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Biomedical subjects

S Nolting

Publications and source records attributed to S Nolting.

At least 37 records · Page 2Linked to original sources
PubMed1988

Treatment of impetigo and ecthyma. A comparison of sulconazole with miconazole.

In a randomized, double-blind, parallel comparative study of 80 patients, impetigo and ecthyma were treated effectively by sulconazole nitrate 1% cream and miconazole nitrate 2% cream applied to lesions twice daily for 14 days. When treatment began, bacterial cultures from all pyodermal lesions yielded Group A beta-hemolytic streptococci or pathogenic staphylococci. Among the 32 sulconazole-treated impetigo patients, bacterial cultures from 26 (69%) were negative by treatment day 4, and those from all 32 (100%) were negative by treatment day 7; among the 34 miconazole-treated impetigo patients, cultures from 17 (50%) were negative by treatment day 4, cultures from 32 (94.1%) were negative by treatment day 7, and cultures from 29 (97%) were negative by treatment day 14. Each treatment promptly relieved the pyodermal signs (crusts, vesicles, pustules, bullae, and exudate). Both agents were considered to be safe and effective medications for treating impetigo and ecthyma.

Double-Blind Method↗
PubMed1985

[Treatment with topical corticosteroids in severe or resistant dermatoses].

The efficacy and safety of betamethasone dipropionate glycol cream 0.05% and desoximetasone ointment 0.25% were compared in a randomized, double-blind study of 80 patients with resistant or severe corticosteroid-responsive dermatoses. Medication was applied to affected areas at a dosage of 3.5 grams twice daily for 14 days. In each treatment group, evaluation of efficacy was based on results in 35 patients and that of safety in 40 patients. Among betamethasone dipropionate glycol cream 0.05%-treated patients, signs and symptoms of dermatologic disease either cleared completely or markedly improved in 34/35 (97%). Comparable responses were observed in 31/35 (89%) patients treated with desoximetasone ointment 0.25%. Local tolerance to both study medications was excellent; no adverse reactions occurred. Plasma cortisol reduction occurred in few patients (4 resp. 3 patients each group), however this effect was only transient and reversible.

Adolescent↗
PubMed1984

[Therapeutic possibilities in condylomata acuminata].

This article deals with surgical as well as with conservative treatment of condylomata acuminata, e.g. 10% podophyllin in liquid paraffin. Both methods are equally successful and may be combined in special cases.

Combined Modality Therapy↗
PubMed1984

Non-traumatic removal of the nail and simultaneous treatment of onychomycosis.

There are no doubt a great many therapeutic recommendations for the treatment of onychomycoses. However, as so often, it soon becomes evident that the number of therapeutic regimens appear to indicate a wide range of therapeutic possibilities, but the rates of cure actually achieved are in complete contrast to these. The prerequisite for treatment is the identification of the causative fungi on direct microscopic examination and in culture to avoid the use of antifungals in changes of the nails other than onychomycoses. Another very important prerequisite for systematic treatment is the removal of as much fungus-infected nail material as possible, or else bioavailability at the site of infection cannot, or only hardly, be guaranteed. In our investigations into the treatment of onychomycosis we studied the use of bifonazole (1%)-urea ointment and the therapeutic possibilities in connection with its application.

Antifungal Agents↗
PubMed1983

[Therapy of erythrosquamous dermatoses. Betamethasone dipropionate plus salicylic acid in comparison with betamethasone dipropionate solution].

Efficacy and tolerance of an alcoholic solution containing 0.64 mg betamethasone-dipropionate plus 20 mg salicylic acid (Diprosalic Solution) were compared with an alcoholic solution containing 0,64 mg betamethasone-dipropionate in a 3 week double blind study in 100 patients with psoriasis and other steroid-responsive dermatoses of dry nature, comprising scalp and other hairy and non-hairy areas of the body. This double blind study was followed by a 3 week open study in another 100 patients with similar diagnosis, using Diprosalic Solution only. Although the therapeutic results of the double blind study showed no significant differences between both treatment groups, distinct advantages of the drug containing salicylic acid could be clearly demonstrated, such as: 1. More rapid onset of action, 2. rapid clearing of scaling, pruritus and inflammation, 3. these advantages are in compliance with the fact that topically applied salicylic acid softens keratin, loosens cornified epithelium and desquamates the epidermis, making the underlying layers more accessible to the antiinflammatory steroid.

Administration, Topical↗
PubMed1979

[Predisposing factors in candidiasis].

The Candida mycosis is an infection by Candida albicans and other Candida species. This disease is not initiated by contact of Candida with the normal skin and mucous membranes or by invasion into the healthy host. On the contrary the presence of predisposing factors is important to Candida mycosis. These predisposing factors are considered as an impairment of local and/or general immunity and transform the opportunistically pathogenic character of the fungus into a parasitic one. Thus the host's defence mechanisms alone favour the development of Candida mycosis.

Bacterial Infections↗