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Biomedical subjects

S Abo

Publications and source records attributed to S Abo.

At least 55 records · Page 3Linked to original sources
PubMed1992

[A case of congenital esophago-bronchial fistula communicated between esophageal diverticulum and left main bronchus in the adult--a review of 47 cases in the Japanese literature].

We experienced a successful repair of congenital esophago-bronchial fistula communicated between esophageal diverticulum and left main bronchus in adult case. The patient was a 60-year-old female. She had much wet cough on taking meals since 10 years ago. At the mass screening, a esophago-bronchial fistula was detected by upper GI series. Barium esophagography revealed a fistula between esophageal diverticulum and left main bronchus. The resection of diverticulum and fistula were undergone. In the operation, there exited no adhesion or inflammation around the fistula, therefore it was easy to isorate from the surrounding tissues. This case was categorized as Brainbridge type I esophago-bronchial fistula communicated to left main bronchus. Forty-six cases of congenital esophago-bronchial fistula with diverticulum were reported in Japan, but no cases which communicated with left main bronchus were reported. Then it is assumed that this is the first case in Japan.

Bronchial Fistula↗
PubMed1991

[Analysis of prognostic factors in patients with carcinoma of the thoracic esophagus].

Prognostic factors in patients with carcinoma of the thoracic esophagus were analysed. From May 1972 to February 1989, 361 cases were resected in our department. Cases of histological curability 0, double cancer, death within 30 days after operation, death due to other diseases and cancer except squamous cell carcinoma were excluded, and 170 were chosen for this study. We classified these cases into two groups according to the survival period; Group 1: cases died within 2 years after operation, Group 2: cases lived more than 2 years. Factors analyzed were as follows; sex, age, location of the lesion, radiological classification, radiological vertical extension, axial deviation of the esophagus, endoscopic classification, endoscopic horizontal location, resectability, longitudinal diameter, histologic differentiation, depth of invasion, degree of lymphnode metastasis, range of lymphnode metastasis, lymphatic invasion, blood vessel invasion, intraepitherial spread, intramural metatasis, histologic stage and histologic curability. Factors related to prognosis were age, radiologic classification, depth of invasion, degree of lymphnode metastasis, histologic stage and histologic curability. In the next step, these cases were also classified into three groups according to the degree of lymphnode metastasis (n(-), n1 + 2(+), n3 + 4(+) and factors which influenced prognosis were analysed in each group. In the group without lymphnode metastasis, there was a statistical difference in survival rate between cases with intramural metastasis and cases without that. In groups with lymphnode metastasis (n1 + 2(+), n3 + 4(+), any factors such as the degree and range of metastasis or intramural metastasis had no influence on prognosis. So it was concluded that lymphnode metastasis itself was an important factor for prognosis.

Age Factors↗
PubMed1988

[Cooperative research on post-operative adjuvant therapy of breast cancer. Tohoku Society of Adjuvant Chemo-endocrine Therapy of Breast Cancer].

A randomized trial was carried out in 55 institutes in the Tohoku district to examine the significance of breast cancer post-operative adjuvant chemo-endocrine therapy in stage II and IIIa patients for possible radical mastectomy. A total of 619 patients were entered from November 1982 to November 1984, of whom 554 were eligible. Patients were administered MMC 13 mg/m2 after surgery, and randomized using the envelope method into either group A, treated with Tegafur 400 mg/m2 alone (275 patients), or group B, treated with Tegafur 400 mg/m2 and Tamoxifen 20 mg/daily (279 patients), for a year from the 7th day after operation. There was no significant difference between the two groups in the background factors of age, menopausal status, operation methods, stage or number of positive lymph nodes, but there were more patients of ER(+) in group B. A Kaplan-Meier method comparison showed no significant difference between the two groups in 3-year disease-free survival rates. There was no significant difference between the two groups compared by ER or menopausal status. However, patients with 4 or more positive lymph nodes showed a significant benefit in group B. Group B also marked a higher disease-free survival rate for ER(+) patients with 4 or more positive lymph nodes.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

[Experience with transvenous retrieval of a fractured IVH catheter from the superior caval vein--a study of the mechanism of catheter breakage by a model tension test].

An IVH catheter which was left in the superior caval vein was removed using a myocardial bioptome. It was accidentally broken when the patient unintentionally pulled it out. The cut surface was examined and it was confirmed that the IVH catheter could be broken irrespective of any defect of the catheter itself. To clarify the mechanism of catheter breakage, a model tension test was performed. The tensile strength and elongation were examined in 3 ways; first without binding, second with binding, third with binding and also pulling backward. The rate of tension was also varied from 100mm/min to 1,000 mm/min. It was found that the catheter was easier to break when pulled out faster, with binding, and pulled backward. When pulled forward, it was elongated and the site of breakage was not at the site of binding. However, when pulled backward, it was less elongated and the site of breakage was at the site of binding. An electron microscopic examination of the removed catheter revealed that the cut surface resembled that being pulled backward at a rate of 1,000 mm/min. The above suggests that, in this case, the IVH catheter was trapped between the clavicle and the 1st rib and pulled at an angle.

