Biomedical subjects

S Bentin

Publications and source records attributed to S Bentin.

At least 19 recordsLinked to original sources

PubMed2000

Neurophysiological correlates of face gender processing in humans.

Event-related potentials (ERPs) were recorded while subjects were involved in three gender-processing tasks based on human faces and on human hands. In one condition all stimuli were only of one gender, preventing any gender discrimination. In a second condition, faces (or hands) of men and women were intermixed but the gender was irrelevant for the subject's task; hence gender discrimination was assumed to be incidental. In the third condition, the task required explicit gender discrimination; gender processing was therefore assumed to be intentional. Gender processing had no effect on the occipito-temporal negative potential at approximately 170 ms after stimulation (N170 component of the ERP), suggesting that the neural mechanisms involved in the structural encoding of faces are different from those involved in the extraction of gender-related facial features. In contrast, incidental and intentional processing of face (but not hand) gender affected the ERPs between 145 and 185 ms from stimulus onset at more anterior scalp locations. This effect was interpreted as evidence for the direct visual processing of faces as described in Bruce and Young's model [Bruce, V. & Young, A. (1986) Br. J. Psychol., 77, 305-327]. Additional gender discrimination effects were observed for both faces and hands at mid-parietal sites around 45-85 ms latency, in the incidental task only. This difference was tentatively assumed to reflect an early mechanism of coarse visual categorization. Finally, intentional (but not incidental) gender processing affected the ERPs during a later epoch starting from approximately 200 ms and ending at approximately 250 ms for faces, and approximately 350 ms for hands. This later effect might be related to attention-based gender categorization or to a more general categorization activity.

Adult↗

PubMed2000

Electrophysiological evidence for an early(pre-attentive) information processing deficit in patients with right hemisphere damage and unilateral neglect.

Patients with right hemisphere damage and contralesional neglect are often unaware of visual, auditory or tactile stimuli occurring on their left side. In an effort to understand the contribution of pre-attentive processes to this phenomenon, we examined the processing of the pitch, duration and spatial location of auditory stimuli using an electrophysiological probe, the mismatch negativity (MMN). This event-related brain potential indexes the integrity of cerebral processes that respond automatically to deviations from regularity in the acoustic environment. We compared the MMN elicited by right- and left-sided deviant stimuli in 10 patients with left unilateral neglect and 10 age-matched healthy volunteers, exploring an anticipated dissociation between the processing of spatial localization of sounds and the processing of the other auditory dimensions. Across dimensions, the MMN elicited by deviance occurring to the left of the patients was reduced relative to that elicited by deviance occurring to the right. This effect was robust for spatial location, and less so for pitch, whereas the processing of stimulus duration was not significantly affected by the side of stimulation. In healthy subjects, deviance in either side elicited similar MMN. We suggest that an early deficit in detecting changes in the environment hampers the involuntary triggering of attention in those patients and discuss the specific role of encoding spatial location in the establishment of conscious awareness.

Adult↗

PubMed1999

Selective visual streaming in face recognition: evidence from developmental prosopagnosia.

Computational considerations suggest that efficient face identification requires the categorization and exclusive streaming of previously encoded face visual primitives into a dedicated face recognition system. Unique evidence supporting this claim is provided by a rare case of developmental pure prosopagnosia with otherwise normal visual and cognitive functions. Despite his normal visual memory and ability to describe faces, he is extremely impaired in face recognition. An early event related brain potential (N170) that is normally elicited exclusively by human faces, showed no specificity in this person. MRI revealed a smaller then normal right temporal lobe. These data emphasize the indispensability of the early streaming process for face recognition.

Adult↗

PubMed1999

Semantic influence on processing gender agreement: evidence from Hebrew.

