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Biomedical subjects

S Chatterji

Publications and source records attributed to S Chatterji.

At least 19 recordsLinked to original sources

Self-generation of concentration gradients of divalent cations in commercial bentonite membrane during ultrafiltration.

Research workers, working with commercial bentonite-based membranes, reported different diffusivity for co- and counterions through those membranes. Many of these researchers called this difference in diffusivity ultrafiltration. Some of these workers also noted that commercial bentonite membranes often contain divalent metal carbonates as impurities. Recently it has been suggested that the ultrafiltration is associated with the co-diffusion of divalent metal ions. Previous workers did not recognize this co-diffusion, probably due to an absence of imposed concentration gradient for the divalent metal ions. The present investigation suggests that the required concentration gradient is self-generated by increased solubility of the divalent metal carbonates with increasing concentration of alkali halide in solution. The presence of dissolved divalent metal ions alters the interfacial potentials at the outside solution and bentonite membrane junctions and reduces the electrostatic potential gradient across the membrane. A reduction in the electrostatic potential gradient across the membrane reduces the coupling between the diffusing co- and counterions and alters their diffusivity.

Letter↗

Aspects of ionic diffusion through thick matrices of charged particles.

A review of the literature on ionic diffusion through matrices of charged particles shows that many workers have reported higher diffusivity of co-ions than of counterions. If these observations are correct then the requirement of electroneutrality of bulk solutions is violated. In those experiments other, not looked for, ions must have been taking part. It therefore appears that complete chemical analyses of solutions of both up- and downstream sides should be carried out, otherwise misleading inferences may be drawn, with practical consequences. Some researchers have studied transport of water under osmotic pressure differentials across clay membranes. However, a diffusing ion, during its transport from higher concentration to lower concentration, always carries its water of hydration. This second water transport process has not received attention. This suggests that at a critical concentration two transport processes will cancel each other. Attention has been drawn to this second type of water flow and its consequences. In ionic diffusion, each side of the membrane-outside solution interface is subject to the effects of the Nernst layer and Donnan zone. However, these layers and zones are seldom treated quantitatively. This has been carried out in this paper by two different methods. Both methods give identical thicknesses of the Nernst layer and Donnan zone. Finally, the effects of the presence of soluble bivalent salts on the diffusivity of different types of ions have been commented up on. In these cases some of the co-ions diffuse to the upstream side.

Journal Article↗

Upper limits on a stochastic background of gravitational waves.

The Laser Interferometer Gravitational-Wave Observatory has performed a third science run with much improved sensitivities of all three interferometers. We present an analysis of approximately 200 hours of data acquired during this run, used to search for a stochastic background of gravitational radiation. We place upper bounds on the energy density stored as gravitational radiation for three different spectral power laws. For the flat spectrum, our limit of omega0 < 8.4 x 10(-4) in the 69-156 Hz band is approximately 10(5) times lower than the previous result in this frequency range.

Journal Article↗

Limits on gravitational-wave emission from selected pulsars using LIGO data.

We place direct upper limits on the amplitude of gravitational waves from 28 isolated radio pulsars by a coherent multidetector analysis of the data collected during the second science run of the LIGO interferometric detectors. These are the first direct upper limits for 26 of the 28 pulsars. We use coordinated radio observations for the first time to build radio-guided phase templates for the expected gravitational-wave signals. The unprecedented sensitivity of the detectors allows us to set strain upper limits as low as a few times 10(-24). These strain limits translate into limits on the equatorial ellipticities of the pulsars, which are smaller than 10(-5) for the four closest pulsars.

Journal Article↗

Ionic diffusion through thick matrices of charged particles.

Ionic diffusion through thick beds of charged matrices occurs in many fields. Ionic transport is driven by electrochemical potential gradient, i.e., it is a combined result of chemical potential gradient and electrical potential gradient. To clarify a number of unexplained observations, the steady state diffusion of NaCl and LiCl solutions through 76-mm-thick Na- and Li-bentonite pastes, reported by Dutt and Low, has been critically analyzed. The analyses showed that in the pastes the concentrations of M+ ions are much higher than those of Cl- ions. The phenomenological diffusivity of cation and anion are the same. Decomposition of the phenomenological ion flux into parts due to chemical and electrical potential gradients shows that the chemical diffusivity of the anion is higher than its phenomenological diffusivity. Cations are the other way round. The electric potential gradient created by the concentration gradient of ions causes these changes. Phenomenological and chemical diffusivity are concentration-dependent and are related by an equation of the type Y=A-B square root of c, where A and B are constants and c is the molar concentration of the ion. This relation is due to Coulomb's law modeling of ion-ion interaction. The above inferences have bearing on the fields of ground water contamination, durability of cement-based materials, construction of clay-lined waste landfills, and construction of nuclear deposits.

