PubMed Health⌕ Search

Biomedical subjects

S Friis

Publications and source records attributed to S Friis.

At least 109 records · Page 6Linked to original sources
PubMed1990

Acute inhibition of human renal tubular cell growth by cyclosporin A.

Human proximal tubular cells were isolated and grown in culture for three passages. The proliferation of these cells were inhibited by the immunosuppressive drug cyclosporin A in dose dependent manner in the range of 250 to 2000 ng/ml growth medium. The cultures with low cell density were more sensitive to cyclosporin A compared to the cultures with high density, measured by the incorporation of 3H-thymidine. The toxic effect of cyclosporin A on cells isolated from patients treated with cyclosporin A, did not differ from cells isolated from normal tissue. The calcium channel blocker, verapamil, reversed the inhibitory effect of low concentrations of cyclosporin A on cell proliferation. The electron microscopy showed that cells treated with cyclosporin A, had severe morphological alterations with rounded mitochondria and giant vesicles in the cytoplasma. The results support the hypothesis that the toxic effect of cyclosporin A may be mediated through an increased Ca++ influx into the proximal tubular cells.

Cell Division↗
PubMed1990

Can prediction of violence among psychiatric inpatients be improved?

In an effort to improve the prediction of violence among psychiatric inpatients, the authors retrospectively studied 25 patients who were violent and 34 who were not violent after admission to a psychiatric emergency ward in Norway. The only demographic variable that discriminated between the two groups was violence in the family of origin; the violent group had experienced significantly more. The best single predictor of violence was a history of previous violence by the patient, which correctly classified 80 percent of the patients. The combined information about patients' level of aggression rated at referral and level of anxiety rated at admission correctly classified 78 percent. In a subgrouping of violent patients who inflicted injuries and did not inflict injuries, a higher percentage of the injury-inflicting patients were found to have a diagnosis of schizophrenia. These patients also had a higher level of aggression at referral.

Adult↗
PubMed1989

A factor analytical study of the Comprehensive Psychopathological Rating Scale among patients with anxiety and depressive disorders.

A sample of 136 inpatients, meeting the DSM-III-R criteria for anxiety and/or unipolar depressive disorders, were rated on the 37 CPRS items designed for nonpsychotic disorders. By factor analysis we identified 2 indices: a 12-item depression index and a 7-item anxiety index. The indices proved to have good internal consistency and interrater reliability. They differentiated well between patients with anxiety and those with depressive disorders, and among subgroups of anxiety and depression. Our depression index may represent a slight improvement in specificity compared with previously suggested depression indices. Our main finding is the identification of an anxiety index with good psychometric properties.

Adult↗
PubMed1989

Immunomicroscopic localization of the 10,000 molecular weight calcium-binding protein in the human enterocyte.

The cellular localization of the 10,000 molecular weight calcium-binding protein (CaBP or Calbindin-D) in the small intestinal epithelium of man was investigated by immunofluorescence and immunoelectron microscopy (immunogold staining). Indirect immunofluorescence on frozen sections showed intracellular staining in the enterocyte. The fluorescence was evenly distributed and no significant differences were observed between crypt and villus cells. No staining was found in goblet cells or in the submucosa. Correspondingly, immunogold labeled antibodies were scattered over the cytoplasm of the enterocyte. The terminal region appeared to be the most intensely decorated and the brush border region showed labeling above the background level. No labeling was associated with intracellular membranes or the basolateral membrane.

Calcium-Binding Proteins↗
PubMed1989

Comparison between personality disorder diagnoses in DSM-III and DSM-III-R: reliability, diagnostic overlap, predictive validity.

97 nonpsychotic consecutive day patients were diagnosed by the axis 1 and 2 in the DSM-III and DSM-III-R system, and their treatment response during their stay was measured by the Health Sickness Rating Scale. The interrater reliability was equally good for both diagnostic systems. On axis 1, there were only minor differences between DSM-III and DSM-III-R. On axis 2, the frequency of schizotypal disorder was reduced by 40% and the frequency of histrionic disorder by two-thirds. The number of schizoid disorders increased from zero to five. Of the DSM-III schizotypals who lost this diagnosis in DSM-III-R (n = 8), 4 got a new diagnosis of schizoid personality and 4 maintained their borderline diagnoses. In DSM-III-R there was a sharper demarcation between patients with severe and nonsevere personality disorder with regard to treatment outcome, indicating an increased validity of these categories. There was also a sharper demarcation between borderline versus histrionic and schizotypal, and between schizotypal and schizoid diagnoses.

Adult↗
PubMed1989

Body awareness group therapy for patients with personality disorders. 1. Description of the therapeutic method.

The aim of this paper is to describe the Body Awareness Group Therapy (BAGT) designed for patients with personality disorders. The BAGT is a body-oriented small group therapy conducted by a physiotherapist and a cotherapist. The aim is to foster personal growth and development by use of individual and group exercises. The therapy is a synthesis of earlier clinical experiences, mostly based on works of Reich, on elements of encounter and of eastern body tradition.