In the present study we examined the influence of manipulating the animacy of the sentential subject on the size of the syntactic priming effect induced by violation of subject-predicate gender agreement in Hebrew. The agreement violation delayed naming incongruent compared with congruent predicates. This priming effect was stronger when the sentential subject was an animate than an inanimate noun. Additional experiments revealed that: (1) the interaction between the priming effect and animacy of the subject could not be explained on the basis of differences in the phonological transparency of the gender inflection in the two groups of nouns, and (2) it was sensitive to the ratio of animate/inanimate conditions in a block. We suggest that the interaction between the processing of agreement and the effect of animacy is influenced by a controlled process of verifying the coherence of a currently identified word within a built-up context.

Adult↗

PubMed1999

ERP manifestations of processing printed words at different psycholinguistic levels: time course and scalp distribution.

The aim of the present study was to examine the time course and scalp distribution of electrophysiological manifestations of the visual word recognition mechanism. Event-related potentials (ERPs) elicited by visually presented lists of words were recorded while subjects were involved in a series of oddball tasks. The distinction between the designated target and nontarget stimuli was manipulated to induce a different level of processing in each session (visual, phonological/phonetic, phonological/lexical, and semantic). The ERPs of main interest in this study were those elicited by nontarget stimuli. In the visual task the targets were twice as big as the nontargets. Words, pseudowords, strings of consonants, strings of alphanumeric symbols, and strings of forms elicited a sharp negative peak at 170 msec (N170); their distribution was limited to the occipito-temporal sites. For the left hemisphere electrode sites, the N170 was larger for orthographic than for nonorthographic stimuli and vice versa for the right hemisphere. The ERPs elicited by all orthographic stimuli formed a clearly distinct cluster that was different from the ERPs elicited by nonorthographic stimuli. In the phonological/phonetic decision task the targets were words and pseudowords rhyming with the French word vitrail, whereas the nontargets were words, pseudowords, and strings of consonants that did not rhyme with vitrail. The most conspicuous potential was a negative peak at 320 msec, which was similarly elicited by pronounceable stimuli but not by nonpronounceable stimuli. The N320 was bilaterally distributed over the middle temporal lobe and was significantly larger over the left than over the right hemisphere. In the phonological/lexical processing task we compared the ERPs elicited by strings of consonants (among which words were selected), pseudowords (among which words were selected), and by words (among which pseudowords were selected). The most conspicuous potential in these tasks was a negative potential peaking at 350 msec (N350) elicited by phonologically legal but not by phonologically illegal stimuli. The distribution of the N350 was similar to that of the N320, but it was broader and including temporo-parietal areas that were not activated in the "rhyme" task. Finally, in the semantic task the targets were abstract words, and the nontargets were concrete words, pseudowords, and strings of consonants. The negative potential in this task peaked at 450 msec. Unlike the lexical decision, the negative peak in this task significantly distinguished not only between phonologically legal and illegal words but also between meaningful (words) and meaningless (pseudowords) phonologically legal structures. The distribution of the N450 included the areas activated in the lexical decision task but also areas in the fronto-central regions. The present data corroborated the functional neuroanatomy of word recognition systems suggested by other neuroimaging methods and described their timecourse, supporting a cascade-type process that involves different but interconnected neural modules, each responsible for a different level of processing word-related information.

Adult↗

PubMed1998

Temporal cortex activation in humans viewing eye and mouth movements.

We sought to determine whether regions of extrastriate visual cortex could be activated in subjects viewing eye and mouth movements that occurred within a stationary face. Eleven subjects participated in three to five functional magnetic resonance imaging sessions in which they viewed moving eyes, moving mouths, or movements of check patterns that occurred in the same spatial location as the eyes or mouth. In each task, the stimuli were superimposed on a radial background pattern that continually moved inward to control for the effect of movement per se. Activation evoked by the radial background was assessed in a separate control task. Moving eyes and mouths activated a bilateral region centered in the posterior superior temporal sulcus (STS). The moving check patterns did not appreciably activate the STS or surrounding regions. The activation by moving eyes and mouths was distinct from that elicited by the moving radial background, which primarily activated the posterior-temporal-occipital fossa and the lateral occipital sulcus-a region corresponding to area MT/V5. Area MT/V5 was also strongly activated by moving eyes and to a lesser extent by other moving stimuli. These results suggest that a superior temporal region centered in the STS is preferentially involved in the perception of gaze direction and mouth movements. This region of the STS may be functionally related to nearby superior temporal regions thought to be involved in lip-reading and in the perception of hand and body movement.