Journal Article↗

Global burden of depressive disorders in the year 2000.

BACKGROUND: The initial Global Burden of Disease study found that depression was the fourth leading cause of disease burden, accounting for 3.7% of total disability adjusted life years (DALYs) in the world in 1990. AIMS: To present the new estimates of depression burden for the year 2000. METHOD: DALYs for depressive disorders in each world region were calculated, based on new estimates of mortality, prevalence, incidence, average age at onset, duration and disability severity. RESULTS: Depression is the fourth leading cause of disease burden, accounting for 4.4% of total DALYs in the year 2000, and it causes the largest amount of non-fatal burden, accounting for almost 12% of all total years lived with disability worldwide. CONCLUSIONS: These data on the burden of depression worldwide represent a major public health problem that affects patients and society.

Adult↗

The Mennen femoral plate for fixation of periprosthetic femoral fractures following hip arthroplasty.

Periprosthetic fractures can be treated by various methods. The Mennen femoral plate used to be a common implant in our region to stabilise periprosthetic femoral fractures following hip arthroplasty. This device has been used in 16 patients in our region from three different centres. The periprosthetic femoral fractures occurred approximately 7 years after the hip arthroplasty procedure. After stabilisation of the fracture, patients were kept non-weight bearing. Weight bearing was commenced once there was clinical and radiological evidence of fracture union. About 75% of our patients had a complication following fixation of the fracture. In all of these patients the main complication was varus mal-union of the fracture. As per our study the Mennen femoral plate seems to be a weak fixation device. The plate is unable to counter the medial compressive forces on the femur leading to a varus collapse of the fracture.

Accidental Falls↗

Multiple-informant ranking of the disabling effects of different health conditions in 14 countries. WHO/NIH Joint Project CAR Study Group.

BACKGROUND: The Global Burden of Disease study provided international statistics on the burden of diseases, combining mortality and disability, that can be used for priority setting and policy making. However, there are concerns about the universality of the disability weights used. We undertook a study to investigate the stability of such weighting in different countries and informant groups. METHODS: 241 key informants (health professionals, policy makers, people with disabilities, and their carers) from 14 countries were asked to rank 17 health conditions from most disabling to least disabling. Kruskal-Wallis ANOVA was used to test for differences in ranking between countries or informant groups and Kendall tau-B correlations to measure association between different rank orders. FINDINGS: For 13 of 17 health conditions, there were significant (p<0.05) differences in ranking between countries; in the comparison of informant groups, there were significant differences for five of the 17 health conditions. The overall rank order in the present study was, however, almost identical to the ranking of the Global Burden of Disease study, which used a different method. Most of the rank correlations between countries were between 0.50 and 0.70 (average 0.61 [95% CI 0.59-0.64]). The average correlation of rank orders between different informant groups was 0.76. INTERPRETATION: Rank order of disabling effects of health conditions is relatively stable across countries, informant groups, and methods. However, the differences are large enough to cast doubt on the assumption of universality of experts' judgments about disability weights. Further studies are needed because disability weights are central to the calculation of disability-adjusted life years.

Analysis of Variance↗

Models of disablement, universalism and the international classification of impairments, disabilities and handicaps.

A review and critique of models of disability is presented, tracing the development of frameworks and classificatory instruments (International Classification of Impairments, Disabilities and Handicaps) over the past 20 years. While the 'social' model is now universally accepted, it is argued that universalism as a model for theory development, research and advocacy serves disabled persons more effectively than a civil rights or 'minority group' approach. The development of the revised International Classification (ICIDH-2) is discussed in this light.

Activities of Daily Living↗

Factor structures for DSM-IV substance disorder criteria endorsed by alcohol, cannabis, cocaine and opiate users: results from the WHO reliability and validity study.

