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Biomedical subjects

S Dash

Publications and source records attributed to S Dash.

126 records · Page 7Linked to original sources
PubMed1977

Combined G-6PD and 6-PGD deficiency in a Hindu boy.

A case of drug-induced haemolytic anaemia due to G-6PD deficiency is documented because of the associated asymptomatic 6-PGD deficiency--a combination probably reported only once before. Our studies of the patient's family suggest that 6-PGD deficiency is inherited through a simple autosomal dominant gene.

Anemia, Hemolytic↗
PubMedDate not supplied

Prenatal diagnosis of thalassaemia by haemoglobin chromatography on Biorex. An evaluation of the method.

The applicability of the chromatographic separation of haemoglobin F, A and S on Biorex 70 ( Blouquit et al., 1982) for the prenatal diagnosis of thalassaemia and related conditions was evaluated in comparison to the conventional globin chain separation technique. The method proved reliable, inexpensive and rapid and should be considered as a valuable alternative in laboratories carrying out great numbers of tests and those being newly set up for this purpose.

Cation Exchange Resins↗
PubMedDate not supplied

Effectiveness of alpha,beta-arteether in acute falciparum malaria.

With the emergence of widespread chloroquine resistance and a world-wide scarcity of quinine, a search for newer antimalarial drugs has become imperative. Different derivatives of qinghaosu have been successfully tried. alpha,beta-Arteether, an ethyl derivative of qinghaosu, was administered to 51 patients with Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1-4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52.04 h (standard deviation 27.09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences. alpha-beta Arteether was a safe, effective and convenient drug for treating P. falciparum malaria. This is the first clinical study with arteether in falciparum malaria.

Adolescent↗
PubMedDate not supplied

alpha, beta-Arteether for the treatment of complicated falciparum malaria.

alpha, beta-Arteether is an ethyl ether derivative of artemisinin which is an efficient schizontocidal drug in mild falciparum malaria. The present study reports the efficacy of the drug in severe falciparum malaria. Fifty patients with severe falciparum malaria were given intramuscular arteether, 150 mg, once daily on 3 consecutive days. The median fever clearance time was 72 h (range 12-120 h) and the median parasite clearance time was 2 d (range 1-4 d). Rapid recovery from coma was observed in cerebral malaria patients (after a median of 18 h, range 6-72 h). The recovery from other complications was also faster and complete. Two patients died; both had cerebral malaria and haemolytic jaundice, one had respiratory distress needing ventilatory support and the other had severe anaemia. Recrudescence within 28 d was observed in 7 patients. Drug toxicity or significant side effects were not noticed in any patient.

Antimalarials↗
PubMedDate not supplied

Polymerized albumin binding to serum in various liver diseases: its significance and relation to hepatitis B virus infection.

Sensitive and specific enzyme-linked immunosorbent assays (ELISA) were developed to detect separately the binding of polymerized human serum albumin (PHSA) to its antibody (A-PHSA) and to the hepatitis B surface antigen (HBsAg). A-PHSA was not detected in normal serum, whereas more than one-third to about half of sera from patients with acute liver cell injury showed this antibody. Frequency of A-PHSA positivity was low in chronic liver diseases, being relatively higher in those with continuing liver injury. A-PHSA detection was not related to seropositivity for HBsAg. PHSA binding of HBsAg positive sera showed a higher frequency of positivity in chronic carriers than acute hepatitis B. Of 172 asymptomatic HBsAg carriers, PHSA binding was demonstrated in 25 (15%), the frequency being significantly high if HBeAg was also present (84%). Binding was infrequent in sera having anti-HBe (2.9%) and in those negative for both HBeAg and anti-HBe (2.7%). Binding of HBsAg to PHSA was significantly higher than to human serum albumin (HSA). Immunoblotting of separated HBsAg components showed PHSA binding specifically to the high molecular weight peptide. PHSA binding in HBsAg positive serum may indicate the latter's infectivity as detected in a study of maternal-fetal transmission, where it demonstrates 100% infectivity in HBsAg and HBeAg positive mothers. PHSA possibly mediates the attachment of the HBV to the hepatocyte and a competitive binding between A-PHSA with HBsAg for PHSA may modulate the course of HBV infection.

Antibodies↗
PubMedDate not supplied

Pedunculated angiomyxoma of the vulva - a rare clinical entity.

BACKGROUND: Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. Since its initial description in 1983, approximately 65 cases have been reported in the English literature. CASE: A 33-year-old parous woman with a slow growing pedunculated soft tissue tumour of the vulva which later underwent surface ulceration. Pathological findings in the case were suggestive of an aggressive angiomyxoma, a distinctive soft tissue non-malignant tumour, which could, at times be locally aggressive.

Adult↗
PubMedDate not supplied

Correlation of smoking behaviour and blood carboxyhaemoglobin in bidi and cigarette smokers.

Effects of different variables (amount, number of puffs, depth of inhalation, length and timing of sampling) of smoking on the blood carboxyhaemoglobin (COHb) levels were studied. There were 27 bidi smokers, 25 cigarette smokers, 25 mixed smokers (all asymptomatic) and 20 symptomatic cigarette smokers. Fifty-eight healthy non-smokers served as controls. The mean COHb levels in all the smokers were nearly 5-7 times higher than that in non-smokers. The blood COHb levels correlated well with the self assessed degree of inhalation by the individual smokers in each of the groups. There was no significant correlation between the COHb levels and number smoked on the test day, number of puffs per cigarette or bidi, and the length of smoking material. There was a good inverse correlation between the time interval and COHb level. The smoking index (amount smoked) did not bear any relationship with blood COHb levels.

Adult↗