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Biomedical subjects

S Lifshitz

Publications and source records attributed to S Lifshitz.

50 records · Page 3Linked to original sources
PubMed1980

Treatment of carcinoma in situ of the vulva with topical 5-fluorouracil.

Topical 5-fluorouracil (5-FU) has been suggested as a simple and effective approach to the treatment of carcinoma in situ of the vulva. In this study, 12 patients with carcinoma in situ of the vulva were evaluated and treated with topical 5-FU. Satisfactory results were obtained in 2. The nonresponders have subsequently undergone surgical therapy. Follow-up to date has been 9 to 96 months (average 38 months). The value of topical 5-FU in the treatment of carcinoma in situ of the vulva seems to be limited. Its use in vulvar neoplasia is discussed.

Administration, Topical↗
PubMed1978

Intraarterial pelvic infusion chemotherapy in advanced gynecologic cancer.

Fourteen patients with advanced localized gynecologic cancer were treated with 44 courses of intraarterial pelvic infusion chemotherapy. All patients received methotrexate with folinic acid rescue; 9 patients also received vincristine. Tumor regression was observed in 3 of 14 patients (21.4%). In 5 patients there were major complications related to 28 intraarterial catheter placements. Two patients developed leukopenia following chemotherapy. The value of intraarterial infusion chemotherapy in gynecologic cancer is limited. Its use in gynecologic oncology is discussed.

Adult↗
PubMed1977

Pyometra complicating radiation therapy of uterine malignancy.

This report concerns our experience with the clinical management of pyometra in 12 patients receiving radiation therapy at the University of Iowa Hospitals and Clinics for uterine epithelial malignancy. The effect of pyometra on radiation therapy is discussed. Adequate drainage is imperative, and appropriate cultures should be obtained. External radiation therapy may be continued as planned; however, intracavitary radium applications should be deferred.

Adult↗
PubMed1976

The role of scalene lymph node biopsy in advanced carcinoma of the cervix uteri.

Considerable controversy exists in the role of scalene lymph node biopsy in the pretreatment assessment of patients with carcinoma of the cervix uteri. Scalene lymph node biopsy was carried out on ten patients having advanced carcinoma of the cervix uteri with documented para-aortic nodal involvement. Metastatic carcinoma was found in the scalene lymph nodes in five of ten patients. These preliminary findings suggest that excision of scalene lymph nodes should be carried out prior to the institution of therapy in all patients with carcinoma of the cervix uteri which is metastatic to the para-aortic lymph nodes.

Adult↗
PubMed1976

Subarachnoid phenol block for pain relief in gynecologic malignancy.

One hundred and thirty-three subarachnoid phenol blocks were performed in 90 patients with intractable pain secondary to gynecologic cancer at the University of Iowa Hospitals in the period 1961 to 1975. Excellent to moderate pain relief was obtained in 77% of 117 evaluable blocks. Fifty-two percent of the blocks gave relief of over 1 months' duration and 27% over 2 months. Fourteen patients had a second contralateral block and 11 obtained 4 to 8 weeks' relief. Complications were temporary and occurred in 71% of the blocks, the most common being urinary and rectal incontinence. Subarachnoid phenol block is an effective method for relief of intractable pain; its use in gyneclogic oncology is discussed.

Analgesia↗
PubMed1975

Disseminated intravascular coagulation in gynecologic cancer.

Disturbances in the blood coagulation mechanism are seen by the obstetrician and gynecologist as rare complications of abruptio placentae, retained dead fetus syndrome, amniotic fluid embolism, toxemia, saline amnioinfusion, and septic abortion. Two cases of disseminated intravascular coagulation complicating gynecologic malignancy are presented. Laboratory studies showed thrombocytopenia, hypofibrinogenemia, and increased fibrin degradation products. Derangements of hemostasis in patients with malignancy are discussed from a clinical viewpoint.

Blood Coagulation Tests↗