Adult↗

PubMed1998

Levels of processing and selective attention effects on encoding in memory.

The purpose of the present study was to investigate the effects of selective attention and levels of processing (LOPs) at study on long-term repetition priming vis-a-vis their effects on explicit recognition. In a series of three experiments we found parallel effects of LOP and attention on long-term repetition priming and recognition performance when the manipulation of these factors at encoding was blocked. When a mixed study condition was used, both factors affected explicit recognition, while their effect on repetition priming was determined by the nature of the test. Shallow processing at test did not benefit from long-term repetition, regardless of whether the words had been studied deeply or shallowly. Selective attention affected long-term repetition priming in a semantic, but not in a lexical decision (LD), test. Regardless of study condition, retention lag affected long-term repetition priming only in the semantic test. These results suggest that if the experimental conditions allow scrupulous selection of attended and unattended information or narrow tuning to a shallow, pre-lexical LOP, implicit access to unattended or shallowly studied items is significantly reduced, as is explicit recognition. We suggest a conceptual framework for understanding the effects of LOP, attention, and retention interval on performance of explicit and implicit tests of memory.

Analysis of Variance↗

PubMed1998

Mismatch negativity in dichotic listening: evidence for interhemispheric differences and multiple generators.

The characteristics of mismatch negativity (MMN) elicited by dichotic stimulation were examined using frequency-deviant stimuli presented to the right, to the left, or to both sides. The experiment was run twice, once using earphones and once using loudspeakers in free field. With both modes of stimulation, deviants presented in the left, right, or both ears, or tones that were switched between ears, elicited comparable MMNs, with a peak latency of about 180 ms. With earphones, the amplitude of the MMN was bigger at the frontal-lateral right hemisphere sites than at the homologous left-hemisphere sites for all deviance conditions. Scalp current density analysis revealed that deviance in the right side elicited bilaterally equivalent frontal current sinks and a trend towards stronger contralateral current sources at the mastoid sites. In contrast, left side deviance elicited frontal sinks and temporal current sources stronger over the right hemiscalp. These results are compatible with the multiple-generator model of MMN. The attention-related role of the MMN is discussed, suggesting comparable attention mechanisms for vision and audition.

Adult↗

PubMed1998

Variable cerebral responses to equally distinct deviance in four auditory dimensions: a mismatch negativity study.

In this study we compared the amplitude, latency, and spatial distribution of the mismatch negativity (MMN), elicited by tones deviating in either frequency, intensity, stimulus-onset asynchrony (SOA) or location, and assessed inter- and intra-subject variability. Cross-dimensional comparisons were facilitated by adjusting the magnitude of deviance individually, so that the detection rates were similar, both across dimensions (within subject) and across subjects (within dimension). Despite similar detection rates, the MMN elicited by frequency deviance was larger, and the MMN elicited by SOA deviance was earlier than the other types of MMN. The reliability of frequency-related MMN was better than that of the other types of MMN. The results highlight the problems of comparing MMN across dimensions, especially in clinical populations.

Adult↗

PubMed1996

Attention factors mediating syntactic deficiency in reading-disabled children.

