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Biomedical subjects

S Lindenberg

Publications and source records attributed to S Lindenberg.

At least 73 records · Page 4Linked to original sources
PubMed1986

Effect of simulated joint effusion on subchondral haemodynamics and metabolism.

The purpose of the present study was to investigate the effect of simulated joint effusion on pO2, pCO2, the regional blood flow and intraosseous bone marrow pressure in the subchondral bone of rabbit. Mass spectrometry was used for simultaneous and continuous registration of subchondral pO2 and pCO2, while the relative argon signal was used for qualitative estimation of regional bone blood flow. The bone marrow pressure was recorded continuously by pressure transducers. Isotonic sodium chloride infusion at a constant pressure of 75 mmHg into the knee joint cavity constituted the basis for joint effusion. An instant increase in the subchondral bone marrow pressure followed the joint effusion (P less than 0.001). This resulted in a significant (P less than 0.01) decrease in the qualitative bone blood flow, significant (P less than 0.01) hypoxia and significant (P less than 0.01) hypercapnia in the subchondral bone. Joint effusion always lasted 30 minutes. Following its release all changes were reversed to normal values within 15 minutes. Within the period of observation no nervous or humoral factors seem to be brought into action. It was concluded that regional venous stasis was responsible for all changes, and that joint effusion should not be left untreated for long periods.

Animals↗
PubMed1986

Ultrastructure of the early human implantation in vitro.

Four hatched human blastocysts obtained after in-vitro fertilization and development were placed on monolayer cell cultures of human endometrial epithelium, and subsequently examined by transmission electron microscopy. All four blastocysts became adherent to the monolayer and three implanted and exhibited outgrowth of their trophoblastic cells. During implantation the blastocysts differentiated into mural and polar trophoblastic cells, and embryonic cells including endodermal cells. The endometrial cells were displaced and stacked into a multilayer at the periphery of the implantation sites, allowing the trophoblastic cells to come in contact with the culture dish. The endometrial cells displayed local exo- or endo-cytosis where they contacted the trophoblastic cells. The trophoblastic cells were not observed to be phagocytosing endometrial cells. These observations suggest that human blastocysts portray an intrusive type of implantation during the initial stages.

Blastocyst↗
PubMed1985

Ectopic pregnancy and spontaneous abortions following in-vitro fertilization and embryo transfer.

In-vitro fertilization and embryo transfer was performed in 25 patients with diseased oviducts. Three pregnancies were achieved, but all ended in early abortion. One patient had ectopic pregnancy, one spontaneous abortion having a severe autosomal chromosome abnormality, and one had a rise in serum hCG but vaginal bleeding started 18 days after embryo transfer. We conclude that repeated ultrasonic examinations of all pregnancies following in-vitro fertilization and embryo transfer is recommendable until intra-uterine implantation has been confirmed and that amniocentesis should be offered to all these patients.

Abortion, Spontaneous↗
PubMed1985

Serous synovitis of the sternoclavicular joint. Differential diagnostic aspects.

Ten patients with unilateral spontaneous swelling of the sternoclavicular joint are presented. Plain radiographic examination of the joints revealed no abnormalities. Technetium scintigraphy was positive. After surgical biopsy the swelling and the symptoms disappeared. Patho-anatomical examination of synovialis from these joints revealed serous synovitis as the only pathological finding. Seven other patients with clinical symptoms undistinguishable from the above-mentioned and with normal plain radiographic findings showed, patho-anatomically: osteomyelitis (2 cases), ganglion (2 cases), osteoarthritis (1 case), Friedrich's disease (1 case) and a carcinoma metastasis (1 case). In view of the differential diagnostic aspects it was concluded that diagnosis of spontaneous swelling of the sternoclavicular joint after inconclusive serological, radiographical and scintigraphical examination, always should be established on the basis of surgical biopsy and patho-anatomical evaluation.

Aged↗
PubMed1985

Studies on prevention of intra-abdominal adhesion formation by fibrin sealant. An experimental study in rats.

The preventive effect of fibrin sealant on post-operative formation of peritoneal adhesions was investigated in rats. Intraperitoneal adhesion formation was induced with a standardized, sutured defect in the peritoneum. The influence of sealant thickness and lifetime was evaluated by application of a thin and a thick layer of fibrin sealant containing high or low concentration of antiplasmin. Assessment of adhesion formation one week post-operatively showed significantly less adhesion to the defects covered with the thick layer of sealant having high or low antiplasmin concentration as compared with defects having only a thin sealant layer or control rats without sealant.

Animals↗
PubMed1984

Prevention of peritoneal adhesion formation by fibrin sealant. An experimental study in rats.

The preventive effect of rat and human fibrin sealing on intra-abdominal adhesion formation was investigated in 40 rats. Intraperitoneal adhesion formation was induced by excision of 1 X 3 cm of the peritoneal parietalmuscular layer, subsequently closed by interrupted 3-0 silk sutures. A total of 80 defects were allocated to one of four treatments: 1) the defect was covered with human fibrin sealant with the aid of a syringe. 2) the defect was covered with rat fibrin sealant with the aid of a syringe. 3) the defect was covered with human fibrin sealant with the aid of a spray. 4) the defect was not covered (control group). Assessment of the adhesion formation one week postoperatively showed that the median length of adhesions in defects covered with fibrin sealant applied by a syringe (10.5 mm) or by spray (14 mm) was less than that of the control group (25 mm) to a significantly high degree (P less than 0.001). It is concluded that fibrin sealant prevents intraperitoneal adhesion formation in the present rat model.

Animals↗
PubMed1983

Sterilization by vas occlusion without transection does not reduce postvasectomy sperm-agglutinating antibodies in serum. A randomized trial of vas occlusion versus vasectomy.

The influence of transection of the vasa on the increase in sperm-agglutinating activity in serum after vasectomy was investigated in a prospective randomized study. Sixty-eight males requesting vasectomy were allocated to either of two groups: vas occlusion by tantalum clips without transection of the vasa, or conventional vasectomy by transection and ligation. Sperm-agglutinating antibodies were determined by a micro-agglutination test before and 6 months after vasectomy or vas occlusion. A significant increase in sperm-agglutinating activity in serum after sterilization was found in both groups, but there was no intergroup difference.

Adult↗