PubMed Health⌕ Search

Biomedical subjects

S N Orekhov

Publications and source records attributed to S N Orekhov.

9 recordsLinked to original sources
PubMed1989

[Is ethanol a stressogenic factor for rats with a developed alcohol motivation?].

The male outbred rats, placed in common cages, demonstrated dose- and time-dependent increase of blood plasma ACTH level after handling and acute ethanol administration (1 and 4 g/kg). The pituitary response of isolated rats under condition of free choice between water and 15% ethanol solution was more pronounced after handling. Ethanol (4 g/kg) did not increase plasma blood level ACTH in isolated alcohol motivated rats. It also prevented blood plasma ACTH rise under condition of handling. The dual role of acute ethanol as a stressogenic and antistressogenic factor in naive and alcoholic rats is discussed.

Adrenocorticotropic Hormone↗
PubMed1989

[Tranquilizers].

Explore the source record for details and available documents.

Anti-Anxiety Agents↗
PubMed1988

[Positive modulation of diazepam activity by cortexolone in alcoholic rats].

It has been shown that glucocorticoid receptor antagonist-cortexolone--increased anxiolytic action of diazepam in alcoholic rats. Neither diazepam (2 mg/kg), nor cortexolone (20 mg/kg) alone influenced voluntary ethanol consumption in alcoholic rats during 14 days of administration, however, combined administration of diazepam and cortexolone diminished ethanol consumption. Receptor and permissive mechanism of gluco- and antiglucocorticoid effect on the action of diazepam are being discussed.

17-Hydroxycorticosteroids↗
PubMed1987

[Cortexolone as a modulator of diazepam activity].

The influence of ACTH (200 micrograms/kg), corticosterone (20 mg/kg) and cortexolone (20 mg/kg) on the anxiolytic activity of diazepam was studied. ACTH partly and corticosterone completely blocked the action of diazepam. Cortexolone injection 30 min before the administration of diazepam induced a 100% anxiolytic effect of diazepam in the range of doses from 0.1 to 0.3 mg/kg (ED50 of anxiolytic diazepam effect is 0.2 mg/kg). The role of stress hormones in the regulation of psychotropic drug activity is discussed.

17-Hydroxycorticosteroids↗
PubMed1986

[Role of benzodiazepine receptors in realizing the anxiolytic effect of compounds on intact rats and on animals with a physical dependence ethanol].

Anxiolytic activity of DSIP, sodium hydroxybutyrate, nicotinoyl-GABA, mebicar, some derivatives of aminoandrostane and beta-carboline was not, like in the case of diazepam and beta C-3CEE, related to benzodiazepine receptors. The degree of the decrease in anxiolytic activity of these compounds did not correspond to increasing Ki binding of 3H diazepam in alcoholic rats.

Alcoholism↗
PubMed1985

[Anxiolytic action of beta-carbolines in rats].

The decreased sensitivity to the anxiolytic action of diazepam, BC-3-KEE, IME-6MEO-TGBC, IME-6MEO-DBC was shown in rats with experimental alcoholism. The degree of the decreased sensitivity was dependent on the affinity of the compounds to benzodiazepine receptors.

Alcoholism↗
PubMedDate not supplied

[Psychotropic properties of hormonally inactive derivatives of androstane].

It has been shown in experiments on noninbred male rats that 17 beta-acetylamino-5-androstene-3 beta,16 beta-diol, 17 beta-amino-5-androstene-3 beta,16 beta-diol hydrochloride, and 17 beta-acetylamino-4-androstene-3,16-dione have an anxiolytic action. These compounds do not exhibit any myorelaxant, anticonvulsant or antineurotic activity common to benzodiazepine tranquilizers. The anxiolytic effect of the compounds under consideration is coupled with the ability to reduce the level of alcoholic motivation in rats.

Alcoholism↗