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S Guibaud

Publications and source records attributed to S Guibaud.

67 records · Page 4Linked to original sources
PubMedDate not supplied

[Iliac crest bone CO2 and CO2/Ca ratio in man during respiratory failure (author's transl)].

The bone is often considered as a slow exchanger and bone sampling from the iliac crest, by needle-biopsy, is a commonly used and atraumatic technique; therefore the significance of the evolution of CO2 stores has been investigated in iliac crest in respiratory failure. Samples are taken before ventilation and on the first, second, and in some cases third days after ventilation. The results show that ageing is to be considered, since the CO2/Ca ratio varies according to the age group (0.84 at 30 years and 1.35 at 60 years). Patients with respiratory failure may be distributed into two main categories: hypoxic patients without hypercapnia, and patients with predominant hypercapnia. Hypercapnic patients may be differentiated from the hypoxic ones, both before assisted ventilation and on account of the dynamic phenomena that come into play during respiratory support in this group of patients. If the equilibrium state (at least five days with rigorously steady gazometry), before assisted ventilation, remains unknown, it is not possible to distribute the patients in one of these two groups. The results' significance is discussed, as well as the possible therapeutic applications.

Bone and Bones↗
PubMedDate not supplied

[The antenatal diagnosis before 20 weeks of an omphalocoele and a failure of development of the abdominal wall (author's transl)].

We report 2 cases of malformations occuring in the region of the umbilicus which were diagnosed by amniocenteses before the 20th week of pregnancy (with levels of alphafetoprotein) and echography. Failure of development of the abdominal wall was only diagnosed for certain after the therapeutic abortion had been carried out. The omphalocoele was diagnosed for certain by echography at the 19th week after anencephaly and spina bifida had been eliminated in spite of an abnormally high rise in the level of amniotic fluid alphafetoprotein (100.000 microgram/l). We have not found any similar cases in the literature at this gestational age. These observations prove the value of combining the estimation of alphafetoprotein level in the amniotic fluid when making antenatal diagnoses because of the age of the mother (after the age of 38), with echography specially directed to searching for such apparent morphological abnormalities.

Abdominal Muscles↗
PubMedDate not supplied

[Unusual behavior of serum markers in risk evaluation for trisomy 21].

Screening of Down syndrome using serum markers is based on statistic risk determination calculated from the results of markers. An increased risk of fetal Down syndrome is associated with high hCG levels and low AFP levels in maternal serum. In the daily practice, the use of these two markers also leads to observation of different analytical patterns. We reviewed these patterns according to published data and our own experience. Some patterns are well documented (neural tube defects or trisomy 18) some of them remain unexplored. Numerous difficulties are encountered in the clinical use of these markers patterns: lack of consensus for their analytical definition, problems in interpretation, lack of regular dispositions.

Biomarkers↗