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Biomedical subjects

S Herman

Publications and source records attributed to S Herman.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Spondylolisthesis with severe displacement in children and adolescents Results of 12 cases of posterior reduction fixation].

The aim of this study was the analysis of 12 cases showing a L5-S1 spondylolisthesis of a shift superior to 50%. The surgery performed on those 12 children and teenagers was Roy Camille's technical procedure that is reduction and fixation with posterior plates and postero-lateral grafting The criteria of the study and technique used are first recalled. The result's analysis show the quality of the reduction and the restoration of the lumbo-pelvic statics. The postero-lateral arthrodesis appears to the authors as sufficient to guarantee the result's stability. In cases of associated radicular impairment, great care must be taken as far as the reduction is concerned. The root must be controlled during the surgical procedure especially if there is a real sciatic before surgery. The technic appears to the authors as the best among all those they may have used for the treatment of the spondylolisthesis with an important shift, apart from the spondyloptosis. Internal fixation devices of a smaller size would be necessary for a small child.

Adolescent↗
PubMed1987

Properties of N-acetylglucosamine 1-phosphotransferase from human lymphoblasts.

Human lymphoblast and fibroblast cell lines from a patient with I-cell disease and normal individuals were characterized with respect to certain properties of UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine phosphotransferase. The enzyme isolated from normal lymphoblast and fibroblast cell lines expressed similar kinetic properties, substrate specificities and subcellular localizations. Coincident with the severe reduction of N-acetylglucosamine phosphotransferase activity in both I-cell fibroblast and lymphoblast cell lines, there was an increased secretion of several lysosomal enzymes compared to normal controls. Subsequent examination of N-acetyl-beta-D-hexosaminidase secreted by the I-cell lymphoblasts demonstrated a significant increase in adsorption of the I-cell enzyme to Ricinus communis agglutinin, a galactose-specific lectin. However, the I-cell lymphoblasts did not exhibit the significant decrease in intracellular lysosomal activities seen in I-cell fibroblasts. Our results suggest that lymphoblasts not only represent an excellent source for the purification of N-acetylglucosamine phosphotransferase, but in addition, represent a unique system for studying alternate mechanisms involved in the targeting of lysosomal enzymes.

Cell Line↗
PubMed1987

Long-term efficacy and safety of beta-adrenergic receptor antagonists for supraventricular tachycardia.

The efficacy and safety of nadolol and atenolol, 2 new long-acting beta-adrenergic receptor antagonists, were evaluated in patients with recurrent supraventricular tachycardia (SVT). Intravenous and oral drug therapy was administered to patients with atrioventricular reentrant tachycardia and atrioventricular nodal reentrant tachycardia. Efficacy was judged on a short-term basis by programmed electrical stimulation and on a long-term basis by clinical parameters and serial ambulatory electrocardiographic recordings during long-term follow-up. In addition, the usefulness of programmed electrical stimulation to predict long-term efficacy was evaluated. Intravenous nadolol prevented induction of SVT in 6 of 8 (75%) patients with atrioventricular nodal reentrant tachycardia, and oral nadolol prevented induction of SVT in 5 of 6 (83%) responders to intravenous nadolol. No episodes of sustained SVT recurred in these 5 patients during follow-up. Intravenous nadolol also prevented induction of SVT in 2 of 17 (11%) patients with atrioventricular reentrant tachycardia. Both patients remained non-inducible during treatment with oral nadolol, and neither experienced recurrence of SVT during follow-up. Intravenous atenolol prevented induction of SVT in 5 of 6 (83%) patients with atrioventricular nodal reentrant tachycardia. Oral atenolol prevented induction of atrioventricular nodal reentrant tachycardia in 4 of 5 (80%) patients responding to intravenous atenolol, and none of these 4 patients experienced a clinical recurrence. Intravenous atenolol prevented induction of SVT in 1 of 4 (25%) patients with atrioventricular reentrant tachycardia. Oral atenolol prevented induction of SVT in this patient and the arrhythmia has not recurred during follow-up. During follow-up (1 to 37 months), drug tolerance and compliance have been excellent with a low incidence of adverse reactions (11%).(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1986

Magnetic resonance imaging of the mediastinum.

Seven normal volunteers and 69 patients with known disease in either the mediastinum or hila or both were imaged using a prototype magnetic resonance imager operating at 0.15T. Normal mediastinal and hilar structures were readily identified and mediastinal diseases were well demonstrated by magnetic resonance imaging (MRI). The value of MRI lies in the morphological demonstration of the presence and extent of disease.

Adult↗
PubMed1975

Intestinal biopsy in the diagnosis of cow's milk protein intolerance without acute symptoms.

4 infants, suspected of cow's milk protein intolerance, were placed on an elimination diet and then challenged with cow's milk. None reacted clinically, yet in 2 of the 4 patients jejunal biopsy revealed clear histological, ultrastructural, and immunological changes. It is suggested that these changes are the objective criteria on which the diagnosis of cow's milk intolerance should be based, and that the clinical evidence derived from milk challenge after an elimination diet may be unreliable.

Biopsy↗