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Biomedical subjects

S P Lebedev

Publications and source records attributed to S P Lebedev.

At least 19 recordsLinked to original sources
PubMed1990

[Campylobacter pylori in patients with liver cirrhosis of different etiologies].

The role of Campylobacter pylori (CP) in the development of chronic gastritis and ulcero-erosive lesions in 76 patients with liver cirrhosis of various etiology is studied. The incidence of CP bacteriosis in liver cirrhosis was 47.3% and the incidence of CP detection by bacteriological methods was not dependent on the cirrhosis etiology. The incidence of CP detection depended on the chronic gastritis activity and the presence of ulcero-erosive lesions. Hypochlorhydria is one of the important factors favouring CP colonization in liver cirrhosis. DE-NOL can be recommended for the treatment of chronic active gastritis and ulcero-erosive lesions.

Adolescent↗
PubMed1990

[Diffuse pulmonary leiomyomatosis].

A rare case of a diffuse pulmonary leiomyomatosis in a female aged 38 is described. Alveolar proteinosis was suspected clinically. Diagnosis of the diffuse pulmonary leiomyomatosis was established at the autopsy basing on the pattern or morphological changes.

Adult↗
PubMed1989

[Hepatogenic ulcer (various aspects of its pathogenesis)].

Functional and morphological state of the stomach and duodenum was studied in 98 patients with liver cirrhosis. Hepatogenous ulcer was revealed in 21.7 per cent of the patients with alcoholic and in 25 per cent of those with viral liver cirrhosis. A specific feature of the condition was the development of ulcer in reduced gastric acid production and its asymptomatic course. The incidence of gastric and duodenal affections in liver cirrhosis was significantly higher in pronounced portal hypertension. Study of the portal blood flow with Doppler ultrasonography can reveal the risk group (patients with pronounced portal hypertension) which has high probability of the development of erosion-ulcerous lesions. These patients require obligatory medical checkups with gastric and duodenal endoscopy 2-3 times a year.

Adult↗
PubMed1986

[Clinico-morphological characteristics and prognosis of glomerulonephritis in chronic alcoholism].

The paper is concerned with the results of a long-term study with clinicomorphological correlations of 86 patients with alcoholic glomerulonephritis (GN), i. e. 12% of all morphologically verified cases of primary GN. GN clinical features in alcoholism were painless microhematuria, moderate hyperuricemia, frequent combination with the alcoholic involvement of the other organs and the elevated blood serum IgA level. An important diagnostic sign in alcoholic GN was a positive clinicolaboratory time course in abstinence. A morphological study showed prevalence of mesangioproliferative GN with deposits containing IgA and C3, often with a noticeable tubulointerstitial component and fibroplastic glomerular transformation. The accumulation of podocytes and nephrocytes of intermediate filaments in the cytoplasm should be regarded as an important morphological feature of alcoholic GN. An unfavorable course of alcoholic GN with an outcome into chronic renal failure was observed in 35% of the patients. Prognostically unfavorable signs were the age under 40, the presence of considerable proteinuria (over 1 g/day), the nephrotic syndrome, the detection of the glomerular immune complexes, a tubulointerstitial component, fibroplastic transformation of mesangioproliferative nephritis as well as the detection of mesangiocapillary, diffuse fibroplastic and extracapillary nephritis.

Adult↗
PubMed1986

[Morphology and various problems of the pathogenesis of alcoholic microangiopathy].

Alcoholic microangiopathy was studied on the biopsy material from kidneys, skin and salivary glands of alcoholic patients by means of histochemical, immunohistochemical and electron-microscopic methods. Its formation is mainly caused by the direct action of ethanol on microcirculatory vessels. Alcohol-induced microangiopathy is morphologically manifested by the accumulation of intermediate filaments in the cytoplasm of endotheliocytes and perivascular infiltrate macrophages. The expression of pathological changes in the cytoskeleton is reduced due to the abstinence from alcohol. Glomerulonephritis in alcoholic patients, that can be considered as a peculiar manifestation of alcoholic microangiopathy, is immunocomplex with predominance in these immune complexes of IgA in combination with IgG and C3 complement fraction. Morphologically it is characterized by the accumulation of intermediate filaments in the cytoplasm of podocytes, mesangiocytes, nephrocytes and some endothelial cells, as well as early and quick formation of fibroplastic transformation and cirrhosis of the kidney.

