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Biomedical subjects

S A Tikhodeev

Publications and source records attributed to S A Tikhodeev.

At least 19 recordsLinked to original sources
PubMed1996

[Immunological studies and the problems of the pathogenesis of osteoarticular tuberculosis (tuberculous spondylitis, tuberculous synovitis)].

Tests of levels 1-2 were employed to study immune status of 102 patients with tuberculous lesions of the spine and knee joint. Investigations of humoral local response in these patients provided evidence for comparison with systemic response, advanced diagnosis of tuberculous spondylitis and synovitis. It was found that high level of antituberculous antibodies in the synovial fluid is typical for specific allergic synovitis where synovial membrane represents the organ of immunogenesis. The appearance of even minimal number of antituberculous antibodies in the liquor indicates disorder of immune and hematoencephalic barriers of the brain in tuberculous spondylitis complicated with spinal meningitis.

Adult↗
PubMed1993

[Indicators of systemic and local immunity in patients with spinal tuberculosis].

The examination of 33 patients with tuberculous spondylitis and its sequelae revealed inhibition of T-cell immunity in 40% of the examinees, antituberculous antibodies in the blood of 73% of patients. An enzyme immunoassay detected antituberculous antibodies in cerebrospinal fluid of 70% seropositive sufferers with spinal tuberculosis. Positive results of this test serve a direct indication to spinal decompression and intensive pre- and postoperative antituberculosis treatment.

Adult↗
PubMed1993

[Pathologic changes in vertebral osteomyelitis].

Osteomyelitis of the vertebral column (VC) was considered in the past as a form of sepsis. The disease developed after purulent infection provoked by staphylococcus, enterobacteria and other infectious agents, rapidly progressed and terminated not infrequently, by a patient death. Wide spread destructive process due to the purulent lysis of the bone and cartilage was observed in VC. This disease acquired some new features at present. Although its etiology remained the same, osteomyelitis of VC is now chronic inflammatory process with recurrences and formation of purulent foci in VC with the spread to the paravertebral tissues and adjacent organs. The number of grave complications is reduced and lethal cases are practically absent.

Acute Disease↗
PubMed1991

[Osteoplasty in limited forms of tubercular spondylitis].

The developed variants of free and non-free vertebral autoplasty are considered to be optimal in the surgical management of tuberculous spondylitis. Their application is associated with the damage to vertebral bodies, the degree of their destruction, the extent of intervertebral diastasis, and the process site. Proper repair of the vertebral defects, not exceeding 5 cm, is achieved by free autografts having the maximum area of supporting ends. With extensive intervertebral diastasis, it is recommended to use non-free grafts taken from a rib or the upper flaring portion of the ilium and to overlap the plasty area with the rib periosteum on a feeding pedicle. In terms of significance order, the prognostic criteria for plasty outcomes are congruence of the graft ends with the grooves formed in the vertebral bodies; the extension of a suppurative process in the adjoining transplant tissues, adequate correction of intervertebral diastasis; and the length of transplants.

Adult↗
PubMed1991

[Tactics in surgical treatment of combined and complicated forms of active tuberculosis of the spine and lung].

Questions related to surgical treatment of combined forms of active spinal and pulmonary tuberculosis are discussed. The results of conservative and surgical treatment of 14 patients with this pathology were analysed. Tactics of treatment of such patients was established. It was shown that emergency surgery on the spine because of the developing complications can be performed together with intensive antituberculous therapy.

Adolescent↗
PubMed1990

[Surgical treatment of hematogenic osteomyelitis of the spine].

The article presents principles of the surgical treatment of hematogenic osteomyelitis of the vertebral column and its complications developed on the basis of studying and analysis of results of operative interventions performed in 145 patients. A system of operative procedures is proposed which showed high effectiveness in treatment of both purulent infections and complications of the disease, spinal disorders in particular.

Bone Transplantation↗
PubMed1986

[Indicators of intraosseous pressure and venospondylography in the diagnosis of inflammatory diseases of the spine].

The measuring of the intraosseous pressure and venospondilography were included into the complex of examination of 82 patients in order to increase the efficiency of diagnostics and differentiation of osteomyelitis and tuberculosis of the vertebral column. The methods used considerably increased the reliability of diagnosis of these inflammatory diseases of the vertebral column.

Adolescent↗