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Biomedical subjects

S Kay

Publications and source records attributed to S Kay.

At least 127 records · Page 7Linked to original sources
PubMed1983

Choriocarcinoma of the mesosalpinx masquerading as congestive heart failure: ultrastructural observations of the tumor.

A 45-year-old woman suffered from hypertension and congestive heart failure for 5 months. She was found to have a choriocarcinoma of the left mesosalpinx. The final event was, in all probability, a massive pulmonary tumor embolus which occurred shortly after removal of the uterus and adnexae. The tumor was studied by immunohistochemical methods as well as ultrastructurally, and the findings are illustrated and described.

Adnexal Diseases↗
PubMed1983

The role of prophylactic antibiotics in appendectomy using delayed primary closure.

A prospective randomized trial of prophylactic antibiotics in 202 patients undergoing appendectomy is reported upon. The antibiotics used were metronidazole and cephradine. Half of the patients received antibiotics preoperatively. The other half received antibiotics at operation only upon finding perforation, gangrene or pus formation. All wounds were treated by delayed primary closure. No instance of wound infection, defined as abscess formation or cellulitis, occurred in either group. Antibiotics given prophylactically in every instance appear to have no advantage in preventing wound infection when delayed primary closure is used.

Adolescent↗
PubMed1982

Stercoral ulceration.

Stercoral ulceration is the loss of bowel integrity from the pressure effects of inspissated feces. The lesion usually occurs in constipated, bedridden patients and presents as an isolated lesion in the rectosigmoid area. Because of associated diseases in the population at risk, perforation and hemorrhage, the principal complications, result in a mortality exceeding 50 per cent. The diagnosis of perforated stercoral ulceration should be considered in any patient with a long-standing history of constipation who presents with acute abdominal pain and clinical findings consistent with perforation of a hollow viscus. Early celiotomy with vigorous debridement and irrigation of the peritoneal cavity and either exteriorization or resection with proximal colostomy is the treatment of choice. Since constipation and colonic dysfunction are more common in the older patient, as the mean age of the population increases, the surgeon may encounter this problem more often. Four patients with stercoral ulceration managed at the Medical College of Virginia Hospitals are added to the 53 patients previously reported in the literature.

Adult↗
PubMed1981

Febrile neutrophilic dermatosis associated with acute leukemia.

Febrile neutrophilic dermatosis (Sweet's Syndrome) is an uncommon syndrome characterized clinically by fever, neutrophilia, and erythematous, non-ulcerating papules or plaques on the face, neck, upper thorax, and extremities. A case associated with acute myelogenous leukemia is reported and nine other reported cases associated with acute non-lymphocytic leukemia are reviewed. The appearance and location of the lesions on the face, neck, upper trunk and extremities, a female predominance, an associated fever, marked dermal infiltrates of mature neutrophils, and rapid clearing of lesions with parenteral corticosteroids were manifestations similar to febrile neutrophilic dermatosis not associated with leukemia. Although the etiology of febrile neutrophilic dermatosis associated with acute leukemia is unknown, the resolution of lesions and symptoms with systemic corticosteroids and recurrence with relapse of leukemia suggests an immune process with the leukemic cell population serving as a possible antigenic source.

Aged↗
PubMed1981

Angiosarcoma and other vascular tumors of the breast.

Vascular tumors of the breast, with the exception of perilobular hemangiomas, are generally considered to be malignant. The pathologic and clinical features of 40 patients with angiosarcoma of the breast and 12 with other vascular tumors of the breast were reviewed. Three general histologic patterns of growth were identified among the angiosarcomas and were found to correlate closely with prognosis. Whereas 10 of the 13 patients in histologic Group I were alive and free of disease with an average follow-up of nearly 6 years, only two of 16 Group III patients were free of disease, and 14 have died. The six Group II patients had a survival similar to those in Group I. In this series the disease-free survival at 3 years was 41% and at 5 years 33%, much better than that reported in previous reviews of mammary angiosarcoma. The data also indicated that adjuvant chemotherapy, specifically actinomycin D, is effective in some and possibly all patients with angiosarcoma of the breast. The 12 other vascular lesions had distinctly different morphologic features, a benign clinical course, and should probably not be viewed as angiosarcomas. However, total excision of all vascular lesions of the breast is essential in order to determine both the diagnosis and the appropriate therapy.

Adult↗
PubMed1981

The pigmented portio: benign lentigo of the uterine cervix.

The first case of benign lentigo of the uterine cervix is reported, providing further evidence that the cervix is able to form the entire spectrum of melanocytic lesions known to occur in the skin. Review of the literature reveals 19 cases of primary malignant melanoma of the cervix and 30 cases of blue nevus. The reported case offers support that benign lentigines may play a role as premalignant lesions of malignant melanoma not only in the skin, but aldo in mucous membranes.

Adult↗
PubMed1978

Ultrastructural comparison between skeletal muscle and cardiac rhabdomyomas.

The electron microscope features of three primary cardiac rhabdomyomas and one skeletal muscle rhabdomyoma arising from the floor of the mouth are compared, along with a review of the previously reported ultrastructural features of skeletal rhabdomyomas. Cardiac rhabdomyoma filaments appear more orderly and have features suggestive of origin from both Purkinje and myocardial fibers. Zebra bodies were seen exclusively in the cardiac rhabdomyomas. In comparison, the extracardiac rhabdomyoma filaments were more disorderly and many cases had hypertrophic Z bands corresponding to the jackstraw or matchstick structures seen with the light microscope. This finding, along with the presence of satellite cells, was not seen in the cardiac rhabdomyomas.

Heart Neoplasms↗
PubMed1978

Inflammatory fibrous histiocytoma (? anthogranuloma). Report of two cases with ultrastructural observations in one.

Two cases of inflammatory fibrous histiocytoma are presented, one occupying the pleural space, and the other the retroperitoneum. One of the cases was studied with the electron microscope and confirmed the histiocytic and xanthomatous nature of the lesion. It is suggested that the term xanthogranuloma be replaced by fibrous histiocytoma, and that when a considerable inflammatory component is present in the stroma, a guarded prognosis be entertained. Ultrastructurally there are no distinctive features for the inflammatory variant of the fibrous histiocytoma.

Histiocytoma, Benign Fibrous↗
PubMed1978

Preoperative radiotherapy for stage III carcinoma of the breast.

We have concluded from these observations in this pilot study that preoperative radiation therapy does not play a particularly helpful role in the management of patients who have the clinical finding of borderline operable carcinoma of the breast and it does not improve the survival rate. Patients within this category of locally advanced disease must be considered to have systemic metastatic disease at the time of diagnosis, as has previously been stressed by many. For this reason, any therapy directed to the regional area for local control must be combined with some form of systemic therapy if there is to be any hope for an increase in survival time.

Adult↗