PubMed Health⌕ Search

Biomedical subjects

S Perl

Publications and source records attributed to S Perl.

At least 55 records · Page 3Linked to original sources
PubMed1999

Nine cases of idiopathic toxic epidermal necrolysis in cattle in Israel.

Nine sporadic cases of apparent toxic epidermal necrolysis in nine cattle herds in Israel are presented. The clinical symptoms were characterized by full-thickness epidermal exfoliation. No underlying disease or drug administration could be detected in the affected animals, and so all cases were classified as idiopathic. Recovery was noted in all affected animals. The clinical and histological findings are discussed in the light of the pertinent literature.

Actinomyces↗
PubMed1999

A generalized staphylococcal scalded skin-like disease in lambs.

An idiopathic disease involving skin and kidneys was seen in two Merino lambs from the same herd. A generalized skin exfoliation in association with acute renal failure were the most prominent clinical features. The condition resembled staphylococcal scalded-skin syndrome of man, and pure cultures of Staphylococcus aureus were isolated from the lesion. Acute renal failure was diagnosed by clinical, biochemical and histological criteria, and necropsy.

Acute Kidney Injury↗
PubMed1999

Isolation of Corynebacterium pilosum and Actinomyces pyogenes from cystitis and vulvovaginitis infection in a 2-month-old female calf.

Cystitis and vulvovaginitits, due to Corynebacterium pilosum and Actinomyces pyogenes infection in a 2-month-old female calf, is described. The prominent clinical signs were urinary incontinence, adherence of triple phosphate crystals to the vulvar hair and ulceration on the vulva, the ventral side of the tail skin and the perineum. Only a mild inflammation of the bladder mucosa and submucosa was seen on histological examination.

Actinomyces↗
PubMed1999

Late onset of cerebellar abiotrophy in a Siamese cat.

A late onset of cerebellar degeneration was diagnosed in a one-and-a-half-year-old Siamese cat. The animal had been presented with mild ataxia involving all four limbs. Over the following two years, the signs gradually progressed to severe incoordination, a frequent tendency to fall and a head tremor. The neurological signs were consistent with a diffuse cerebellar lesion and the cat was euthanased. Profound and diffuse Purkinje cell loss was found on histopathological examination, but no aetiological agent was detected.

Age of Onset↗
PubMed1999

Laminitis and dermatitis in heifers associated with excessive carbohydrate intake: skin lesions and biochemical findings.

The effects of a sudden addition of a large quantity of readily fermentable carbohydrate to the feed ration of pregnant heifers are described. Clinical and pathological changes caused by the resulting disease were confined to the digits and skin. The 4 acutely affected heifers were reluctant to get up or move (group II). They tended to lie down or stand with feet bunched together and the back arched, often shifting weight from limb to limb. They walked stiffly with great tenderness and pain in the digits. Extreme pain was noticed when the digits were examined. In 4 of 8 heifers, separation of the sole at the heel, with leakage of exudate, and under-running of the sole were observed. Necrotic dermatitis of the legs, alopecia and hyperkeratosis of the tail were noticed in all 8 heifers. Skin lesions appeared simultaneously. Four of the heifers (group I) recovered, and the other 4 (group II) were sent to slaughter. No post mortem examination was performed. The biochemical findings revealed a significantly higher concentration of total serum globulins and sodium, and increased activity, in CK, LDH and AST. A significantly decreasing pattern was noted in blood urea concentration, cholesterol, triglycerides, albumin and calcium. No significant differences among the various groups were found in the activities of amylase, GGT, and concentration of creatinine, total bilirubin, inorganic phosphorus, magnesium and potassium.

Animal Feed↗
PubMed1999

Case report: umbilical foreign-body granuloma in a lamb.

An unusual case of umbilical foreign-body granuloma in a 3-week old lamb is described. The most prominent clinical finding was a large fibrous mass which bulged above the surface, adjacent to the umbilicus. Histologically, plant material surrounded by histiocytes, plasma cells, giant cells and fibroblasts were seen.

Animals↗
PubMed1999

Case report: idiopathic toxic epidermal necrolysis in a one-week old calf.

A sporadic case of apparent toxic epidermal necrolysis in a one-week-old calf is presented. The clinical picture was characterized by full-thickness epidermal exfoliation. No underlying disease or drug administration could be detected in the affected animal, therefore, the case was classified as idiopathic. The clinical and histological findings are discussed in the light of the pertinent literature. Recovery was noted within three months.

Animals↗
PubMed1999

An apparently gluten-induced photosensitivity in horses.

Primary photosensitization was observed in 3 Appaloosa mares. The skin lesions were diffuse erythema followed by edema and subsequently weeping and finally dry gangrene and ulceration. The severe photosensitivity dermatitis was apparently induced by gluten ingestion. Resolution of lesions occurred after withdrawal of the suspected dairy concentrate feed and prevention of exposure to sunlight. Neither the ponies nor donkey, which were not fed with the suspected concentrate, exhibited similar skin lesions or other clinical abnormalities. Gluten metabolites may contain photodynamic agents that cause photosensitization in horses.

Animals↗
PubMed1998

Cutaneous neosporosis in a dog in Israel.

Cutaneous neosporosis manifested by pyogranulomatous ulcerative dermatitis was diagnosed in an 11-year-old male Boxer. Histology revealed numerous intralesional protozoal tachysoites within macrophages and neutrophils. Occasionally, tachysoites were observed within endothelial and epithelial cells. Infection with Neospora caninum was confirmed by avidin biotin complex immunohistochemistry using a Neospora-specific monoclonal antibody. Cutaneous neosporosis is rare and has only been previously described in three cases. This report represents the first case of canine neosporosis in Israel and the Middle East.