Body Image↗
PubMed1989

Body awareness group therapy for patients with personality disorders. 2. Evaluation of the Body Awareness Rating Scale.

The Body Awareness Rating Scale (BARS) was developed to evaluate the treatment process of the Body Awareness Group Therapy. The BARS subscales proved to have high interrater reliability. A factor analysis revealed two factors which seemed to measure one awareness and one movement dimension. The BARS was sensitive to change. As hypothesized, the BARS improvement enlarged with increasing duration of treatment. At discharge the good BARS outcome patients had improved significantly more than the poor BARS outcome ones, both concerning symptoms and global psychopathology.

Adult↗
PubMed1989

The Phobic Avoidance Rating Scale: a psychometric evaluation of an interview-based scale.

An interviewer rating scale for the measurement of (agora)phobic avoidance, the Phobic Avoidance Rating Scale (PARS), is described and psychometrically evaluated. The criteria of avoidance used are purported to correct weaknesses of the sets of criteria used in self-report instruments. Two samples with inpatients satisfying DSM-III-R criteria for unipolar depressive and/or anxiety disorder were studied. Intercorrelational and factor analyses revealed 3 dimensions among agoraphobic fears: separation fears, social fears and simple phobic fears. Overall, the 3 subscales constructed from these dimensions proved to have good reliability, validity, and sensitivity to change following treatment. The internal consistency of the social subscale seemed to be somewhat low. The PARS should be well suited to assess avoidance among agoraphobic patients on separate dimensions and to distinguish patients with agoraphobia from other psychiatric patients. It seems to be the first interviewer rated agoraphobic scale that is psychometrically investigated and should ideally be used for research purposes in combination with a self-report instrument.

Adult↗
PubMed1986

Measurements of the perceived ward milieu: a reevaluation of the Ward Atmosphere Scale.

From a theoretical perspective the effect of hospital treatment depends on how the ward milieu is perceived by the patients. An objection against the measurement of patient perceptions has been that lack of reliability would invalidate the assessment. To investigate this objection 49 inpatient wards were evaluated with the Ward Atmosphere Scale (WAS). The real ward (WAS-R) scores proved to have acceptable reliability both for patients and for staff. For the ideal ward (WAS-I) scores the reliability was mostly unacceptable for both groups. The content validity of the WAS subscales was found to be acceptable by a group of experienced psychiatrists. Criterion oriented and construct validity were also acceptable, even if the WAS lacks some seemingly important variables. A comparison of WAS scores from four different countries indicated that the WAS has excellent cross-cultural properties. The WAS seems to measure fairly stable aspects of the atmosphere. The WAS scores proved to be fairly stable, even on wards where patients and staff desired considerable changes.

Cross-Cultural Comparison↗
PubMed1986

Factors influencing the ward atmosphere.

On 35 short-term wards the connection between ward atmosphere as perceived by patients and various setting and treatment characteristics was explored by the use of a hierarchical multiple regression analysis. The most important variables proved to be: mean age of patients, percentage of psychotic patients, number of patients, staff turnover rate, and interaction score. A higher mean age of patients was associated with changes in the ward atmosphere preferred by older patients. An increased percentage of psychotic patients and an increased number of patients were associated with changes which were probably anti-therapeutic for psychotic patients. Increased staff turnover was paralleled by changes which were probably unfavourable for both psychotic and nonpsychotic patients. An increased emphasis on interaction was paralleled by changes which were probably beneficial for nonpsychotic patients, but partly unfavourable for psychotic patients.

Adult↗
PubMed1986

Characteristics of a good ward atmosphere.

Thirty-five short term wards were evaluated with the WAS and a good milieu index. The results indicated that psychotic and non-psychotic patients need different types of atmosphere. Psychotic patients seem to benefit primarily from a milieu with a high level of Support, Practical orientation and Order and organization, and a low level of Anger and aggression, whereas non-psychotic patients seem to benefit mostly from a milieu with a high level of all subscales except for two: the level of Staff control ought to be low and the level of Anger and aggression ought probably to be intermediate.

Consumer Behavior↗
PubMedDate not supplied

Patterns of short-term course in patients treated in a day unit for personality disorders.

The objectives of the study were (1) to explore differences in the course for patients treated in a day unit specializing in personality disorders (PDs), and (2) to determine characteristics of patients with different courses and predictors of various courses. K-mean cluster analysis was applied to partition a sample of 128 patients, 101 with various PDs and 27 with axis I disorders only, into four groups representing different courses. The course was defined on the basis of global functioning (Health Sickness Rating Scale [HSRS]) at admission, discharge, and 3-years follow-up evaluation. The four courses were labeled good, fair, late improvement, and poor, demonstrating great variation in the short-term course among patients with PDs. Predictors were studied by means of polychotomous logistic regression using the patients with a fair course as the reference group. The dichotomy no PD/cluster C versus cluster A/B predicted a good versus a fair course. A poor work status the last year before admission and irregular discharge predicted a poor or late improvement course versus a fair course, also when controlling for PD clusters. None of the included variables discriminated between patients with a poor versus late improvement course.

Adult↗