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Biomedical subjects

S Kolb

Publications and source records attributed to S Kolb.

60 records · Page 4Linked to original sources

In vitro model for the evaluation of inferior vena cava filters: effect of experimental parameters on thrombus-capturing efficacy of the Vena Tech-LGM filter.

PURPOSE: To determine the experimental parameters in an in vitro model that influence the thrombus-capturing efficacy of the Vena Tech-LGM filter. MATERIALS AND METHODS: The Vena Tech-LGM filter was evaluated in an in vitro model of the vena cava with a computer-controlled flow system with a total of 5,200 thrombi. The influences of the following experimental parameters on the capture rate were analyzed with a multiple logistic regression model: type of testing (single, double, and multiple shot testing), thrombus diameter and length, IVC diameter and orientation, flow quality and quantity, flow velocity, and the length of the prepositioned thrombus. RESULTS: A significant influence on the capture rate could be demonstrated for the type of testing, the thrombus diameter and length, the IVC diameter, and with double shot testing for the length of the prepositioned thrombus and the IVC orientation. The flow quality and the peak velocity were not significant. Based on these results, a protocol for in vitro testing of IVC filters was designed. CONCLUSIONS: Experimental parameters influence the thrombus-capturing efficacy of the Vena Tech-LGM filter and should be taken into account when in vitro testing is performed.

Filtration↗

Effect of fat emulsions containing medium-chain triglycerides and glucose on ketone body production and excretion.

The parenteral application of fat emulsions containing medium-chain triglycerides results in an increase of ketone bodies as expression of the rapid metabolism of medium-chain triglycerides. Although ketoacidosis could not be watched, it should be of advantage to reduce the ketonemia. This might be reached by application of carbohydrates. The simultaneous infusion of glucose--given to 10 healthy persons--together with a 10% fat emulsion containing 75% medium-chain triglycerides almost completely inhibited the increase of ketone bodies in serum and its urinary excretion. Other prosperous metabolic effects, eg, the rapid clearance of the triglycerides from the serum were not affected by this regimen.

3-Hydroxybutyric Acid↗

Comparison of the activity profiles of two fixed combinations of regular/NPH human insulin (recombinant DNA) of different compositions with a fixed regular/NPH porcine insulin combination (PPI) in insulin-dependent diabetic individuals.

In a randomized double-blind crossover study, 10 insulin-dependent diabetic individuals were treated with a commercial brand of neutral, highly purified porcine insulin (PPI) with 30% regular and 70% NPH fractions (Mixtard, Nordisk, Denmark), and with human insulins (recombinant DNA) with 20% regular and 80% NPH fractions, and with 30% regular and 70% NPH fractions. Each of the preparations was given for 4 consecutive days. The human insulin combination with the 20% regular and 80% NPH components showed a similar activity profile as the PPI 30/70 combination. In contrast, the human insulin combination with the 30% regular and 70% NPH fractions produced substantially lower blood sugar concentrations with the associated risk of hypoglycemia.

Adult↗

[Conception and pregnancy without complications in parenteral home nutrition].

A case is reported of conception and successful completion of a pregnancy in a 31 year old woman maintained on home parenteral nutrition while suffering from a primary distension of the intestinal lymphatic vessels and intestinal loss of protein. A healthy, 3400 g female infant was born near term by cesarean section. This case confirms the few so far published experiences showing that conception and maintenance of the pregnancy under total parenteral nutrition needs no or just a slight adaptation of the regimen.

Adult↗

Effects of relaxation on anxiety in primary caregivers of chronically ill children.

PURPOSE: To evaluate the effects of self-applied breathing and guided imagery relaxation techniques, separately and in combination, and a reinforcement tool on primary caregivers (PCGs) coping with anxiety when caring for a chronically ill child. METHOD: Twenty PCGs, aged 25-57, of chronically ill children were randomly assigned to an experimental or control group. The State Anxiety Scale of the State-Trait Anxiety Inventory (Form Y) was used to measure state anxiety across three test administrations. FINDINGS: While there were no statistically significant changes in state anxiety, behavioral evaluations indicated that PCGs used both the self-applied relaxation techniques and the reinforcement tool more than twice daily. CONCLUSIONS: Relaxation techniques may be useful for those people caring for chronically ill children.

Adaptation, Psychological↗