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Biomedical subjects

S Azuma

Publications and source records attributed to S Azuma.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Successful treatment of advanced gastric cancer by combined cisplatinum, mitomycin C and 5-FU administration. A case report].

A 55-year-old woman with gastric cancer underwent laparotomy and was found to have an unresectable tumor at the MC region, characterized by S3 (invasion into the pancreas), N3, P0, H0, Borrmann-II and moderately differentiated tubular adenocarcinoma. She was then treated by combined administration of cis-dichlorodiammine platinum (CDDP), mitomycin C and 5-fluorouracil (5-FU). A complete response was confirmed by upper gastrointestinal roentgenography and endoscopy. Upon reoperation 4 months after the initial laparotomy, a successful total radical gastrectomy with R2 (partially R3) lymph node dissection was performed. Histological examination of the specimens, including the stomach and lymph nodes, revealed no cancer cells in any region.

Adenocarcinoma↗
PubMed1987

[Experience with CDDP therapy in advanced and recurrent gastric cancer cases].

For 3 years beginning in 1984, 14 advanced and recurrent gastric cancer cases with measurable lesions (8 unresected cases, 3 cases of recurrence, 2 cases with non-curative resection, 1 case of no operation) were treated by CDDP therapy alone or in combination with other chemotherapies. CR was obtained in 2 of the 8 non-resected cases, radical gastrectomy being feasible in these 2 cases by second-look operation. Five of the 8 cases showed PD, and in 1 case the effect was rather obscure. One of the 2 non-curative resection cases achieved PR, and the other case was MR. One of the 3 recurrent cases was NC, the remaining cases being PD. The one case given no operation showed PD. Overall effectiveness of CDDP therapy for advanced and recurrent gastric cancer cases was seen in 3 (21.4%) of the 14 cases. All of these 3 cases showing effective CDDP therapy was elevated serum CEA values before the therapy, which was markedly reduced after starting the therapy, the reduction rate being very remarkable.

Adult↗
PubMed1984

On the pathway of the rectosphincteric reflex.

In several rat models, including those with circular and semicircular rectal aganglionosis, the rectosphincteric reflex was examined. The reflex was confirmed to be essentially an intramural one and its route is considered to run mainly in the longitudinal and partly in the oblique directions.

Anal Canal↗
PubMed1984

Studies on gustatory responses of amygdaloid neurons in rats.

The responses of 80 amygdaloid neurons to the four basic taste (sucrose, NaCl, HCl and quinine hydrochloride), thermal (5 degrees C, 20 degrees C and 40 degrees C) and tactile (brushing) stimuli applied to the anterior part of the tongue were recorded in anesthetized rats. About 90% of the taste-sensitive amygdaloid neurons responded to thermal and/or tactile stimulations of the tongue as well, and some of them showed convergent responses to tactile stimulation of various parts of the body and to acoustic stimulation. Most (86%) amygdaloid taste-sensitive neurons showed a phasic pattern of excitatory response lasting 1-2 s after onset of stimulation with the broad breadth of tuning to the four taste stimuli. About 35% of the neurons showed monotonic increasing responses with increasing NaCl concentration. The rest of the neurons showed complex intensity-response function. The amygdaloid neurons could be grouped into classes based on their best responsive stimulus, and the response profiles of those neurons showed relative regularity when the four stimuli were hedonically ordered from most to least preferred (i.e., sucrose, NaCl, HCl, quinine). Across-neuron correlations between magnitudes of responses to pairs of the four basic taste stimuli have suggested a tendency that taste information is processed in a hedonic dimension in the amygdala. The neurons in the central (Ce) nucleus showed some differential taste responses from those in other amygdaloid nuclei, i.e., about half of the Ce neurons showed tonic responses, and the across-neuron correlation coefficients in the Ce neurons were much higher than those in the non-Ce neurons.

Amygdala↗
PubMed1984

Functional relations between the cortical gustatory area and the amygdala: electrophysiological and behavioral studies in rats.

The functional interconnections between the cortical gustatory area (CGA) and the amygdala were examined by electrophysiological and behavioral experiments in rats. The cortical neurons responsive to taste stimuli applied to the anterior part of the tongue were located in the Vth layer of the agranular insular cortex. Of a total of 27 cortical neurons recorded, 10 showed facilitatory and/or inhibitory responses with the mean onset latency of about 20 msec to electrical stimulation of the ipsilateral amygdala. On the other hand, of 18 amygdaloid neurons responsive to taste stimuli, 13 showed facilitatory and/or inhibitory responses to electrical shocks to the ipsilateral CGA, with a mean latency of about 16 ms. No cortical and amygdaloid neurons sampled responded antidromically to the electrical stimulation. These results suggest the existence of mutual polysynaptic fiber connections between the CGA and the amygdala. The behavioral experiment was performed by means of a conditioned taste aversion (CTA) technique. After acquisition of CTA to sucrose solution by pairing it with an i.p. injection of LiCl which produces sickness, bilateral small knife cuts between the CGA and the amygdala in the perirhinal region disrupted retention of CTA. Thus, these interconnections may play some role in association of taste-related cognitive processes with feeding behavior.

Amygdala↗
PubMed1984

Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the OA-6129 group of carbapenem compounds as the direct precursors for PS-5, epithienamycins A and C and MM 17880.

Based on the working hypothesis that the OA-6129 group of carbapenem compounds might be the direct precursors for PS-5, epithienamycins A and C and MM 17880, Streptomyces fulvoviridis A933 17M9, a producer of PS-5, PS-6, PS-7, PS-8, epithienamycins A, B, C and D, MM 17880, MM 13902 and MM 4550, was subjected to NTG-mutation to provide a blocked mutant numbered 1501 which was found to produce OA-6129 A, OA-6129B1, OA-6129B2 and OA-6129C instead of PS-5, epithienamycins A and C and MM 17880, respectively. In a cell-free system, the parent strain demonstrated an ability to convert OA-6129A to NS-5, whereas the mutant did not. The L- and D-amino acid acylases were also shown to depantothenylate the OA-6129 group of carbapenems.

Amidohydrolases↗
PubMed1982

Gustatory reaction time under variable stimulus parameters in human adults.

Reaction times and perceived intensities for NaCl solutions were measured in sixteen human adults. Stimulus delivery was by means of a circular piece of solution-soaked filter paper held with forceps. The reaction time (T) decreased and the perceived intensity (S) increased with increasing the concentration (C) of NaCl solution applied to a fixed (78.5 mm2) tongue area. The comprehensive relations among T, S and C can be expressed by the following formula; T=a+b/log(C/Co), T=p+q/log(S/So), and logS=mlogC+logn, where a, b, p, q, m, n=constants, and So indicates the perceived intensity at the threshold concentration (Co). Meanwhile, the reaction time decreased and the perceived intensity increased with increasing the stimulated area (A) under a fixed (1.0 M) concentration of NaCl solution. The relations among T, S and A can also be expressed by the following equations; T=a'+b'/log(A/Ao), T=p'+q'/log(S/So), and logS=m'logA+logn', where a', b', p', q', m', n'=constants, and Ao indicates the threshold size of stimulated area.

Adult↗