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Biomedical subjects

S Ochs

Publications and source records attributed to S Ochs.

At least 73 records · Page 4Linked to original sources
PubMed1972

Rate of fast axoplasmic transport in mammalian nerve fibres.

1. Fast axoplasmic transport in mammalian nerve fibres was determined by the presence of a crest of activity in the sciatic nerve after injection of [(3)H]leucine into the L7 dorsal root ganglion or the L7 motoneurone region in the ventral horn region of the spinal cord. After incorporation into proteins by the cell bodies, a rate of transport close to 410 mm/day was found for cat sensory nerves. A closely similar rate was found in the motor and sensory sciatic nerve fibres of the monkey, dog, rabbit, goat and rat. In the longer nerves where longer downflow times were possible, there was no decrement of rate with distance, or presence of later appearing crests of activity indicative of multiple fast transport systems.2. The rate of fast transport found in the long L7 dorsal roots of the rhesus monkey was the same as that in the corresponding length of sciatic nerve and the same fast rate was shown by the crest of activity ascending in the dorsal columns of the spinal cord.3. Labelled activity was found present inside myelinated nerve fibres ranging in diameter from 3 to 23 mum in nerve segments taken at the forward part of the crest suggesting that the rate of fast axoplasmic transport is independent of fibre diameter.

Animals↗
PubMed1971

Local supply of energy to the fast axoplasmic transport mechanism.

Local anoxia of a small region of cat sciatic nerves causes a block of fast axoplasmic transport in vitro. Activity becomes dammed up at the face of the anoxic region, and falls off rapidly distally just inside the anoxic region. Such blocks were reversible if they were removed within 1 hr. Earlier studies had given evidence that fast axoplasmic transport is closely dependent on ATP derived from oxidative metabolism. The present results indicate that ATP is required all along the length of the nerve fiber to supply a hypothesized "transporting filament" mechanism of fast transport.

Adenosine Triphosphate↗