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S Graham

Publications and source records attributed to S Graham.

At least 271 records · Page 15Linked to original sources
PubMed1980

Diet and cancer.

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Colonic Neoplasms↗
PubMed1980

Spouse-subject interviews and the reliability of diet studies.

Recently published data suggest relationships between ingestion of a number of food items and risk of cancer of the stomach, bowel and mouth. This engenders concern over the accuracy of such data. To study this, dietary interviews of 158 males in the Western New York Study of Cancer Epidemiology are compared to their spouses' estimates of the husband's dietary histories as taken in separate interviews. Respondents were asked to estimate the frequency with which the males consumed each of several foods. For analysis, the frequency estimates were assembled into categories similar to those used in recent epidemiologic analysis: 5-7 times per week, 1-4 times per week, 1-3 times per month and less than once per month. Generally, 60-80% of respondents pairs agree exactly on the frequency of consumption for individual food items. Over 90% of spouse and respondent food frequency estimates are within one frequency category of each other. Radical disagreements between spouses are rare; generally, in less than 2% of spouse pairs does one member estimate the maximum frequency category, and the other minimum frequency category. The authors suggest therefore that, although diet histories are not precisely replicable, they must be adequate to reveal gross differences between cases and controls.

Adult↗
PubMed1980

Creative capabilities of learning-disabled and normal students.

The Torrance Tests of Creative Thinking (Figural Form A) and Sounds and Images were administered to 26 learning-disabled and 30 average students in Grades 3, 4, and 5. Significant differences between the two groups were noted on all measures except fluency. Although learning-disabled students produced an equivalent number of relevant creative responses in comparison to their average peers, they were less able to generate new ideas and change their initial approach.

Child↗
PubMed1979

Genital cancer in wives of penile cancer patients.

We identified the wives or ex-wives of 227 males of the 256 reported with cancer of the penis to the New York State Cancer Registry from Upstate New York from 1960-64. Utilizing the Registry, death certificates, hospital and physician records, we ascertained those wives who developed cancer at any site from 1951-1975. We generated expected numbers of cases of cancer at each site by applying the age specific incidence rates experienced by women of a specific age in a specific year designated by the age of the wife of the index case in each year, estimating withdrawals from age-specific death rates. Thus, our expected numbers are based on the experience of the women in Upstate New York with traits like those of spouses of the men in the same population with cancer of the penis. We found significantly more cases of cancer of the cervix than expected. This was not true for other sites of cancer.

Adult↗
PubMed1979

Restriction-fragment map of the temperate Bacillus subtilis bacteriophage SPO2.

The endonucleases BglI, BglII, EcoRI, SalI, SmaI, and XbaI were used to fragment the phage SPO2 DNA. Electrophoretic analysis using ethidiumbromide agarose gels showed the phage to have nine BglI sites, one BglII site, four EcoRI sites, one SalI site, one SmaI site, and six XbaI sites. Using partial digestions, multiple endonuclease digestion, and autoradiography the fragments were sized and ordered into a circular map of 23 Md. Such an analysis locates the endonuclease sites, indicates which endonucleases are potentially useful in cloning with SPO2, and allows insertions and/or deletions in the SPO2 DNA to be characterized.

Bacillus subtilis↗
PubMed1979

Isolation and characterization of viable deletion mutants of Bacillus subtilis bacteriophage SPO2.

Spontaneous deletion mutants of the bacteriophage SPO2, which are viable and retain their temperate character, were isolated using a heat-EDTA enrichment step. They were identified by endonuclease digestion and agarose-gel electrophoresis of phage DNA. Two of the nine mutants were characterized in detail. Both mutants have a 2.3 Md deletion removing the single BglII site and two of the XbaI fragments. The deletion extends 1.0 Md to one side of the former BglII site and 1.3 Md on the other side. This region of the SPO2 genome is non-essential for either lysogeny or viable phage production and thus is a suitable region for the insertion of exogenous DNA fragments.

Bacillus subtilis↗
PubMed1979

Dietary risk factors in human bladder cancer.