Syntactic context effects on the identification of spoken words, and the involvement of attention in mediating these effects, were examined in seventh-grade children with reading disabilities and children who were good readers. The subjects were asked to identify target words that were masked by white noise. All targets were final words embedded in unveiled sentences. Relative to a syntactically neutral context, the identification of targets whose morpho-syntactic structure was congruent with the context was facilitated and the identification of syntactically incongruent targets was inhibited. Reading-disabled children were less inhibited by syntactic incongruence than good readers. Presenting congruent and incongruent sentences in separate blocks reduced the amount of inhibition in good readers while having no effect on the reading-disabled. The percentage of correct identification of incongruent targets in the mixed presentation condition was larger for reading-disabled than for good readers, whereas in the blocked presentation condition the percentage of correct identification was equal across groups. The amount of facilitation was not affected by blocking the congruent and incongruent conditions, and was equal across reading groups. It is concluded that, in both reading groups, the syntactic structure of the context triggers a process of anticipation for particular syntactic categories which is based on a basic assumption that linguistic messages are syntactically coherent. Reading-disabled children are, however, less aware of this process and therefore less affected when the syntactic expectations are not fulfilled.

Adolescent↗

PubMed1996

New evidence for phonological processing during visual word recognition: the case of Arabic.

Lexical decision and naming were examined with words and pseudowords in literary Arabic and with transliterations of words in a Palestinian dialect that has no written form. Although the transliterations were visually unfamiliar, they were not easily rejected in lexical decision, and they were more slowly accepted in phonologically based lexical decision. Naming transliterations of spoken words was slower than naming of literary words and pseudowords. Apparently, phonological computation is mandatory for both lexical decision and naming. A large frequency effect in both lexical decision and naming suggests that addressed phonology is an option for familiar orthographic patterns. The frequency effect on processing transliterations indicated that lexical phonology is involved with prelexical phonological computation even if addressed phonology is not possible. These data support a combination between a cascade-type process, in which partial products of the grapheme-to-phoneme translation activate phonological units in the lexicon, and an interactive model, in which the activated lexical units feed back, shaping the prelexical phonological computation process.

Adolescent↗

PubMed1995

Semantic processing and memory for attended and unattended words in dichotic listening: behavioral and electrophysiological evidence.

Thirty-two Ss studied words presented to 1 ear, while ignoring a concurrent word list presented to the opposite ear. The N400 component of the event-related potentials elicited by attended words was modulated by semantic priming between successive words. The N400 elicited by unattended words was insensitive to semantic manipulation. Recognition memory was better for attended than for unattended words. However, the percentage of false positives was elevated equally for lures that were semantically related to "old" words, whether they had been attended or unattended. Words that were initially attended induced similar repetition effects in a lexical decision task as words that were initially unattended. Hence, both attended and unattended words are semantically processed and activate semantic representations. However, attended words from traces that are subsequently more available to conscious recollection than unattended words.

Adult↗

PubMed1995

Language-related field potentials in the anterior-medial temporal lobe: I. Intracranial distribution and neural generators.

Field potentials were recorded from intracranial electrodes in humans to study language-related processing. Subjects viewed sentences in which each word was presented successively in the center of a video monitor. Half of the sentences ended normally, while the other half ended with a semantically anomalous word. The anomalous sentence-ending words elicited a large negative field potential with a peak latency near 400 msec, which was focally distributed bilaterally in the anterior medial temporal lobe (AMTL), anterior to the hippocampus and near the amygdala. Subdural electrodes positioned near the collateral sulcus just inferior and lateral to the amygdala recorded a positive field potential at the same latency. This spatial distribution of voltage suggested that this language-sensitive field potential was generated in the neocortex near the collateral sulcus and anterior fusiform gyrus. Additional task-related field potentials were recorded in the hippocampus. The AMTL field potential at 400 msec shares characteristics with the N400 potential recorded from scalp electrodes that has been associated with semantic processing.

Action Potentials↗

PubMed1994

Attention mechanisms mediate the syntactic priming effect in auditory word identification.

The syntactic priming effect and the involvement of attention in that process were investigated by testing identification of white noise-masked Hebrew words. Targets were either syntactically congruent or syntactically incongruent with the structure of the sentence. Relative to a neutral condition, similar facilitation and inhibition was found for congruent and incongruent targets, respectively. When syntactic congruency was blocked, the inhibition was attenuated, whereas the facilitation remained the same. A 350-ms silent interstimulus interval between context and target increased inhibition without affecting facilitation. We suggest that both the facilitation and the inhibition effects of syntactic priming are based on a veiled controlled process of generating expectations. The inhibition results from a controlled process of reevaluation that requires additional attention resources.

