Biomedical subjects
Publications and source records attributed to S Carozzi.
The Author refer about a pain syndrome of the wrist, characterized by nerve interosseous radial compression at carpal. A surgical enervation gives in all patients treated, a total remissione of pain.
The Author describes a case of supernumetary metatarsos with hypoplasy of the little finger of the foot and pseudoarthrosis of the 5th metatarsus. Is very important an early surgical treatment.
The validity of surgical treatment about "Mallet finger" with avulsion of tendon insertion (Bush lesion's) is presented. Are exposed 25 cases treated from 1980 to January 1983 with optimal results.
The author described a case of non-union of the tuft of the distal phalanx of the 3 finger, treated by open reduction Kirschner wire fixation and spongious bone homo-graft. The type of non-union and his treatment is discussed.
The author speaks about Duplication of the Thumb and his surgical treatment. He report 10 cases treated. Is very important an early surgical treatment to obtain a good aesthetic and functionally result.
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In this search the serum and dialysis fluid of psoriasic patients in comparison with those of normal and uremic subjects have been evaluated by gel-filtration through a Sephadex G-15 column. The results showed a storage of the substances with various molecular weight in these patients. Particular attention was addressed to those with MW less than 1500 because they are not generally present in the normal subjects, decrease in the serum of psoriasic and uremic patients during the dialytic therapy, simultaneously with positive effects on the clinical symptomatology.
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Skin-muscle and kidney biopsy specimens were obtained from 43 patients with glomerulonephritis and from 5 normal subjects. 14 of the 43 patients had mesangial IgA nephropathy and in 12 the immunofluorescence study of skin-muscle biopsy showed IgA deposits. Ultrastructural research performed on 4 of these patients showed some electron-dense deposits on the walls of the muscular capillaries or in the perivascular connective tissue which could represent the immune aggregates. The remaining 29 patients had nonsystemic chronic glomerulonephritis with various immune deposits; only in 7 of these patients was the immunofluorescence study positive. The said study suggests that immunofluorescence examination of skin-muscle biopsy specimens could be diagnostically important.
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We have demonstrated in some continuous ambulatory peritoneal dialysis (CAPD) patients with ultrafiltration (UF) loss, the role of increased peritoneal lymphocyte (PLy) and macrophage (PMO) Ca++ concentrations in the release of large amounts of gamma-interferon (gamma-IFN) and Interleukin-1 (IL-1), which stimulate peritoneal fibroblast proliferation. We have also shown in vitro and in vivo that the calcium channel blocker verapamil (VPM) is able to normalize the previously high PLy and PM0 Ca++ concentrations, and cytokine release; to decrease fibroblast proliferation; and to increase UF in 60% of the CAPD patients with UF loss due to a cytokine-mediated hyperproliferation of peritoneal fibroblasts, while in the remaining 40% there is little improvement (VPM responders and low-responders, respectively). To evaluate which mechanisms, in addition to passive Ca++ influx, can play a role in the Ca++-dependent activation of peritoneal immune cells, we evaluated the effects in vitro of different doses of Ca++ alone; with VPM; and with 1,25(OH)2D3 on: 1) PLy and PM0 cytoplasmic Ca++ levels; 2) gamma-IFN and IL-1 release by PLy and PM0; and 3) peritoneal fibroblast proliferation in six CAPD VPM low-responder patients. Results showed a direct correlation between Ca++ levels in the medium and PLy and PM0 Ca++ concentrations; IL-1 and gamma-IFN release; and peritoneal fibroblast proliferation. These effects were enhanced by the addition of low doses of 1,25(OH)2D3 to the medium, while both high 1,25(OH)2D3 doses and verapamil abrogated the Ca++-induced PLy and PM0 activation.(ABSTRACT TRUNCATED AT 250 WORDS)
In CAPD patients with relapsing bacterial peritonitis who do not benefit from intraperitoneal therapy with IgG (IgG nonresponders), the authors demonstrated that peritoneal macrophages are deficient in IgG Fc receptors (FcR) and, therefore, unable to kill bacteria, independent of the levels of the opsonic molecule IgG in the peritoneal dialysis effluent (PDE). Because previous studies showed that interferon-alpha (IFN-alpha) is able to increase in vitro the number of PM0 IgG FcR in CAPD patients with relapsing bacterial peritonitis, the authors studied the in vivo effects of IP administration of IFN-alpha (1,000 IU daily in the overnight exchange for 12 months) on: PM0 superoxide generation; PM0 bacterial killing; PM0 IgG FcR; the number of bacteria in the PM0 cytoplasm; and peritonitis relapses in these patients. By the 10th day, IFN-alpha induced a progressive rise in all of the previously depressed PM0 functions tested, the disappearance of bacteria from the PM0 cytoplasm, and no further episodes of bacterial peritonitis were detected during 12 months. These data indicate that IFN-alpha may represent a useful tool for preventing infections in CAPD patients with relapsing bacterial peritonitis.