) increased by cimetidine administration.

Administration, Oral↗
PubMed1982

GLC determination of methoxsalen in human serum and urine.

A simple, sensitive and specific GLC method for the quantitation of methoxsalen in human serum and urine is described. The procedure involves chloroformic extraction of the active ingredient and the internal standard, trioxsalen, followed by GLC determination, using flame ionization detector and 3% OV on a Gas chromosorb W column. Sensitivity was 0.1 microgram/ml and 0.2 microgram/ml for serum and urine, respectively. Methoxsalen contents of serum of rats treated with this drug are reported.

Animals↗
PubMed1981

Hypoglycemic activity of oral hypoglycemics with increased hydrophilicity.

The effect of increasing the hydrophilicity of acetohexamide and tolbutamide with hydroxypropyl methylcellulose and methylcellulose on drug dissolution and hypoglycemic activity in rats was examined. The dissolution rate of both drugs was increased according to the type and concentration of the polymer. The oral absorption of both drugs was improved, as indicated by potentiation of the reduction in blood glucose in rats. The efficiency of the polymer in increasing the dissolution rates of of the drugs correlated with hydrophilicity of the polymer.

Administration, Oral↗
PubMed1981

Effect of antacids on activity of oral hypoglycemics.

The effect of some antacids on the dissolution and hypoglycemic activity of acetohexamide, tolazamide, and tolbutamide tablets was investigated, as was the adsorption of the three drugs onto the antacids. The dissolution rates of the three drugs in the presence of magnesium oxide, aluminum hydroxide, magnesium carbonate, and calcium carbonate increased (0.5-1 hr) and then plateaued or decreased (1-3 hr). Magnesium trisilicate directly suppressed the dissolution of the three drugs. The antacids reduced the hypoglycemic activity of tolbutamide in the following order:magnesium trisilicate greater than magnesium oxide greater than aluminum hydroxide greater than magnesium carbonate greater than calcium carbonate. The same order occurred for the first three antacids with acetohexamide and tolazamide. Decreased hypoglycemic activity of the drugs may have been due to their adsorption to the coadministered antacids.

Adsorption↗
PubMed1981

Release and organ distribution of 125I from povidone-iodine under the influence of certain additives.

The effect of certain additives on the release and oral absorption of 125I from povidone-125I was studied. Ethanol and benzalkonium chloride were found to increase the release of 125I from its povidone complex, more than any one of the other additives. Both agents increased the absorption of 125I, 24 h after oral administration to rats, from 2.4 to 9.8%, respectively. The possible influence of application of povidone-iodine on certain clinical tests is discussed.

Animals↗
PubMed1981

Influence of biological fluids on the release of 125I from povidone-iodine.

A study on the influence of vaginal smear, blood cells and human plasma on the release of 125I from povidone-iodine was conducted. The total amounts of iodine released from povidone-iodine in presence of saliva and vaginal smear are 9.51% and 5.99%, respectively, as compared to 5.9 in normal saline solution. Blood cells and plasma were found to take up 54.2 and 80.1% of iodine released from povidone-iodine. The possible effect of these fluids on the antimicrobial activity of povidone-iodine is discussed.

Blood Cells↗
PubMed1981

Pharmacokinetics of diclofenac sodium using a developed HPLC method.

The pharmacokinetics of 2-[(2,6-dichlorophenyl)-amino]phenyl acetic acid (diclofenac sodium) was studied after a single oral dose of 10 mg/kg in rabbits, using a developed HPLC method. The observed serum levels of rabbits were fitted to a one-compartment open model, with first-order absorption and elimination. The mean values of t1/2e, ke, 51/2a, ka and tmax were 1.98 h, 0.3455 h-1, 1.2357 h, 1.2357 h, 0.5653 h-1 and 2.2267 h, respectively. This high-performance liquid chromatographic method for the rapid (about 10 min), sensitive (1 microgram/ml) and specific determination of diclofenac sodium in serum and urine was developed using acetaminophen as the internal standard, a reversed-phase C 18 column, and ethanol: water (1:2) as the mobile phase.

Acetaminophen↗
PubMed1980

Influence of various agents on adsorption capacity of kaolin for Pseudomonas aeruginosa toxin.

The in vitro adsorption of 125I-labeled Pseudomonas aeruginosa toxin (I) onto kaolin (II) at various pH values and in the presence of various agents was studied. The maximal adsorption capacity of I onto II occurred at pH values below 4.1, while minimal values were observed at pH 4.1, 7.4, and 8; average adsorption occurred at pH 5 and 6. The tested agents at specific ratios to II decreased the percent adsorption capacity of II for I to various degrees. The results are explained by reference to the structures of both kaolin and the toxin.

Adsorption↗
PubMed1980

Khellin determination in human serum and urine by high-performance liquid chromatography.

A rapid, sensitive, and specific high-performance liquid chromatographic method was developed for the determination of khellin in serum and urine using theophylline as the internal standard. Chromatography was performed on a reversed-phase C18 column with 65% (v/v) methanol as the mobile phase. The assay is capable of measuring khellin concentrations down to 100 ng/ml with a total procedure time of less than 20 min. Oral administration of 60 mg of khellin tablets to two healthy human males was carried out, and the serum samples were analyzed by the described method. Serum concentration-time profiles are presented.

Chromatography, High Pressure Liquid↗