Biomedical subjects
Publications and source records attributed to S Lanzafame.
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We have chosen 10 medullary carcinomas from a retrospective investigation on 450 cases of breast carcinoma (2.2%), according to the histomorphological criteria of Ridolfi and colleagues. By immunoperoxidase staining, we have evaluated the distribution of keratin and vimentin intermediate filaments, of CEA and S-100 protein in cancer cells. A widespread positivity to keratins has been proved in 70% of medullary carcinomas. Numerous neoplastic cells have coexpressed S-100 protein. We hypothesize the epithelial and myoepithelial "intermediate" differentiation of keratin and S-100 protein positive tumour cells.
We report a case of extramammary Paget's disease arising in the anogenital region in association with an underlying sweat gland microcarcinoma. Paget's cells were investigated with monoclonal anti-EMA and anti-cytokeratin antigen and with mono- and polyclonal anti-CEA antigen. Positive immunostaining was observed in Paget's cells and in the underlining tumor, whereas keratinocytes and melanocytes did not stain. CEA was also detected in cells and secretions of normal apocrine glands. The immunohistochemical use of polyclonal anti-keratin and anti-S-100 protein antigen is helpful in differentiating Paget's disease from other morphologically similar skin lesions, such as Bowen's disease and superficial spreading melanoma in situ.
The clinical and pathologic findings of four cases of palpable sclerosing adenosis of the breast, called "adenosis tumor", are reported. Adenosis tumor is a rare lesion that clinically and sometimes histologically is misinterpreted as mammary carcinoma. In our study, adenosis tumor was detected in four women of 35-39 years (average 37 years). All cases were treated by local excision. None of the lesions had recurred at follow-up, 1-3 years later. Microscopically the most frequent growth pattern was classical sclerosing adenosis. Other findings were epitheliosis, collagenous spherulosis, microcysts, apocrine metaplasia and radial scars. Only in one case were detected foci of lobular carcinoma in situ. With immunoperoxidase staining, the proliferating cells stained positively for cytokeratin (AE1/AE3) and actin, revealing epithelial and myoepithelial differentiation. Coexpression of actin, S-100 protein and GFAP was detected in numerous stromal myofibroblast-like cells. In sclerosing adenosis and in radial scar the tubules were surrounded by a continuous intact basement membrane composed of type IV collagen, whereas in tubular carcinoma basement membranes are almost entirely absent.
Gastric carcinoma of hamartomatous histogenesis. Case report and review of the literature. A rare case of adenocarcinoma arising in adenomyomatous hamartoma of the pyloric wall is presented and the literature reviewed.
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Cutaneous lymphoid hyperplasia (CLH) is a reactive proliferation of SALT--skin-associated lymphoid tissue--following trauma, insect bites, drugs and other undetermined stimuli. Only a case of CLH resulted from allergy hyposensitization injections was reported in literature. We report a second case of post-vaccinal CLH occurred in a 37 year-old man. A light microscopic and immunohistochemical study was performed. CLH immunoarchitectural analysis revealed features analogous to those of reactive lymph nodes.
The Authors report a rare case of perforated diverticulitis of the cecum. The patient was a 68-year-old man who was referred to the Authors attention with the classic symptoms of acute appendicitis. During laparotomy a perforated "omentum-sealed" diverticulum was found on the lateral wall of the cecum, whereas the appendix appeared to be completed unaffected. A right hemicolectomy was performed. The Authors analyse the similarities and peculiarity of the case. Special attention is drawn to the problems of differential diagnosis raised by this pathology. A preoperative diagnosis is arduous because the disease is difficult to distinguish from acute appendicitis and may be even difficult to distinguish it intraoperatively from a carcinoma of the cecum. There is no characteristic clinical pattern pointing to this diagnosis. Diagnostic maneuvers are usually unrewarding. Right hemicolectomy is a safe procedure when the diagnosis is doubtful.