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Biomedical subjects

S Inutsuka

Publications and source records attributed to S Inutsuka.

At least 55 records · Page 3Linked to original sources
PubMed1988

Serum testosterone level in the peripheral vein and the perigastric draining vein of patients with gastric carcinoma.

The serum testosterone level (STL) was determined in 181 patients with gastric carcinoma, 128 male and 53 female, and in 98 patients with benign diseases, 67 male and 31 female. As in our previous report, the preoperative STL of the cancer group was significantly lower than that of the control group, in both male and female patients (P less than 0.001). In the present study, the STL of the perigastric vein draining the stomach was determined and compared with the STL of the blood obtained at the same time from the peripheral vein during the operation. It was found that, in the male patients, the STL of the blood obtained from the perigastric vein draining a stomach with carcinoma was significantly lower than that of the peripheral vein in the same patient (P less than 0.001); however, there was no difference between these STL in the control group. On the contrary, in the female patients during operation, no such phenomenon was confirmed. Analysis classifying the patients by histological type revealed almost the same results for all patients as those shown for the cancer group, i.e. there was a proven significant difference in male patients and no significant difference in female patients. It was therefore considered that the mechanism of decrease in preoperative peripheral STL was not always the same in male patients as in female patients, although the STL decrease was observed to be similar in both sexes before surgery.

Adenocarcinoma↗
PubMed1988

[A minute, solitary carcinoid of the stomach with a lymph node metastasis--a case report].

The patient, a 25-year-old woman, complained of epigastralgia. Her physical examination and routine laboratory data were unremarkable, though an upper G-I series and a gastro-endoscopy demonstrated a small sessile polypoid lesion at the posterior wall of the gastric body. An endoscopic biopsy specimen taken from the polyp revealed a typical carcinoid tumor. The patient underwent a wedge resection of the stomach and a sampling was taken of the regional lymph node around the left gastric vessels. Histologically, although the carcinoid tumor was 5 mm in diameter and limited to within the submucosal layer, it showed lymphatic and venous invasion into the submucosal layer and had metastasized to one of the regional lymph nodes around the left gastric vessels. Therefore, a total gastrectomy with an extended lymph node dissection was performed and no other metastatic lesion was uncovered. Of the reported cases with a gastric carcinoid thus far, none with a tumor size of less than 5 mm has evidenced metastasis. This case suggests that even cases of a minute gastric carcinoid should be treated by radical gastrectomy and extended lymph node dissection.

Adult↗
PubMed1987

[Effect of splenectomy in gastric carcinoma surgery on cell-mediated immunity; evaluation with alteration of peripheral blood lymphocyte subsets].

Peripheral blood lymphocyte subsets were studied in 70 patients who underwent gastrectomy for gastric carcinoma. Lymphocyte subsets were analysed before and after gastrectomy by use of monoclonal antibody for cell membrane markers. There were significant differences in the gastrectomized patients with splenectomy compared to the patients without splenectomy in postoperative changes of lymphocyte subsets as follows. Decrease of OKT4 and increase of OKT8. Temporary decrease of B-1. Continuous increase of Leu-7. These results suggest that gastrectomized patients with splenectomy show a decrease in helper activity, an increase of suppressor activity of T lymphocytes and a compensatory increase of population of natural killer cells in association with suppression of natural killer activity.

Female↗
PubMed1987

[Effectiveness of multidisciplinary treatment combined with immunotherapy in esophageal cancer--analysis of 287 cases of carcinoma of the thoracic part of the esophagus in Kyushu and Yamaguchi districts].

The effectiveness of surgical adjuvant immunochemotherapy was studied on 287 patients with thoracic esophageal cancer in the Kyushu and Yamaguchi districts. Pre- and postoperative subcutaneous administrations of BCG, 10 mg once a week and an oral administration of PSK, 3 g a day, for as long as possible after surgery were instituted. The control group was designated as the one which neither PSK nor BCG was given. Most patients received chemotherapy and/or radiotherapy. Significant elongation of survival time was observed in immunotherapy patients with stage III and in those with non-curative resection, both having no lymph node metastasis.

Adult↗
PubMed1986

Serum testosterone level of patients with gastric carcinoma before and after gastrectomy.

The serum testosterone level (STL) was determined in 84 male and 32 female patients with gastric carcinoma and in 58 male and 20 female patients with benign diseases as a control group. The STL of the male patients with carcinoma was lower (446 +/- 149 ng/dl) than that of the male control group (532 +/- 132 ng/dl) (P less than 0.001). Even 17 male patients of the early carcinoma showed lower STL (440 +/- 117 ng/dl) than the normal group (P less than 0.001). In the female patients, it was also lower (31.6 +/- 16.0 ng/dl) than in the control group (46.3 +/- 15.3 ng/dl) (P less than 0.005). The postoperative STL of the cases surviving the gastrectomy was higher than the preoperative data in 32 male patients (P less than 0.005) as well as in 12 female patients (0.025 greater than P greater than 0.01), whereas it obviously decreased in the patients who died of recurrence. Therefore, it appears that gastric carcinoma decreases the STL by some mechanism.

Carcinoma↗
PubMed1982

Intra-arterial dye method with vasomotors (PIAD method) applied for the endoscopic diagnosis of gastric cancer and the side effects of indigo carmine.

Forty patients with stomach cancer, including 25 patients with early carcinoma, were examined endoscopically during the perfusion of Indigo carmine dye into the celiac artery in association with vasomotors. In all of these patients the diagnosis had been established definitively by aimed biopsies before the procedure. This new endoscopic examination is useful not only to determine the margin of the superficial carcinoma, even when it is covered with regenerative epithelium, but also to detect small lesion less than 10 mm in diameter. Liver function tests in 31 patients who underwent the examination have negated the possibility of acute toxicity of the dye. But this new method should be employed with caution in hypertensive or high-risk patients.