Retrospective data on dietary habits, employment history and tobacco use were obtained from 569 bladder cancer patients and 1025 age-matched controls admitted to Roswell Park Memorial Institute. Sex-adjusted relative risks revealed increases in risk for lower levels of an index of vitamin A intake. A similar pattern of risk elevation was associated with infrequent milk and carrot intake. Some elevation of risk was found for heavy coffee drinking but the apparent protective effect for milk consumption was not found to be a spurious result of lower coffee intake. Neither was the role of vitamin A explained by its relationship with smoking or employment in high risk occupations. Some association of bladder cancer with infrequent consumption of cruciferous vegetables was also observed. The findings of this investigation are consistent with tumor inhibition by retinoids in animal studies and the low risk associated with vitamin A in epidemiologic studies of lung cancer.

Animals↗
PubMed1979

Vitamin A and lung cancer.

Retrospective dietary and smoking data were gathered by interview of 292 white male patients with lung cancer and 801 control patients with nonrespiratory, nonneoplastic diseases at Roswell Park Memorial Institute, Buffalo, New York. A computed index of vitamin A intake was used to differentiate lung cancer patients from controls. Lung cancer patients had lower values than did controls. The reduced relative risk (RR) of lung cancer associated with vitamin A was most evident among men who smoked heavily. For them, a dose-response relationship increasing to an RR of 2.4 for low values of the index was observed. Frequency of daily milk drinking was lower among patients with lung cancer. Lower RR was found among the men who smoked heavily and frequently consumed carrots. These findings are consistent with evidence from animal studies on inhibition of tumor incidence by retinoids and with previous findings in prospective and retrospective epidemiologic studies.

Diet↗
PubMed1979

Epidemiology of cancer of the cervix in Buffalo, New York.

An investigation was done to determine whether patients with cancer of the cervix from Buffalo and Kenmore, New York, differed from a random sample of women from the same communities on a variety of parameters associated with marital and reproductive history. A comparison of the 285 patients and 1,620 controls showed that patients were more likely than controls to have been black and non-Jewish, to have married young, to have had more than one husband, and to have been young at the time of their first pregnancy. In addition, they were more likely to have frequently used the vaginal douche and to have used it over many years. As frequency of douche increased, so did risk of cervix cancer.

Adult↗
PubMed1979

Intra-individual variation in commonly analyzed serum constituents.

Concentrations of 27 commonly estimated serum constituents were measured in blood sampled from 20 apparently healthy volunteers at 0830, 1230, and 1630 hours on each of four days, at weekly intervals. Time-dependent statistically significant (p less than or equal to 0.01) variation was observed in 12 of the constituents. The 15 constituents that showed no statistically significant diurnal variation included the immunoglobulins, other specific proteins, enzymes, cholesterol, calcium, copper, and magnesium. On the different days of the study consistent temporal patterns were observed in urea, creatinine, phosphate, zinc, bilirubin, triglyceride, total protein, and albumin. The magnitude of variation was particularly great in potassium, iron, zinc, and bilirubin. In general, day-to-day changes in concentration exceeded within-day changes, except for potassium, phosphate, and zinc, for which greater changes could be observed within-day than from one day to another at the same time.

Alanine Transaminase↗
PubMed1978

Diet in the epidemiology of cancer of the colon and rectum.

We examined the diets as reported in interviews of 256 white male patients with cancer of the colon and of 330 white male patients with cancer of the rectum. Controls were 783 patients with nonneoplastic, nondigestive system diseases distributed by age similarly to the colon cancer patients and 628 patients with nonneoplastic, nondigestive diseases distributed by age like those with cancer of the rectum. We found no increase in risk for cancer of the colon or rectum regardless of the amounts of beef or other meats ingested. However, we found an increase in risk of colon cancer with decreases in the frequency with which vegetables were eaten. A study of 214 females with cancer of the colon and 182 females with cancer of the rectum yielded similar results. The decrease in risk we found associated with frequent ingestion of vegetables, and especially cabbage, Brussels sprouts, and broccoli, is consistent with the decreased numbers of tumors observed in animals challenged with carcinogens and fed compounds found in these same vegetables.

Animals↗