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Biomedical subjects

S Nolting

Publications and source records attributed to S Nolting.

At least 19 recordsLinked to original sources
PubMed1992

Clinical relevance of the antibacterial activity of terbinafine: a contralateral comparison between 1% terbinafine cream and 0.1% gentamicin sulphate cream in pyoderma.

The antibacterial efficacy of 1% terbinafine cream and 0.1% gentamicin sulphate cream was evaluated in 33 patients with superficial staphylococcal pyoderma in a double-blind contralateral comparison. After 12 days of active treatment, Staphylococcus aureus could be grown from only one out of 33 patients using terbinafine vs no patient using gentamicin. At the end of the study, a marked improvement in clinical symptoms was observed with no significant difference between the two therapies. Despite reviewing the patients three times during the course of the study, no adverse events were reported. The results of this study demonstrate that terbinafine has clinically relevant antibacterial properties which may be useful not only in pyoderma, but also in mixed fungal/bacterial infections, such as athlete's foot.

Adolescent↗
PubMed1992

Double-blind comparison of amorolfine and bifonazole in the treatment of dermatomycoses.

A total of 232 patients with mycoses of skin folds, body, or feet were entered into a double-blind, parallel group-study. Therapy with 0.125, 0.25, 0.5% amorolfine cream or 1% bifonazole cream was randomly allocated to patients. The cream was applied once daily for 4 weeks on average. At screening, in 208 patients evaluated for efficacy, a total of 225 fungi were isolated: T. rubrum (77), T. mentagrophytes (65), other dermatophytes (15), C. albicans (34), other yeasts (26) and moulds (8). One to three weeks after ending therapy, the percentage of patients with negative cultures were as follows: 87.3, 91.7, 90.7 and 92.2% in the amorolfine cream 0.125%, 0.25%, 0.5% and bifonazole cream 1% groups respectively. The differences were not statistically significant. Six out of 223 patients evaluated for safety had local adverse events: one (1.7%), two (3.6%) and three (5.4%) in the amorolfine cream 0.125%, 0.25% and bifonazole cream 1% groups respectively. The most common local adverse events were burning and increased itching, erythema or weeping. A once-daily application of amorolfine cream can be recommended for the treatment of dermatomycoses on the basis of the results from this study. However, a further and similar study with a larger number of patients was required to select the concentration of amorolfine cream for therapeutic use.

Antifungal Agents↗
PubMed1990

[Mycoses in adolescent patients].

Mycoses affect people of all ages world wide. Furthermore, different fungi can produce the same clinical signs and symptoms, equally similar fungi can produce many different clinical pictures. Despite of this, particular fungal infections are found more common in people of certain age groups than in others. For example, candidosis is seen frequently in babies whereas fungal infections of the feet rarely occur in children. However, there is little difference in the fungi affecting adolescents and adults. Then again, elderly people are more vulnerable to candidal infections. Besides this, there is a current increase in fungal infections in immunosuppressed patients of any age.

Adolescent↗
PubMed1989

[Onychomycoses and their successful therapy].

Fungus-infected nail material in onychomycoses can be very well removed with a combination of 1% Bifonazol and 40% urea cream, thus eliminating other methods of treatment. It is to be stressed however, that the effectiveness of this therapeutic measure is not only due to the successful galenic and dual combination of these therapeutics, but also requires expert dermatological guidance and consequent cooperation by the affected patient to achieve a satisfactory and permanent result.

Administration, Topical↗
PubMed1989

[Urea treatment of mycoses].

Urea has been neglected up to now as a therapeutic agent in the field of mycology. This does not have to remain so in the future since urea preparations do have properties which improve the prospects for successfully treating mycoses. Moreover, urea does not produce any undesirable side effects on human skin.

Administration, Topical↗
PubMed1988

Treatment of impetigo and ecthyma. A comparison of sulconazole with miconazole.

In a randomized, double-blind, parallel comparative study of 80 patients, impetigo and ecthyma were treated effectively by sulconazole nitrate 1% cream and miconazole nitrate 2% cream applied to lesions twice daily for 14 days. When treatment began, bacterial cultures from all pyodermal lesions yielded Group A beta-hemolytic streptococci or pathogenic staphylococci. Among the 32 sulconazole-treated impetigo patients, bacterial cultures from 26 (69%) were negative by treatment day 4, and those from all 32 (100%) were negative by treatment day 7; among the 34 miconazole-treated impetigo patients, cultures from 17 (50%) were negative by treatment day 4, cultures from 32 (94.1%) were negative by treatment day 7, and cultures from 29 (97%) were negative by treatment day 14. Each treatment promptly relieved the pyodermal signs (crusts, vesicles, pustules, bullae, and exudate). Both agents were considered to be safe and effective medications for treating impetigo and ecthyma.

Double-Blind Method↗
PubMed1985

[Treatment with topical corticosteroids in severe or resistant dermatoses].

The efficacy and safety of betamethasone dipropionate glycol cream 0.05% and desoximetasone ointment 0.25% were compared in a randomized, double-blind study of 80 patients with resistant or severe corticosteroid-responsive dermatoses. Medication was applied to affected areas at a dosage of 3.5 grams twice daily for 14 days. In each treatment group, evaluation of efficacy was based on results in 35 patients and that of safety in 40 patients. Among betamethasone dipropionate glycol cream 0.05%-treated patients, signs and symptoms of dermatologic disease either cleared completely or markedly improved in 34/35 (97%). Comparable responses were observed in 31/35 (89%) patients treated with desoximetasone ointment 0.25%. Local tolerance to both study medications was excellent; no adverse reactions occurred. Plasma cortisol reduction occurred in few patients (4 resp. 3 patients each group), however this effect was only transient and reversible.

Adolescent↗
PubMed1979

[Predisposing factors in candidiasis].

The Candida mycosis is an infection by Candida albicans and other Candida species. This disease is not initiated by contact of Candida with the normal skin and mucous membranes or by invasion into the healthy host. On the contrary the presence of predisposing factors is important to Candida mycosis. These predisposing factors are considered as an impairment of local and/or general immunity and transform the opportunistically pathogenic character of the fungus into a parasitic one. Thus the host's defence mechanisms alone favour the development of Candida mycosis.

Bacterial Infections↗