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Biomedical subjects

S P Lebedev

Publications and source records attributed to S P Lebedev.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Morphology and pathogenesis of visceral manifestations of chronic alcoholism].

Chronic alcoholism is accompanied by systemic involvement of the internal organs. Clinico-morphological forms of chronic alcoholism are distinguished on the basis of the prevailing organ pathology, Morphological data are presented, and pathogenesis of the lesions of the liver, heart, pancreas, and kidneys in patients with chronic alcoholism is analysed. The hepatic form may present alcoholic dystrophy, hepatitis or cirrhosis which are stages of progressing hepatopathy. The toxic and metabolic effect of ethanol is important in the pathogenesis of liver lesion. The cardiac form is characterized by the development of alcoholic myocardiodystrophy. In addition to the toxic influence of ethanol, hormonal and electrolyte changes and microcirculatory disorders play a role in its pathogenesis. Chronic calcifying pancreatitis in chronic alcoholism is associated with the effect of ethanol on the mediatory system. The renal form any present necronephrosis, hepatorenal syndrome, glomerulonephritis or pyelonephritis. Their pathogenesis is determined by toxicity of ethanol, circulation of immune complexes in the blood, or immunosuppression.

Alcoholism↗
PubMed1980

[Diagnosis of viral liver cirrhosis in the practice of the pathologist].

An autopsy observation of viral cirrhosis of the liver is presented. Along with the clinical data, morphological diagnosis of viral cirrhosis of the liver one should take into account not only the nature of cirrhosis (macronodular surface, multilobular structure of regenerative nodes, wide fibrous septae and lymphohistiocyte infiltration, Councilman bodies, "frosted vitreous" hepatocytes, mature lipofuscin in hepatocytes) but also the possibility of detecting HBsAg in paraffin sections of the liver stained with orseine and aldehydethionine.

Adult↗
PubMed1980

[Experience in conducting a test exam in pathological anatomy].

Taking into consideration the experience in examinations at medical schools of various countries and personal experience in conducting examinations by the test method, the authors believe that the test method should be used at examinations in order to assess the knowledge of the students objectively, particularly, when the number of students to be examined is large. This method is sufficiently effective, time saving, permits one to correlate the results of teaching with the tasks set, to detect defects in studying some parts of the course and to correct the process of teaching. It should be used only partially, however, to examine the knowledge of the theoretical part of the course, whereas the practical part should be presented at oral exams allowing personal contacts of the teachers and the students.

Educational Measurement↗
PubMed1979

[Hepatitis and cirrhosis of the liver (classification, morphology and morphological differential diagnosis].

The current classification of hepatitis and hepatocirrhosis is evaluated on the basis of the literature analysis and the study of the author's own material. Morphological criteria for differential diagnosis of liver diseases of viral and alcohol etiology are proposed. A clinical pathologist examining a liver biopsy may confirm or establish the etiology of the disease, determine the degree of activity and compensation of the process. An analysis of these criteria helps a clinician to choose the method of treatment and to determine the prognosis of the disease.

Chemical and Drug Induced Liver Injury↗
PubMed1978

[Diagnosis of alcoholic liver cirrhosis during autopsy].

Approaches for the diagnosis of alcoholic cirrhosis of the liver at the dissecting table are given on the basis of the analysis of autopsy materials and liver biopsies. The etiological verification of cirrhosis is based on the peculiar morphological lesions of the liver and other organs. The liver is enlarged, its surface micronodal; histologically, an attack of acute alcoholic hepatitis is found not infrequently: necroses of hepatocytes, predominantly neutrophilic infiltration of the stroma and necrotic zones, alcoholic hyalin. Due to autolysis, alcoholic hyalin in the autopsy material changes somehow and is hardly detectable. A combination of alcoholic cirrhosis of the liver with alcoholic cardiopathy and/or chronic calcifying pancreatitis is typical.

Autopsy↗
PubMed1978

[Morphological variants of alcoholic hyalin and possible ways of its evolution].

Possible ways of alcohol hyalin evolution were studied by repeated electron microscopic examinations of the livers of 2 patients with acute alcoholic hepatitis Four types of ultrastructure of alcoholic hyalin were found: parallely oriented fibrillae, randomly oriented fibrillae, fine granular and large granular (spotlike) substance. Examinations of the material from repeated biopsies showed fibrillar hyalin to be "young" and to turn into "old" hyalin of granular structure. The evolution of alcoholic hyalin from fibrillar to granular is accompanied by hepatocyte necrosis and leukotaxic effect.

Adult↗