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S P Lebedev

Publications and source records attributed to S P Lebedev.

47 records · Page 3Linked to original sources
PubMed1976

[The morphology and morphogenesis of alcoholic cirrhosis of the liver].

A total of 42 biopsy specimens of the liver (blind and spot) in 32 patients with alcoholic cirrhosis of the liver were investigated. Morphological, portal, postnecrotic, and mixed types of cirrhosis were established. The portal type of cirrhosis is most common. On the basis of repeated analyses of biopsy materials of the liver it may be assumed that the development of cirrhosis of the liver of alcoholic etiology is connected with multiple attacks of acute alcoholic hepatitis. Abstention from alcohol consumption resulted in stifestations of exacerbation of cirrhosis. On the other hand, continuation of alcohol consumption contributed to progressing of cirrhosis, which following several attacks of alcoholic hepatitis, may change its morphological type: portal cirrhosis "transforms" into the postnecrotic or mixed type. The data obtained clarified the role of ethanol in progressing alcoholic cirrhosis of the liver, which according to the initial mecranisms of its development in postnecrotic, since every attack of acute alcoholic hepatitis is accompanied by coagulative (fields of alcoholic hyaline, or Mallory's bodies), or by colliquative (balloon dystrophy) necrosis of hepacytes.

Acute Disease↗
PubMed1975

[Alcoholic lesions of the liver (morphology and several questions concerning pathogenesis)].

On the basis of morphological studies of 130 puncture material of the liver in 100 patients with chronic alcoholism the three morphological forms of its lesion were identified: dystrophic changes in hepacytes; alcoholic hepatitis (acute and chronic); cirrhosis of the liver. It is suggested that the morphological forms mentioned above represent the stages of one process--developing alcoholic hepatopathy. Progressing of the process in the liver in chronic alcoholism is connected with necroses of hepacytes as a result of toxic effect of alcohol with a subsequent reaction of the cells of the portal stroma and sinusoids. Gravity of lesions of the liver depends largerly on individual sensitivity to alcohol, one of the main factor of which may be the capacity of the liver to reproduce ADG.

Acute Disease↗