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Biomedical subjects

S Kolb

Publications and source records attributed to S Kolb.

At least 55 records · Page 3Linked to original sources

[Experiences with totally implantable catheter systems in home parenteral nutrition].

Totally implantable catheter systems have proved their qualification in patients treated with intravenous chemotherapy. These systems appear to have also advantages in patients requiring home parenteral nutrition. The risks of infection can be minimized, daily dressing changes are not necessary, and the cosmetic appearance is not influenced.

Adolescent↗

Artificial parenteral nutrition at home via totally implantable catheter systems.

Home parenteral nutrition ensures the nutritional requirements in patients where oral or enteral food intake is not sufficient. This report describes the use of totally implantable catheter-port-systems that are punctured only during infusion periods. Using these systems, the quality of life at affected patients can be substantially improved. Moreover, the rate of complications such as septicemia and mechanical problems appears to be significantly reduced in comparison to conventional catheters employing extracorporal segments.

Adolescent↗

[Ambulatory tube feeding. An alternative to parenteral feeding].

Nowadays, enteral tube feeding is an alternative to parenteral nutrition in hospitalized patients. Special tubes and differentiated diets enable a high quality, enteral nutrition, which can be well applied for a number of indications without complications. This tube feeding can also be managed in ambulatory patients with benign or malignant diseases. The education, training and surveillance of these patients is a necessary requirement. Mobility and living habits of the patients are hardly disturbed at all by this regimen. Deficiencies due to the exclusive application of a chemically defined diet need not to be feared.

Ambulatory Care↗

[Anorexia nervosa. A catamnestic analysis].

Over a period of 10 years 25 patients, 24 of them females, with anorexia nervosa were observed. The disease is characterized by marked loss of weight, amenorrhoea, low blood pressure and early-onset behavioural disorders towards members of the family and friends. Anaemia, peripheral oedema and pronounced muscular weakness due to electrolyte imbalance may be observed in advanced cases. The disease commences in puberty by more or less obvious loss of weight following reduced food intake, rarely it is caused by vomiting and laxative abuse. Patients tend to deny connections between reduced food intake and loss of weight. There is no standardized treatment. Therapy should be initiated by the psychiatrist. In severe cases parenteral nutrition and intensive care may be required. This is particularly true in complicated cases such as occurrence of infection, serious electrolyte disorders or coagulation defects. The earlier a diagnosis is made the better the prognosis. Manifest disease of more than 5 years' duration decreases the chances for cure considerably.

Adolescent↗

[Low-sugar and fiber-rich diet in Crohn disease].

Nutrition apparently plays an important role in the etiology of Crohn's disease. Possible influences by commercially produced foodstuffs and their additives together with changes in composition of the diet are discussed. Several examiners could show, that patients with Crohn's disease even prior to the beginning of their illness have a significantly increased consumption of refined carbohydrates if compared to a control group. Therapeutic regimes with reduction of synthetic carbohydrates as well as increase in crude fiber content of the diet have demonstrated a positive influence on the disease. Besides the conventional drug therapy a simultaneous diet as described appears to have a favorable influence on both acute attacks of the disease as well as extending the state of remission.

Crohn Disease↗

[Does short-term fasting lower the cardiovascular risk in obesity? Effects of the composition of the reducing diet].

Risk factors of atherosclerosis in obese people can be reduced by weight reduction. 40 massively obese patients (Broca 159 +/- 41) were treated with different hypocaloric weight reduction diets. It was tested, if a decrease of risk factors can be induced by a 14 days' treatment period, already, and if the composition of diet influences the results. Weight reduction induced a significant fall of blood pressure and triglycerides (-25%). No differences could be seen between the various diets. The decrease of cholesterol (-12%) was caused by a simultaneous fall of LDL- and protective HDL-cholesterol. These changes were independent from dietary composition, too.

Adult↗

[Treatment of hyperuricemia during cytostatic therapy].

The increase in serum uric acid induced by cytostatic drugs may be treated by a combined low-dose uricostatic and uricosuric regimen. The results obtained in an intraindividual cross-over study demonstrate the significant influence on serum uric acid and its renal excretion.

Adenocarcinoma↗

[Lead poisoning - also today still current].

Even today lead intoxication may occasionally occur. As shown in this case report, careful history including that of the occupational environment may cause suspicion, when complaints such as abdominal pain and constipation are associated with erythrogenic disturbances due to inhibition of certain enzymes of hem synthesis. Although changes in peripheral blood and bone marrow may be typical, lead intoxication can definitely be diagnosed only by determination of lead in blood and urine, of accumulated porphyrins in the red blood cells and of the typical pattern of hem precursors in the urine. Finally, this report deals with the therapy of lead intoxication.

Adult↗

[Experiences with a chemically modified monospecies-insulin].

In a randomised clinical study 20 diabetics were given a des-phe-mixed-insulin. The quality of diabetes control was investigated. The average age of the patients was 53 years; the duration of the diabetes was 8.7 years in average. As criterion of diabetes control were accepted: a daily urinary excretion up to 10 g and a peak value of blood-sugar in the daily profile of 9.99 mmol/l (180 mg/dl). In 9 of the 20 patients the diabetes could be controlled easily by using des-phe-mixed-insulin. In the remaining 11 patients no sufficient control was achieved. These 11 patients were treated successfully within five days using a highly purified insulin from the pig (Mixtard). Compared to the des-phe-mixed-insulin the dose could be reduced by 26% in average. Two patients developed an allergy against the des-phe-mixed-insulin; one locally, one generalized.

Adolescent↗

"Walking" in the newborn.

Brief daily exercise of the walking and placing reflexes in the newborn leads to a high rate of responding by 8 weeks and to an earlier onset of walking alone. There appears to be a critical period during which the walking response can be transformed intac from a reflexive to an instrumental action.

Age Factors↗