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Biomedical subjects

S G Musselius

Publications and source records attributed to S G Musselius.

At least 19 recordsLinked to original sources
PubMed2005

[Endothelial dysfunction in severe forms of acute renal failure. New approaches to pathogenetic therapy].

AIM: To study endothelial function in different variants of acute renal failure (ARF) at various stages of the disease. MATERIAL AND METHODS: The study of 36 patients with severe ARF at the stages of oliguria and recovery of diuresis included a clinico-laboratory analysis of characteristics of ARF of various etiology and follow-up of plasmic concentrations of endothelin-1, thromboxan A2 and prostacyclin in different ARF variants at different ARF stages. RESULTS: The oliguric phase of severe ARF ran with significant elevation of the level of vasoconstrictive endothelial hormones (endothelin-1 and thromboxan A2 and a fall of a vasodilator prostacyclin. Recovery of diuresis normalized the above parameters. CONCLUSION: Mechanisms of ARF development involve endothelial dysfunction manifesting with alteration of vasoactive hormones synthesis with a dominant rise of a vasoconstrictive hormones concentration.

Acute Kidney Injury↗
PubMed1998

[Multiple organ insufficiency in destruction of soft tissues].

The authors report an analysis of 418 case records of patients with multiorganic insufficiency (MOI) due to extensive destruction of soft tissues as a result of prolonged, short-time or position compression, protracted arterial major blood-flow disturbances. Basic changes in the organism in endotoxemia and MOI are cuttined. Effectiveness of combined local and general treatment of patients in different periods of illness is considered. Unfavourable results obtained in usage of early stripe incisions in areas of soft tissues' damage made the authors to give up this type of surgical procedure. For prophylaxis and increase of effectiveness in treatment of MOI early revealing of soft tissues destruction is obligatory, especially in patients in critical conditions with concomitant injury and open fractures of bones. Effectiveness in treatment of MOI by extracorporeal methods of detoxication and correction of hemostasis, photo--and chemotherapy is shown. General mortality rate made up 9.1%.

Follow-Up Studies↗
PubMed1996

[New approaches to the pathogenetic therapy and prevention of acute kidney failure related to the use of x-ray contrast agents].

The authors analyze causes, mechanisms underlying acute renal failure (ARF) attributed to tests with application of radioopaque substances and results of ARF treatment in 12 ARF patients and on Wistar rats models. It is inferred that ARF is a frequent and severe complication of the above tests which may be treated successfully by early application of dialysis, filtration, sorption, plasmapheresis techniques. Disorders of calcium metabolism and their correction contribute to ARF onset. Radio-opaque substances have essential inhibiting action on nitrogen oxide synthesis in the kidneys of experimental animals.

Acute Kidney Injury↗
PubMedDate not supplied

[Use of xenogenic lyophilized hepatocytes in the treatment of acute and chronic liver diseases].

Therapeutic effect of lyophilized xenogenic hepatocytes was demonstrated on 30 dogs with acute hepatic failure and on white mice. The major biochemical values were corrected and the yeast fermentation test showed biological activity of isolated hepatocytes. Clinically, lyophilized hepatocytes were used in the treatment of patients with acute hepatic failure: orally in 47 and for extracorporeal dialysis in 8. The therapeutic effect of lyophilized hepatocytes is based on active detoxication and hemostasis correction. Clinical, laboratory, and instrumental studies showed improvement of the clinical status, decreased encephalopathy, and accelerated repair processes in the liver. Addition of lyophilized hepatocytes to combined therapy decreased the mortality by 2.5 times.

Administration, Oral↗