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PubMed · 3593949

[Cortexolone as a modulator of diazepam activity].

N N Vedernikova·S N Orekhov·I P Borisova·Iu V Burov
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Abstract

The influence of ACTH (200 micrograms/kg), corticosterone (20 mg/kg) and cortexolone (20 mg/kg) on the anxiolytic activity of diazepam was studied. ACTH partly and corticosterone completely blocked the action of diazepam. Cortexolone injection 30 min before the administration of diazepam induced a 100% anxiolytic effect of diazepam in the range of doses from 0.1 to 0.3 mg/kg (ED50 of anxiolytic diazepam effect is 0.2 mg/kg). The role of stress hormones in the regulation of psychotropic drug activity is discussed.

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17-HydroxycorticosteroidsAggressionAnimalsConflict, PsychologicalCorticosteroneCortodoxoneCosyntropinDiazepamDose-Response Relationship, DrugDrug InteractionsRatsStress, PhysiologicalComparative StudyJournal Article

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BibTeXRIS

N N Vedernikova, S N Orekhov, I P Borisova, Iu V Burov. 1987. [Cortexolone as a modulator of diazepam activity].. https://pubmed.ncbi.nlm.nih.gov/3593949/

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