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Biomedical subjects

S Bosković

Publications and source records attributed to S Bosković.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Results in the use of blood components separated by cytophoresis in leukemia treated with cytostatics (our 1st experiences with flowing-effect centrifuge)].

Since the essence of the malign process is still unknown, together with the basic causal principle (or principles?) of the pathological, malign growth, we, are not in position to apply the adequate, the only correct causal therapy with leukosis. As a consequence, we have numberous therapeutical diagrams with leukosis. As a consequence, we have numerous therapeutical diagrams in which there is adomination of pharmacological substances having cytostatic effects of anti-microbal, substitutional and symptomatical therapies. Cytostatics represent an expressedly different therapy. Various, very powerful cytostatic combinations and procedures applied with a desire to bring the patient into remission often cause the therapeutist to have another, very important problem: how to prevent the haematological complications using the cytostatic therapy, primarily the leukopenia and thrombocytopenia which, in bodies damaged by malign processes, can cause difficult complications. In order to avoid these, a series of new methods have been developed within the cytophoresis and haemotherapy. With the advent of separators of blood components it seems that the problem of selective and precise haemotherapy has been solved completely. Namely, if the components are applied precisely, in the stage when the patient lacks them in the desired concentration, the possibility of manifold therapeutical applications offer a possibility for an adequate subtitutional therapy. This paper brings forward our initial results from this field. The CENTRIFUGE-- AMINCO was used for seperation. The seperation in it takes place in a closed system (infection impossible), and thanks to special construction which simulates the internal medium of blood vessels, the mechanical decay of tangible components in the extracorporal medium has been reduced to a minimum. By means of adjustment of peristaltic pumps, the desired seperation is possible to be achieved. Concentrated components obtained by means of separation (leukocytes and thrombocytes, separated or together), have been applied with patients having leukosis once or several times, in the stage when they, due to cytostatic treatment, had very low values of these components with the existing or threatening complications. The substitional therapy has been applied with 14 patients and very efficient effects have been observed.

Acute Disease↗
PubMed1975

[Current state of blood transfusion in Yugoslavia and its perspectives].

The current situation of the transfusion service in this country has been characterised by small-scale operational level, the lack of regional system and basic components of a single service. There is a great variety in the medical and expert point of view starting from the lack of elementary hygienic and technical conditions, down to developed institutions of the European level. This activity has been characterised for the last ten years or so by an effort to win blood-givers at all cost, to enhance production of intravenous solutions which in some factories have obtained factory production volume, to determine basic blood groups and a very modest diagnostics for haemolitic diseases of newly born children. A large number of doctors--transfusiologists have obtained specialists' titles, but without any prospects to change the present status of their work: blood conservation, efforts to win blood-givers and determine blood groups. The differentiation between transfusiologists and clinic-engaged personnel has been increasing, thus making the transfusiologists to be far from the problems of modern haematology and clinical therapy. Observing the situation and status of transfusiology in the developed countries of Western Europe, it is possible to state that the transfusiology is developing in the direction of cooperation and team-work with doctors engaged in clinics. Therefore, cooperation with doctors engaged in clinics should be cultivated and organise team work. The intermediary role of doctors-transfusiologist in the cycle of health improvement should be avoided by all means. 90% of packed blood in this country is consumed in the form of full blood or dry plasma and only 10% in the form of desired derivatives, instead of the contrary case, since the precisely set therapy using new haemostatic medicaments is an economical imperative. The electronic data processing of blood-givers enables doctors-transfusiologists to deal with these problems since this is much cheaper and more efficient than when it was done by the doctor. Application of plactic casings, its industrial production, use of multi-channel electronic systems when determining the blood-groups and anti-bodies, makes this more of a technical than medical problem dealt by doctors. Production of intravenous solutions and plasma drying requires an inter-republican integration into a powerful industrial group, similar to that in Great Britain. Our transfusiologist should in future be engaged in business done by pathologists related to problems of blood patho-physiology, similar to the activities done in USA and other Anglo-Saxon countries. Integration of American Association of Blood Banks with the Association for organs and tissue transplation in USA only underlines this...

Blood Donors↗
PubMed1975

[Bacteriological control of blood preservation, production of infusion solutions and dry human plasma under conditions of aseptic work and possible sources of their contamination].

In premises for blood conservation, production of dry human plasma and infusion solutions "notwithstanding the permanent measures for desinfection, new bacterial contamination occurs from time to time and whose source are the casings and material originating from non-sterile environment. Bacteriological control, which has primarily a preventive character, enables a due forecast for measures to be undertaken by the appropriate desinfection of the working surfaces and air, satisfactory conditions of aseptic work can be maintained. General hygiene should be paid attention to as well as mechanical cleansing of premises, avoidance of groups for lunch-time etc., since the treatment by desinfectors would not be sufficient for maintenance of aseptic working conditions. In order to prevent the transmission of bacterial contamination, premises for blood conservation should be strictly separated from other operations and also prevent the unnecessary movements of personnel through corridors. The results of the bacteriological control of the personnel show that greater attention should be paid to their health care since the workers there work in closed aseptic systems and thus avoid them as a bacteria transmittors in respect to danger of blood and dry human plasma contamination. It is also necessary to efficiently educate the personnel for work in aseptic conditions and also increase their elementary knowledge from bacteriology and hygiene. The bacterial skin-flora on the spot of donor's venepuncture also presents a certain danger for blood contamination. Therefore, it is necessary to establish the most optimal manner of skin desinfecate together with the most appropriate means having a fast bactericidal and fungicidal action. It would also be useful, on the basis of further test, to suggest certain standard for an allowed number of conditionally pathogenic and saprophytic microorganisms which would be used by the instutions performing the blood transfusion and production of the intravenous solutions during their bacteriological controls.

Antisepsis↗
PubMedDate not supplied

[Henoch-Schoenlein purpura with pulmonary infiltration].

Purpura Henoch-Schönlein (PHS) was described in 55-year old man. The damages of skin, joints, gastrointestinal tract, kidneys and lung were found. The spreading of the PHS into the lungs with the development of transitory respiratory failure was found out on X-ray finding (bilateral pleural effusions and interstitial infiltrations), functional testing (differential diffusing capacity of alveolar membrane reduced to 31% of normal) and with measurement of blood gases (hypoxemia with PaO2 43.8 mmHg respectively 5.7 kPa). The impairment of lung function is rarely described since according to the data from the literature the lungs are damaged only in 6.5% of patients with PHS. Due to the corticosteroid therapy all clinical and laboratory findings were significantly improved.

Humans↗