Adult↗
PubMed1985

[Clinical morphology of alcoholism].

Separation of the alcoholic disease into a special nosological entity is founded on the basis of a clinico-morphological analysis. It is suggested to distinguish hepatic, gastric, pancreatic, cardiac, pulmonary and renal clinico-anatomical forms of the alcoholic disease that are most frequently observed in the therapeutic clinics. The most characteristic signs of the ethanol effect ("morphological markers") are as a rule observed in the exacerbation of the disease. They are as follows: alcoholic hyalin in hepatocytes and accumulation of intermediate filaments in the epithelial and mesenchymal cells. Pathology of the cytoskeleton is a morphological expression of the affected protein metabolism. Apart from the disturbance of the protein metabolism, the metabolism of lipids is damaged as well, this being manifested in the accumulation of fat inclusions in the cytoplasm of the different organ cells. Leucocytes and macrophages of the exudate in the alcoholic disease possess the signs of the functional insufficiency thus confirming the state of the immunodeficiency in alcoholics.

Acute Disease↗
PubMed1985

[Granulomatous hepatitis].

The diagnosis of granulomatous hepatitis was made on the basis of granulomas observed in the liver biopsies from 64 patients. It is shown that the macrophagal granulomas are, as a rule, localized inside the lobules, do not possess the characteristic features and represent the morphological manifestations of a non-specific reactive hepatitis. At the same time macrophagal granulomas may be a stage in the formation of the epithelioid-cell granulomas. The latter reflect the long persistence of the antigen in the liver macrophages. In certain cases the epithelioid-cell granulomas acquire specific features and these allow one, when analysing the liver biopsies, to confirm or to suggest the etiology of the disease (sarcoidosis, tuberculosis). An essential help in establishing the etiology of granulomatous hepatitis comes from the repeated clinical examination of patients and repeated liver punctures.

Chronic Disease↗
PubMed1984

[Alcoholic hyalin and interstitial filaments as markers of alcoholic damage of internal organs].

Biopsies of the liver, stomach, pancreas, small salivary glands, lung of patients with chronic alcoholism were studied morphologically including ultrastructural analysis. The formation of fibrillar alcoholic hyalin in hepatocytes is the most characteristic ultrastructural feature of the liver alcoholic damage. Accumulation of intermediate filaments in the epithelial cells of the stomach, pancreas, small salivary glands, stomach macrophages is a characteristic sign of the alcoholic damage to these organs. This disturbance of the structural organization of the cytoskeleton seems to reflect secretory insufficiency of the epithelium and failure of macrophagal function.

Alcoholism↗
PubMed1984

[Morphology and morphogenesis of chronic gastritis in patients with alcoholism].

The characteristics of all types of chronic gastritis in patients with chronic alcoholism is given. Alterations of the stomach mucous membrane in alcoholism of different duration are described in detail. The intermediate type filaments in the surface epithelium, cells of glands and macrophages are found which is reported to be a morphological manifestation of alcoholism.

Adult↗
PubMed1982

[Intermediate filaments in the lung macrophages and endothelial cells in chronic alcoholism and suppurative-destructive lung diseases].

Accumulation of intermediate filaments in lung macrophages and endotheliocytes has been found in patients with chronic alcoholism and purulent destructive pulmonary diseases. Excess accumulation of cytoskeletal elements reflects cell dystrophy. The authors believe that impairment of macrophage function may favour the lingering of the suppurative process.

Alcoholism↗