PubMed Health⌕ Search

Biomedical subjects

S H Zaidi

Publications and source records attributed to S H Zaidi.

At least 55 records · Page 3Linked to original sources
PubMed1978

Pulmonary response to kaolin, mica and talc in mice.

Following intratracheal inoculation the pulmonary fibrogenic response of kaolin, mica and talc was investigated in mice over a period of 210 days. All the three dusts incited acute inflammatory reaction at early periods but with mica dust the acute reaction persisted longer. Subsequently there was gradual increase in the fibroblastic activity in the focal areas and mica produced, in addition, many cholesterol cleft-like structures together with marked fibroblastic activity and lymphocytic infiltration. Towards the termination of experiment at 210 days the fibrosis, in general, remained restricted to grade II with kaolin and mica while talc produced thickened interalveolar septa. The transport of dust from lungs to lymph nodes occurred earlier with mica than with kaolin or talc dust accompanied with little fibrotic reaction. The significance of the findings has been discussed.

Animals↗
PubMed1978

Formation of asbestos bodies under the influence of parenteral iron overload.

The effect of parenteral administration of iron (dextran) on the number of asbestos fibers in the lungs, formation of asbestos bodies and the development of interstitial fibrosis was studied in guinea pigs exposed intratracheally to anthophyllite dust. The treatment did not accelerate, either qualitatively or quantitatively, the formation of asbestos bodies or retard the development of interstitial fibrosis. The number of naked asbestos fibers was also similar in anthophyllite-inoculated animals to those similarly inoculated, but having had, additionally, a previous saturation with iron.

Animals↗
PubMed1977

Toxicological studies on hydrocarbons--Iomex.

Hematological changes and concurrent enzymatic activities in various tissues were determined in rats injected parentally with Iomex, a petroleum derivate and proposed weedicide. Among the hematological parameters studied only the differential leucocytic count showed significant alterations. This was indicated by a significant decrease in the number of lymphocytes and an increase in those of neutrophils. Significant differences were not observed in the levels of acid phosphatase, glutamic oxaloacetic, and glutamic pyruvate transaminase activities in brain and liver of the experimental group of animals.

Acid Phosphatase↗
PubMed1977

Early biochemical response of pulmonary tissue to manganese dioxide.

The biochemical response of pulmonary tissue to MnO2 dust burden of 30 days duration was studied in rats. The activities of enzymes from isolated fractions of rat lungs were not significantly altered, even though manganese content was increased significantly in tissues remote from lungs, indicating translocation of the dust from its intrapulmonary location.

Animals↗
PubMed1977

Effect of talc injected intravenously in guinea pigs.

The pulmonary angiothrombotic lesions in narcotic addicts attributed to the talc present in drug tablets were studied experimentally in guinea pigs following repeated intravenous administration of a suspension of talc dust (75 mg per animal). In early periods there was a moderate localization of talc particles in the alveolar capillaries of lung, liver and abdominal lymph nodes. The vascular injury in the pulmonary tissue was in the form of mild proliferation of the endothelial cells. In addition, many nodular collections comprising macrophages and lymphocytes developed around such vascular structures. At later periods (150 days) the only significant reaction obtained was moderate thickening of interalveolar septa and the lesions were in no way comparable to the human reports. The significance of these findings has been discussed.

Animals↗
PubMed1977

Dissolution of silicic acid from dusts of kaolin, mica and talc and its relation to their hemolytic activity. -- an in vitro study.

Hemolysis induced by native kaolin dust was found to run parallel to the amount of silicic acid dissolved from it. Native mica and talc dusts were hemolytic only to a small extent and the silicic acid dissolution from these dusts was also smaller in comparison to that of native kaolin. The proportionality between hemolysis and the amount of dissolved silicic acid was not consistently observed in the case of acid, alkali and water treated kaolin, mica and talc dusts.

Animals↗
PubMed1977

Habits and dietary pattern of cases of carcinoma of the oral cavity and oropharynx.

In 1192 biopsy proven cases of carcinoma of the oral cavity and oropharynx information was collected on the use of various chewing, smoking, and eating habits. The quantity used and the duration of use were also recorded. Information was also collected on the frequency of use of cereals, dairy products, meat, fish, fruits and vegetables. The information from carcinoma cases was compared with that from apparently healthy individuals.

Alcohol Drinking↗
PubMed1976

Experimental manganese lymphadenopathy in guinea pigs.

Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did not provoke any significant reaction at early periods. However, at later periods the nodes exhibited a significant increase in the density of dust particles and the reaction consisted of phagocytosis, degeneration of dust laden macrophages, slight proliferation of fibroblasts, together with some reticulinosis corresponding to deposits of dust particles. The significance of these findings have been discussed from the chronic toxicity viewpoint.

Animals↗