Aged↗
PubMed1986

[Continuous measurement of tumor blood flow under hypertension induced by angiotensin II--clinical studies with laser Doppler velocimetry].

The effect of treatment with intravenously administered Angiotensin II (AT II) on blood flow in normal and malignant tissues was investigated clinically. The time course of the effect of AT II was directly recorded by laser doppler velocimetry (LDV) via a probe placed on the surface of normal and malignant tissues. Intravenous administration of AT II resulted in an approximate 3.5 (1.3-14.0)-fold increase in blood flow in eleven malignant tissues, such as breast cancer with direct extension to the skin and abdominal skin metastasis of gastric adenocarcinoma. On the other hand, the blood flow in normal skin was decreased under AT II-induced hypertension, but a reactive hyperemia-like increase was observed soon after the withdrawal of AT II. These results strongly suggested that intravenously administered AT II can act as an adjuvant to enhance, by varying degrees, drug delivery to tumor tissue in cancer chemotherapy and that the administration of chemotherapeutic agents is undesirable soon after the withdrawal of AT II.

Adenocarcinoma↗
PubMed1986

[Phase II study of cisplatin in esophageal carcinoma].

A multi-institutional cooperative phase II study of Cisplatin for esophageal carcinoma was conducted. Cisplatin was administered by i.v. infusion at 10-20 mg/m2 body surface area daily for 5 days and repeated every 3-4 weeks (method A) or at 50-100 mg/m2 body surface area once every 3-4 weeks (method B). Out of 78 cases entered, 47 were evaluable. No complete response (CR) was obtained and partial responses (PR) were observed in 10 cases, the overall response rate being 21.3%. Response rates by administration methods A and B were 12.5% and 25.8%, respectively. Responders to treatment exhibited significantly longer survival periods compared to non-responders (p less than 0.05, generalized Wilcoxon test). Major adverse reactions were gastrointestinal symptoms, generalized malaise, bone marrow suppression and renal disorders. One case of leukopenia leading to eventual death from pneumonia was observed.

Adult↗
PubMed1985

[Enhancing activity of bacterial preparations on blood flow in tumor tissue, with reference to cancer chemotherapy. Experimental and clinical studies].

The effect of treatment with bacterial preparations on blood flow in normal and malignant tissues was investigated, clinically and experimentally. The time course of the local effect of the preparations was recorded by Laser Doppler Velocimetry (LDV) via a probe on the surface of normal and malignant tissues directly over the injection site. Experimentally, no definite enhancement of blood flow with OK-432, a streptococcal preparation, was observed in nude mice. Clinically, intradermal administration of OK-432 or tuberculin (PPD) resulted in an approximate 11-or 4-fold increase in blood flow, respectively. The injection of OK-432 into malignant tissues, such as dermal cancer and breast cancer with direct extension to the skin, resulted in an approximate 3.5-fold increase. The results suggested that bacterial preparations can act as an adjuvant to enhance drug delivery to tumor tissue in cancer chemotherapy, and that the enhancement of blood supply is induced by immune response.

Adult↗
PubMed1984

[Advantages and limits on the surgical therapy of esophageal cancer].

During a 11-year period, 315 patients of squamous cell carcinoma of the thoracic esophagus were treated. Notwithstanding the great majority of the patients had advanced cancer and operative contra-indications were very limited, the percentage of the operation of total patients was 94% (297/315) and that of operative mortality was 7.0% (20/297). As a standard surgical procedure, subtotal esophagectomies were performed through a right thoracotomy, followed by a laparotomy with simultaneous reconstruction via the posterior mediastinal route. On the 181 cases of the squamous cell carcinoma of the thoracic esophagus resected and reconstructed by this method before 1977, the survival rate of 1-year was 50%, that of 3-years was 19% and that of 5-years was 10%. Post operative T-shaped irradiation was performed in about a half of the total 181 patients. The efficacy of the postoperative irradiation was discernible in patients of each stage. It is expected that a precise schedule of chemotherapy and immunotherapy combined with post-operative irradiation might improve the prognosis of the esophageal cancer.

Adult↗
PubMed1982

[Phase II study on peplomycin for esophageal cancer].

For the purpose of verifying the effectiveness of peplomycin, one of the derivatives of bleomycin, against carcinoma of the esophagus and the safety of it, the analysis of the data for total 113 cases collected from 25 institutions in Japan was made. The results are as follows. It was effective in 19 out of 74 evaluable cases of carcinoma of the esophagus (25.7%). In case of treatment with peplomycin alone, it was effective in 6 out of 39 cases (15.4%). In case of the combination treatment with peplomycin and some other therapy, it was effective in 13 out of 35 cases (37.1%). As for the side effects, the incidence of fever was the highest in both the cases of peplomycin alone and the combination treatment such as 39.6% and 37.0%, respectively. Anorexia, nausea, vomiting, respiratory symptoms and tiredness were found in relatively many cases. In the clinical laboratory tests, the vital capacity after the treatment tended to be lower than that before the treatment, but there was little change in the hematological tests, pulmonary function test and renal function test.

Adult↗