Adenocarcinoma↗
PubMed1982

Heterotopic gastric mucosa in the duodenum - reaction to Congo red under fiberscopic observation.

A 64-year-old woman had gastric heterotopic of the duodenal bulb without any specific complaints. The lesion with irregular excrescence was diagnosed by means of target biopsies through endoscopy, and 3 years later, no noteworthy changes were observed in the endoscopic findings of the lesion, and it was also proved by an endoscopic Congo red test that the excrescence had a function of acid output. This is the second report of congenital heterotopic gastric mucosa of the duodenum which was confirmed not only by histological, but also functional examination.

Child↗
PubMed1980

Onlay fundic patch method applied in spontaneous rupture of the esophagus: a case report.

A successful attempt using the onlay fundic patch method for treatment of spontaneous rupture of the esophagus (SRE) was reported. A 38-year old male presented with left chest pain and a preoperative diagnosis of SRE was made. Surgery was performed 16 hours after the onset of symptoms and a 3 cm esophageal tear just above the level of the diaphragmatic hiatus was noted. The esophageal tear was repaired by the onlay fundic patch method through left thoracotomy and the postoperative course was uneventful and recovery was complete. A search of the literature has yielded only one case of SRE that was improved with onlay fundic patch by Thal and Hatafuku (1964) and this method is useful for the immediate and late repair of rupture of the esophagus.

Adult↗
PubMed1980

A new trial in endoscopic diagnosis for stomach cancer:intra-arterial dye (IAD) method.

Forty gastric cancers were examined by endoscopy before and after the injection of Evans blue or indigo carmine dye into the celiac artery. Seventeen of these lesions were also examined after injection of vasomotor drugs. The authors conclude that these techniques permitted more precise endoscopic deliniation of the size and extent of cancerous lesions, particularly those otherwise obscured by overlying, intact epithelium.

Adenocarcinoma↗
PubMed1979

Mechanical suture methods in esophago-gastrointestinal anastomosis.

Mechanical suturing procedures have been performed in 10 patients for total gastrectomy, 6 for proximal partial gastrectomy and 7 for esophageal transection. The instrument (SPTU all-round type made in Russia) proved simple to use and produced reliable good quality closures without any other inforcement. There was one minor suture leak in 10 patients with intramediastinal esophagojejunostomy and in 6 with proximal partial gastrectomy respectively, but neither leak nor other problem has been arisen in esophageal transection for varices. It is believed that this staple suturing methods used SPTU all-round type apparatus are safe from anastomotic failure and useful for secure intramediastinal anastomosis in high level, and they represent a significant advance in the technique of thoraco-abdominal surgery.

Adult↗
PubMed1979

Fatal interstitial pneumonitis induced by low dosage of bleomycin in an esophageal cancer patient.

One-shot intratumor injection of 60 mg oil-bleomycin prior to subtotal esophagectomy induced fatal, acute interstitial pneumonitis in a 53 year-old esophageal circinoma patient. The progression of bleomycin-induced pneumonitis was rapid and the patient succumbed to respiratory insufficiency 41 days after surgery (58 days after bleomycin administration). Autopsy revealed bilaterally increased lung weight and the organ was of rubbery consistency and anthracotic. Histology showed advanced interstitial fibrosis, numerous lymphocytes in alveolar septi and fibrinous exudate, macrophages and desquamative cells within the alveolar spaces. In the present case, pneumonitis was due not to patient age or dosage level of bleomycin, but rather to the administration method.

Bleomycin↗
PubMed1978

Plasma copper and zinc levels in patients with malignant tumors of digestive organs: clinical evaluation of the C1/Zn ratio.

The plasma copper level (PCL) and plasma zinc level (PZL) were determined in 126 patients: 54 had carcinomas of which 40 were carcinomas of the digestive organs, 37 had benign lesions, and 35 were without disease. The PCL increased and the PZL decreased significantly in the group with carcinoma of the digestive organs. The CuHZn ratio was not only significantly higher than in the normal group, but also was high in cases with advanced carcinoma especially when liver metastasis was present. Therefore, the Cu/Zn ratio may be valuable in estimating the extent of the carcinoma as well as in determining the prognosis of the cancer patients.

Aged↗
PubMed1976

Clinical characteristics of the carcinoma of the stomach and its localization.

The result of follow-up study and the localization of gastric carcinoma subjected to the operation at the Second Department of Surgery, Faculty of Medicine, Kyushu University during 7 year period from 1963 to 1969 form the basis of the present communication. The curative resectability was 70.3 per cent in the carcinoma of the distal third of the stomach (A), 82.9 per cent in that of the middle third (M) and 55.3 in that of the proximal third (C); the 5-year survival rate was 48.6 per cent in the cancer of A, 81.1 per cent in that of M and 49.1 per cent in that of C respectively. In the carcinoma of A incidence of high grade penetrative invasion into the gastric wall as well as metastatic involvment was high. It is noteworthy that the tendency of the metastasis was found even in those with low grade penetration. In the carcinoma of M the incidence of high grade penetration as well as lymphatic metastasis was relatively low. The hepatic metastasis and peritoneal dissemination was also not frequent. In the carcinoma of C the incidence of high grade penetration was very high and the lymphatic metastasis was frequently observed in those with high grade penetration. Biological characteristics of the carcinoma of the stomach in each location and their therapeutic significance are discussed.

Follow-Up Studies↗