AIMS: The factor structure of DSM-IV substance disorder criteria is examined among alcohol, cannabis, cocaine and opiate users to determine the dimensionality of abuse and dependence criteria within each of these drug classes and whether a common construct can be generalized across drug classes. DESIGN: 12-month criterion prevalence was assessed as part of the World Health Organization's Study on the Reliability and Validity of the Alcohol and Drug Use Disorder Instruments in various settings at eight sites around the world using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN). A majority of respondents were recruited from non-treatment settings. In addition to exploratory factor analysis, confirmatory factor analysis was used to analyse factor structures using weighted least square methods and tetrachoric correlation matrices. Multi-sample analysis techniques were used to model differences between drug-classes. FINDINGS: In the full data analyses identified a single factor solution for each user population and across user populations. However, analyses of data from users reporting low to moderate symptomatology identified a two-dimensional construct among alcohol, cannabis and opiate users consisting of a major "dependence" factor and a lesser "abuse" factor. In addition, results showed that neither the abuse criterion "(A2) use in physical hazardous situations" or the dependence criterion "(D7) use despite knowledge of psychological/physical problems" were central to the latent construct in any of the user populations, except for D7 among alcohol users. CONCLUSIONS: The multi-dimensional results found among users with low to moderate symptomatology indicate that: (1) previous results from relatively homogeneous populations may have been biased towards lesser order solutions, and that (2) the DSM-IV substance disorder criteria describe at least two distinct phenomena, supporting the current DSM-IV organization of substance disorder criteria. Further work needs to evaluate whether prevalent symptoms are present in random or predictable combinations, whether combinations reflecting a specific hierarchy of severity can be identified, and whether incident symptoms are accumulated in a predictable pattern, within specific user populations and across user populations.

Alcoholism↗

Reliability of the Romanian version of the alcohol module of the WHO Alcohol Use Disorder and Associated Disabilities: Interview Schedule --Alcohol/Drug-Revised.

Alcohol Use Disorder and Associated Disabilities Interview Schedule - Alcohol/Drug-Revised (AUDADIS-A/D-R) is a fully structured, standardized and precoded instrument designed to evaluate alcohol and drug use disorders according to DSM-III-R, DSM-IV, and ICD-10 criteria. The AUDADIS-A/D-R has shown good to excellent reliability in both large clinical and general population samples, but prior to the conduct of the present study no data on the reliability of the Romanian version of the AUDADIS-A/D-R existed. The purpose of the present study was to examine the test-retest reliability of the alcohol module of the AUDADIS-A/D-R in a general population and clinical sample in Romania. The overall reliability of ICD-10 and DSM-IV abuse, harmful and dependence diagnoses, was found to be good to excellent, but was somewhat lower for abuse and harmful use diagnoses. The results are discussed in terms of the cultural applicability of the symptom items and within the context of the analysis of discrepant responses between the test and retest interviews.

Adult↗

WHO Study on the reliability and validity of the alcohol and drug use disorder instruments: overview of methods and results.

The WHO Study on the reliability and validity of the alcohol and drug use disorder instruments in an international study which has taken place in centres in ten countries, aiming to test the reliability and validity of three diagnostic instruments for alcohol and drug use disorders: the Composite International Diagnostic Interview (CIDI), the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and a special version of the Alcohol Use Disorder and Associated Disabilities Interview schedule-alcohol/drug-revised (AUDADIS-ADR). The purpose of the reliability and validity (R&V) study is to further develop the alcohol and drug sections of these instruments so that a range of substance-related diagnoses can be made in a systematic, consistent, and reliable way. The study focuses on new criteria proposed in the tenth revision of the International Classification of Diseases (ICD-10) and the fourth revision of the diagnostic and statistical manual of mental disorders (DSM-IV) for dependence, harmful use and abuse categories for alcohol and psychoactive substance use disorders. A systematic study including a scientifically rigorous measure of reliability (i.e. 1 week test-retest reliability) and validity (i.e. comparison between clinical and non-clinical measures) has been undertaken. Results have yielded useful information on reliability and validity of these instruments at diagnosis, criteria and question level. Overall the diagnostic concordance coefficients (kappa, kappa) were very good for dependence disorders (0.7-0.9), but were somewhat lower for the abuse and harmful use categories. The comparisons among instruments and independent clinical evaluations and debriefing interviews gave important information about possible sources of unreliability, and provided useful clues on the applicability and consistency of nosological concepts across cultures.

Adult↗