[Follow-up of 53 patients with ovarian carcinoma].
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Biomedical subjects
Publications and source records attributed to S Grillo.
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After reviewing the more recent acquisitions on the physiology and pathophysiology of gastrin, the authors concentrate on situations of hypergastrinemia, which they divide into a hyperhydrochloric and a hypohydrochloric variety. Among the former, which they subdivide into preoperative and postoperative, the authors discuss problems of differential diagnosis versus peptic ulcers in patients so afflicted. To that end they propose diagnostic policies comprising among other instrumental and laboratory tests the study of gastric secretion, blood gastrin levels in basal conditions and after stimulation by a protein meal, BBS, secretin, and calcium. From analysis of the results of such tests they were able to find a precise nosographic placement for postoperative hypergastrinemia, and from there they arrived at surgical programs aiming to correct postoperative peptic ulcers on the basis of their etiology and pathogenesis.
In view of the results obtained in 32 cases of primary closure of the perineum after amputation of the rectum for cancer, the authors believe that this policy is best after removal of the malignancy by the abdominoperineal approach. Unquestionable advantages are shortening of the patient's hospital stay and a more rapid recovery; the possible disadvantages are relatively rare, from an uncommonly severe dysmetabolic situation to local disorders such as poor hemostasis, contamination of the operation site, inadequate preoperative antibacterial protection, or an unusually large tumor.
The authors describe one case of massive penetration of barium and air through the splenic vein into the portal system during administration of a radiopaque enema to a woman suffering from hemorrhagic proctitis in the florid phase. They provide a detailed description of this rare clinical case and discuss the possible etiology and pathophysiology of the observed event.
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The Authors have studied th haemodynamic response of ten normal subjects to the intravenous administration of 160 MRC.U. of Calcitonin in 60 min, by serial measurement of the systolic time intervals. The analysis of results pointed out a minor inotropic effect starting from the 10th minute from the beginning of the infusion. Little but significant decrements (P less than 0.01) in the duration of the pre-ejection phase of the isovolumetric contraction time, as well as a significant increase (P less than 0.01) in the LVET/PEP ratio, have been noted. A negative chronotropic effect (P less than 0.05) has been noted starting from the 30th minute. The mechanism by which Calcitonin can modify the myocardial inotropism in the normal subject is till now unknown, and it could be related to the interference of this hormore on the endocellular movements of Calcium, and on the cellular levels of cyclic AMP.
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The control during the planning of a factory is a sort of prevention. For instance, we suggested industrial hygiene standards for a new chemical plant, which have been into account. According to our suggestions they set up a closed factory process, a dust and fumes filtering plant and the water recycle. After some controls outside the factory, lead and dust concentrations were below the maximum allowed levels (30 and 5 mg/Nmc).
The Author presents a pliers with millimetres as notch, fitted to take, measure and fix the brackets in only one time. This method permits to reduce the positional errors.
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