Biomedical subjects
Publications and source records attributed to S Carozzi.
The rational and selective use of the perioperative antibiotic prophylaxis plays a decisive role in prevention of post-operative infections in orthopedic surgery and traumatology. The conceptual bases for the application of the Short-Term chemioprophylaxis are presented in accord to the most recent data reported in the literature.
Authors describes the Baker's surgical gastrocnemius lengthening of equinus deformity in cerebral palsy. Results and surgical Technics related to clinical situation of patients are presented.
Authors report a case of so called Proximal Femoral Focal Deficiency. After remembered different classifications, histological, clinic and radiological findings of this anomaly and analyzed some aspect of the treatment.
Authors describes biomechanics, etiopatogenetics and clinical aspects of carpal injury, which given at an radio-carpic instability.
Authors report a preliminary results of omo and ethero-neuro grafts in rats and rabbit.
In 55 patients who underwent renal transplantation, erythrocytosis (E) was observed in 6. In all patients, the growth of erythroid progenitors [burst-forming unit erythroid (BFU-e)], using mononuclear blood cells, was evaluated in in vitro cultures. The results showed a significant increase of serum erythropoietin (s-Ep) in erythrocytosis and in nonerythrocytosis patients with a subsequent decrease when hematocrit (Hct) and hemoglobin (Hb) reached high levels, showing a recovery of a feedback control system. Notwithstanding the diminution of s-Ep, six patients demonstrated further progressive rise of the Hct and Hb to a final state of E. The in vitro BFU-e cultures from these patients showed a noticeable sensitivity to progressively reduced doses of Ep and also the capacity to develop a few colonies when the medium was Ep-free. These results were not verified using peripheral blood depleted of monocyte and/or T lymphocyte cells. Therefore, in transplanted patients with erythrocytosis, it is possible that particular cellular interactions stimulate an early hyperproliferation of BFU-e with a greater Ep sensitivity and at least partly the capacity to grow also in the absence of Ep.
The T lymphocytes, OKT4-depleted T lymphocytes, monocytes, macrophages and the bone marrow early erythroid progenitor (BFU-E) interactions have been evaluated in normal subjects and in uremic patients in predialysis phase (PDP), on hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). In the same subjects the T-cell growth factor (TCGF) activity and the T-cell subset identification have also been assessed. The results show in uremic patients, particularly in the presence of reduced OKT4 subset and TCGF activity, a blockage of the interactions between immunocompetent and bone marrow cells which normally could stimulate early erythroid progenitor growth. Since this blockage is partially removed by CAPD, this may suggest a more efficient removal of an interaction inhibitor with CAPD than with other dialysis techniques. The mechanism by which such a material may act appears unclear, but it is possible to suppose an inhibiting activity on the production of TCGF by lympho-monocyte cells which under normal conditions could be considered as an early erythropoiesis regulatory factor.
Serum erythropoietin increased in 55 patients after transplantation. The serum erythropoietin decreased when the haematocrit and haemoglobin reached high levels, indicating recovery of a feed-back control system. Despite the diminution of erythropoietin, six patients demonstrated a state of erythrocytosis while the in vitro cultures of BFU-e revealed high sensitivity to the reduced doses of erythropoietin, using monocyte-free T-lymphocyte-depleted peripheral blood. In polycythaemic transplanted patients it is possible that cellular interactions stimulate an early hyperproliferation of BFR-e with a greater erythropoietin sensitivity and a partial capacity to grow in the absence of erythropoietin.
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The authors after remembered shortly, mechanical and biological factors which can determine beginning of carpus scaphoid pseudoarthrosis, described the surgical techniques more frequently used confirmed the important idea of the stable osteosynthesis for a recovery fast and completely.
In this work the authors want to illustrate the different injuries of the collateral ulnar ligament in the thumb and his following surgical treatment at the light of the most modern discoveries in this field.
In this research the early erythroid progenitor (BFU-E) growth has been observed in patients with chronic renal failure by studying in "in vitro" cultures the number of BFU-E developed per plate under various experimental conditions. Our results demonstrate that the BFU-E growth of uremic patients in the predialysis phase or on hemodialysis is suppressed both in basal conditions and with the addition of lympho-monocytes of normal subjects or CAPD patients to the "in vitro" cultures. In CAPD patients, on the contrary, the BFU-E growth appears near normal levels in basal conditions and is further more enhanced by adding the normal lympho-monocytes to the "in vitro" cultures. The above mentioned facts signify that in uremic patients both the abnormality of bone marrow and immunocompetent cells may be responsible for the suppressed BFU-E growth, while with CAPD the improvement of both systems allow a normalisation of erythropoiesis. Such a recovery with CAPD demonstrates the presence of an inhibitor material in uremia which is better depurated by this technique.
The Author speak about 2 cases of MC. poly fragmentary fractures treated with Fibrin glue. There are optimal results in a short time (25-30 days) and in a long time (50-60 days).
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The author think that "Fibrin Seal Glue" and mechanical syntesis is an opimal method for osteosintesis of the Carpal scaphoid. He speaks about 5 patients treated with optimal results in 50 days mean.
The author speaks about the treatment of the enchondroma of the hand, and report on 15 cases treated with curettage plus grafting: in 12 cases with bone auto-graft, in 2 cases with bone homo-graft; in 1 cases with amputation of 2 finger and 3 finger put in place of 2 finger. The results are optimal in 50-60 days mean at X ray control.
Chronic renal failure anemia noticeably improves only in patients who undergo CAPD treatment. In order to understand why it is so, the behaviour of some hematological parameters and the weekly clearances of creatinine and peak 7c1 were studied in the course of hemodialysis (HD) and CAPD. Our study shows that an improvement in hematological data is obtained in patients undergoing CAPD but not in those undergoing HD: this result is directly correlated with the increase of the peak 7c1 weekly clearance. Since the serum erythropoietin values are not modified, the improvement of the anemia appears to be related to the reduction of the biochemical abnormality of uremia using a better qualitative or quantitative depuration of bone marrow activity inhibitory material by CAPD.
An optimal treatment for the fracture of the 3rd phalanx, only, or with lesion of the ongle and skin, by means of Stack's monodigital splint is presented.