Acoustic Stimulation↗

PubMed1994

Morphological analysis of disrupted morphemes: evidence from Hebrew.

In concatenative languages such as English, the morphemes of a word are linked linearly so that words formed from the same base morpheme also resemble each other along orthographic dimensions. In Hebrew, by contrast, the morphemes of a word can be but are not generally concatenated. Instead, a pattern of vowels is infixed between the consonants of the root morpheme. Consequently, the shared portion of morphologically-related words in Hebrew is not always an orthographic unit. In a series of three experiments using the repetition priming task with visually presented Hebrew materials, primes that were formed from the same base morpheme and were morphologically-related to a target facilitated target recognition. Moreover, morphologically-related prime and target pairs that contained a disruption to the shared orthographic pattern showed the same pattern of facilitation as did nondisrupted pairs. That is, there was no effect over successive prime and target presentations, of disrupting the sequence of letters that constitutes the base morpheme or root. In addition, facilitation was similar across derivational, inflectional and identical primes. The conclusion of the present study is that morphological effects in word recognition are distinct from the effects of shared structure.

Humans↗

PubMed1993

Electrophysiological evidence for task effects on semantic priming in auditory word processing.

Event-related brain potentials (ERPs) associated with semantic relatedness were recorded in two auditory word recognition tasks. In the Memorize task, subjects listened to a list of words in anticipation of a subsequent recognition test. In the Count Nonwords task, subjects silently counted the number of nonwords occurring within a list of words. Within each list, target words were either semantically related or unrelated to the immediately preceding word. As in comparable visual tasks, the amplitude of a negative ERP component (N400) was significantly attenuated when targets were preceded by semantically related primes. This attenuation was greater in the Memorize than in the Count Nonwords task. These data are consistent with the view that the sensitivity of N400 amplitude to semantic relatedness is modulated by task variables that manipulate depth of processing.

Adult↗

PubMed1992

Processing phonological and semantic ambiguity: evidence from semantic priming at different SOAs.

Disambiguation of heterophonic and homophonic homographs was investigated in Hebrew using semantic priming. Ambiguous primes were followed by unambiguous targets at 100 ms, 250 ms, and 750 ms stimulus onset asynchrony (SOA). Lexical decision for targets related to the dominant phonological alternatives of heterophonic homographs were facilitated at all SOAs. Targets related to subordinate alternatives were facilitated only at SOAs of 250 ms or longer. When the primes were homophonic homographs, semantic relationship facilitated lexical decision of targets at all SOAs regardless of the dominance of the meaning to which the targets were related. These data can be accounted for by assuming multiple lexical entries for heterophonic homographs, single lexical entries for homophonic homographs, and phonological mediation of accessing meanings. Language-specific factors probably account for the long-lasting activation of subordinate meanings.

Attention↗

PubMed1992

Memory with and without awareness: performance and electrophysiological evidence of savings.

Event-related potentials (ERPs) recorded on the scalp were shown to be sensitive indicators of the strength of a memory trace on both implicit and explicit tests of memory. In explicit recognition tests, the amplitude of a positive potential identified as P300 was larger for "old" than for "new" words regardless of whether the subject categorized the items correctly. This effect, however, was statistically reliable only when the recognition memory (d') was relatively high. In contrast to ERPs, the reaction times in explicit recognition were sensitive to accuracy but not to repetition. In implicit tests, lexical decisions to repeated words were faster than to newly presented words. The magnitude of the repetition effect varied neither with elapsed time since the last repetition nor with the number of previous repetitions. In contrast, the P300 elicited by the same words were sensitive to both lag and recency of repetition, suggesting that they were influenced by the episodic memory strength of the items.

Adult↗