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Biomedical subjects

S G Musselius

Publications and source records attributed to S G Musselius.

29 records · Page 2Linked to original sources
PubMedDate not supplied

[Toxicity of mushrooms Paxillus involutus and Paxillus atrotomentosus].

Thirty-eight patients with mushroom (Paxillus involutus and Paxillus atrotomentosus) poisoning were treated. Slight poisoning (acute gastroenteritis) was diagnosed in 17 patients, medium-severe in 13, severe in 6, and extremely severe in 2 patients. Changes in the LPO-AOD system correlated with the severity of hepatorenal involvement. The treatment included hepatotropic therapy; patients with acute renal failure were treated by hemodialysis. Paxillus mushrooms induced functional evacuatory disorders in the small intestine. Eleven patients with adhesions in the abdominal cavity developed ileus. Two patients died: a man aged 26 years after eating fried (not boiled) mushrooms and a woman aged 76 years with ileus with symptoms of multiple organ dysfunction. The rest patients were discharged from hospital in satisfactory condition. Clinical course of poisoning with Paxillus mushrooms is discussed.

Adolescent↗
PubMedDate not supplied

[Formation of nitric oxide by peripheral blood leukocytes in the norm and in pathology].

The study was made of nitric oxide (NO) generation by leukocytes of peripheral blood from healthy subjects and patients with a compound trauma. How to isolate leukocytes from the whole blood is shown. Leukocyte isolation rate reached 98%. Generation of NO by leukocytes was made in the medium containing medium RPMI 1640 (free of phenol red), calf embryonic serum (5%), L-glutamine (2 mM), gentamycin (80 mcg/ml), penicillin (100 U/ml), streptomycin (100 mcg/ml). Incubation lasted for 15 h at 37 degrees in tissue culture plates with 24 cells 16 mm in diameter (Costor, USA). NO generation was defined in supernatants of cultivated leukocytes (5 x 10(6)) with Griss reagent in reaction with stable metabolite nitrite. NO content among the leukocytes from healthy subjects was 0.63 +/- 0.08 nmol, in trauma 1.10 +/- 0.08 nmol, relative production of NO by healthy subjects was 1.27 +/- 0.17 mumol/l, in trauma 2/21 +/- 0.18 mumol/l, absolute production was 0.99 +/- 0.15 mumol/l and 1.98 +/- 0.19 mumol/l, respectively. The findings point to an important role of nitric oxide generation by leukocytes in reaction with superoxide radical in production of peroxynitrite responsible for severity of endotoxicity.

APACHE↗
PubMedDate not supplied

[Informative value of the parameter "effective concentration of albumin" in diffuse peritonitis: data from a multi-center study].

The paper represents data on new potentialities in evaluating a severity of patients with total peritonitis (TP). They are based on the fluorescence analysis of the physical-and-chemical properties of blood albumin. The findings are a result of a multi-center research undertaken by clinics of Moscow and Moscow Region. The properties of albumin-molecule binding sites were investigated by the fluorescence test. The parameter, measured in the test, was named "effective albumin concentration". The study protocol comprised the data of clinical examinations, scales SAPS and MPI as well as laboratory findings and EAC. The subsequent analysis denoted that a combination of 2 parameters, i.e. EAC and serum urea concentration routinely measured, is highly informative in evaluating the TP severity and correlates well with the survival rate in the discussed pathology. The study results could be a basis for an early individual prognostication of TP course made on the 1st postoperative day.

Fluorescent Dyes↗
PubMedDate not supplied

[Pathology of crush syndrome].

Clinico-anatomical analysis of surgical material (32 cases) and 86 autopsy cases of myorenal syndrome (crush syndrome) is presented. Clinically in all cases there were symptoms of acute renal (hepatico-renal) failure which was a cause of death during the first 2 weeks. Septic complications were a cause of death at later periods. Grave alterations of traumatic, metabolic and septic origin were found in many organs in all cases. The sources of sepsis were decompressing longitudinal cuts and fasciotomies, shunts, lacerated wounds, catheters. Combined local treatment of wounds with sorbents, antibiotics, proteolytic enzymes, quantum therapy facilitated the destruction of bacteria and loss of their activity, wound purification and thus allowed coping with septic complications.

Acute Kidney Injury↗
PubMedDate not supplied

[Ways of increasing effectiveness of emergency detoxication in acute exo- and endotoxicoses].

The experience in complex detoxication in acute poisonings and endotoxemias (sepsis, burn-induced toxemia, alcohol and narcotic abstinence, acute hepatorenal failure) has been analysed. The efficacy of various detoxication techniques have been assessed. The techniques compared were sorption dialysis and pharmacological ones, as well as physiohemotherapy as part of magnetic and UV hemotherapy, enhancing the detoxicating process and facilitating adequate correction of homeostasis parameters at all stages of toxemia management. It has been found that hemosorption has the greatest effect on the kinetics of toxic compounds, while physiohemotherapy has the greatest effect on homeostasis parameters. Rational approach to complex detoxication leads to the improvement in treatment results.

Acute Disease↗
PubMedDate not supplied

[Acute kidney failure from the nephrotoxic action of x-ray contrast media].

Causes and mechanisms involved in the onset of severe forms of acute renal insufficiency induced by highly osmotic ionic x-ray contrast media have been analyzed for 9 patients suffering from renal and other diseases. Risk factors and factors of principal importance in promotion of nephrotoxicity of contrast media are the following: preexisting renal dysfunction, cardiovascular insufficiency, hypovolemia, calcium and sodium dysbolism. Approaches to prevention of contrast media nephrotoxicity with employment of forced diuresis, vasodilators, calcium channels blockers are under consideration.

Acute Kidney Injury↗