Biomedical subjects

S J Urbanski

Publications and source records attributed to S J Urbanski.

61 records · Page 4Linked to original sources

PubMed1984

Invasive aspergillosis in a "healthy" patient.

A case of invasive aspergillosis complicated by the formation of an aspergilloma is described. The patient, a 48-year-old man, was apparently healthy except for mild alcoholic steatosis of the liver. A review of the literature revealed that 5 of the 14 previously reported cases of invasive aspergillosis in seemingly immunocompetent hosts were associated with liver disease. Immunologic investigation in this case revealed transient cutaneous anergy during the acute illness and normal lymphocyte function. Assessment of polymorphonuclear leukocyte function, however, showed abnormalities of phagocytosis as well as impairment of intracellular bactericidal activity. These abnormalities may have contributed to a relative immunodeficiency. Impairment of immune function may play a role in the pathogenesis of invasive aspergillosis in some apparently healthy patients.

Acquired Immunodeficiency Syndrome↗

PubMed1984

Organ specificity in the microsomal activation and toxicity of N-nitrosomethylbenzylamine in various species.

The microsomal metabolism of the rat esophageal carcinogen N-nitrosomethylbenzylamine (NMBZA) at the methylene carbon atom to yield benzaldehyde was studied in various organs of a number of species to determine the role of metabolic activation in the carcinogenicity or toxicity of the nitrosamine. In the Sprague-Dawley rat, NMBZA was metabolized by microsomes from liver, lung, and esophageal mucosa. In the F344 rat and rabbit, metabolic activity was present in both liver and esophageal mucosa, the only tissues studied in these species. In contrast, in the Syrian hamster and BALB/cByJ mouse, NMBZA debenzylation was undetectable in the esophagus but occurred at relatively high rates in liver, lung, and kidney. The forestomach mucosa exhibited undetectable levels of activity in the Sprague-Dawley rat and BALB/cByJ mouse, although in the hamster, it was present at a very low level. Administration of a dose of NMBZA acutely toxic to the rat (18 mg/kg i.p.) resulted in significant cellular damage only to the rat esophageal mucosa, no other tissues examined in the rat, hamster, or mouse being affected. These observations, together with the available data on carcinogenicity of the nitrosamine in the rat and rabbit, suggest that in the esophagus, at least, metabolic activation of NMBZA is necessary to elicit its toxic and/or carcinogenic effect. However, NMBZA is also metabolized at a high rate in the liver of all species but is not toxic or carcinogenic in this tissue, suggesting that other factors besides metabolic activation must be involved in the resistance of hepatocytes to the effects of the nitrosamine. Microsomes prepared from human esophageal mucosa from six patients metabolized NMBZA at rates that were either undetectable or approximately 70 times lower than in the Sprague-Dawley rat.

Animals↗

PubMed1984

Mixed hyperplastic adenomatous polyps--an underdiagnosed entity. Report of a case of adenocarcinoma arising within a mixed hyperplastic adenomatous polyp.

We report a case of colonic adenocarcinoma arising within a polyp with mixed morphology of a hyperplastic polyp and tubular adenoma. Despite the relatively small size of the polyp, two isolated foci of adenocarcinoma in situ were present and tumor islands invaded the submucosa. Isolated areas, morphologically resembling hyperplastic glands, and varying degrees of atypia. Though rare, some hyperplastic polyps may be precursors of adenomas.

Adenocarcinoma↗

PubMed1983

Colonic mucus in human fetal development.

The labelling behaviour of specimens of human fetal colon at different stages of development was examined using eight fluorescently labelled lectins with preferences for different carbohydrate structures. Peanut agglutinin (PNA) binding can be demonstrated in specimens from fetal colons between the 4th and 5th week and the 5th and 6th lunar month. Since CEA may bind to similar structures as PNA, an answer was sought to the question whether these structures are in fact identical. While there is evidence in favour of non-identity, it is not entirely conclusive. PNA-binding to fetal tissues is of interest since PNA binds to adult transformed colonic tissues, but not to normal ones.

Antigens, Neoplasm↗

PubMed1982

Giant cell carcinoma of pancreas with clear cell pattern in metastases.

A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, and the significance of a clear cell component in metastases is discussed.

Adenocarcinoma↗

PubMed1982

Argyrophil granules in the human pituitary.

In order to assess the value of the Grimelius silver method in adenohypophysial cell identification and adenoma diagnosis, 22 nontumorous adenohypophyses and 50 pituitary adenomas were investigated. Grimelius positivity was localized, as documented by mirror sections, predominantly in PAS and led hematoxylin positive cells; but a few negative cells contained argyrophil granules as well. The immunoperoxidase method revealed Grimelius positivity primarily in corticotrophs, thyrotrophs and gonadotrophs, and occasionally in somatotrophs and lactotrophs. Argyrophilia was readily demonstrated in 11 out of 13 corticotroph cell adenomas, in 1 out of 1 thyrotroph cell adenoma, in 5 of 11 null cell adenomas and in 4 out of 5 oncocytomas. No argyrophilia was detected in 5 growth hormone cell adenomas and 5 prolactin cell adenomas. One our of 5 mixed, growth hormone cell-prolactin cell adenomas, and 1 out of 5 acidophil stem cell adenomas showed Grimelius positivity. By electron microscopy, silver grains were localized in the secretory granules. It can be concluded that no specific hormonal products account for argyrophilia.

Adenoma↗

PubMed1980

Intrasellar solitary plasmacytoma terminating in multiple myeloma: a report of a case including electron microscopical study.

A case of multiple myeloma is reported that presented as a solitary plasmacytoma of the bone of the sella turcica. The diagnosis was established by electron microscopy in conjunction with the immunoperoxidase technique. The patient succumbed 37 months after the diagnosis was made. The relation between solitary plasmacytoma of bone and multiple myeloma is discussed. The differential diagnosis of intrasellar tumors may pose serious problems to the surgical pathologist. In difficult cases the value of the immunoperoxidase technique and electron microscopy is emphasized.

Female↗