Animals↗
PubMed1998

Identification of a gene selectively expressed in the brain, which encodes a putative transmembrane protein and a soluble cytoplasmic isoform.

Subtractive cloning procedures led to the identification of a variety of transcripts expressed in mammalian brain. However, little is known about the encoded proteins and the regulation of gene expression. Here, we describe the isolation and characterisation of a single-copy gene (83.5) of 21.7 kb which is specifically expressed in porcine brain. In situ hybridisation and immunohistochemistry experiments showed a distinct pattern of gene expression in neuronal cell types in different parts of the brain. The gene contains two mini exons, confirming neural-specific expression. cDNA cloning experiments revealed two species of mRNA differing in their 5'-regions. These transcripts are generated by two distinct transcription start sites that are under the control of different potential promoter regions as shown by primer-extension experiments. The amino acid sequences of the deduced proteins predict that one mRNA species encodes a novel type-I transmembrane protein, whereas the other transcript encodes only a part of its cytoplasmic domain. In Western-blot experiments, we detected two proteins of the predicted size and cellular localisation in porcine brain. The precise function of these proteins remains to be determined. However, our findings suggest that they may be generated by alternative promoter usage, leading to the expression of a membrane protein and its truncated cytoplasmic isoform.

Amino Acid Sequence↗
PubMed1998

Clinical aspects of an outbreak of papillomatous digital dermatitis in a dairy cattle herd.

Digital skin lesions and lameness of several weeks duration, with a morbidity rate of 28.3%, was reported in a group of 60 Holstein-Israeli dairy cows in various stages of lactation. A clinical survey was performed to monitor recovery and to confirm eradication of bovine papillomatous digital dermatitis in the herd. The combined effects of intensive individual treatment of the 4 lame cattle with procaine penicillin and metronidazole, and subjecting all animals in the herd to a foot bath with a solution composed of formaldehyde and sodium hydroxide twice a week for 12 weeks, were found to achieve a dramatic positive response in all affected cows in the herd. During a 1-year follow-up period no recurrence and/or new cases have been diagnosed.

Animals↗
PubMed1998

Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism.

An unusual case of necrotic infection of the tongue and unilateral necrotic maxillar sinusitis, in a cow is reported. The prominent clinical findings were: a marked salivation, unilateral mucopurulent nasal discharge, diffuse necrotic lesions on the ventral side of the tongue and fetid breath. Clinico-pathological and pathological findings and abnormalities in the haemogram were probably caused by the toxins produced by the causative organism--Fusobacterium necrophorum like microorganism.

Animals↗
PubMed1998

Probable toxicosis in cattle in Israel caused by the oak Quercus calliprinos.

A probable outbreak of oak (Quercus calliprinos) toxicosis in a herd of beef cattle--heifers and first-calving cows--grazing in the Judean foothills of Israel is described. Toxicosis probably occurred because of the consumption of oak leaves and buds during a period of pasture scarcity without any feed supplementation. A progressive syndrome of wasting, dullness, anorexia, polyuria, nephrosis, constipation and recumbency, culminating in death, was seen. A high mortality rate of 83% (38/46 animals) was noted. The clinical-pathological findings revealed increases in blood urea, creatinine, aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), creatine kinase (CK), lactate dehydrogenase (LDH) and inorganic phosphorus. Decreases were found in alkaline phosphatase (ALP), total serum protein, albumin (ALB), triglyceride (TG), calcium (Ca), magnesium (Mg), sodium (Na) and chloride (CI). The main pathological findings were severe nephrosis, chronic interstitial nephritis, and occasional intestinal ulceration. On the basis of epidemiology, clinical signs, clinical-pathological and pathological findings and renal histology, a tentative diagnosis of oak toxicosis was made.

Animals↗
PubMed1997

Acute maduramicin toxicity in calves.

A herd of 277 beef-breed calves in three age groups was mistakenly given the poultry coccidiostat maduramicin in a total mixed ration. It caused an acute toxicosis in which sudden death was the sole clinical finding in most cases. One group of 212 calves aged five to eight months suffered a mortality of 51 per cent in eight days and a total mortality of 56 per cent during the 40 days in which mortality was recorded. Mortality of only 3 per cent was recorded in two other groups of calves aged nine to 16 months in eight days and a total mortality of 11 per cent over the 40-day period.

Age Factors↗
PubMed1997

Corynebacterium pseudotuberculosis infection in Israeli cattle: clinical and epidemiological studies.

Morbidity due to Corynebacterium pseudotuberculosis infection occurred in 29 dairy herds in Israel during 1989 to 1995. The disease occurred sporadically in 17 of the herds with a morbidity of up to 5 per cent, and was epidemic in 12, with a morbidity of 5 to 35 per cent. Cutaneous abscesses were diagnosed in 609 animals. Young cattle appeared to be less susceptible to the disease than older cows. Beef cattle herds were not affected. The disease appeared in the cutaneous form in 92.5 per cent of cases, the cutaneous and mastitic form in 5.9 per cent and the cutaneous and visceral form in 1.6 per cent. The cutaneous form appeared as deep subcutaneous abscesses on various parts of the body, with granulating ulcers exuding pus and blood. In 10 of the herds, C pseudotuberculosis was isolated from 33 mastitic cows which also had cutaneous lesions. The visceral form of the disease was detected when severely affected animals were slaughtered. In 23 of the herds, the disease occurred during the spring and summer dry season, from March to October; the highest prevalence was in the semi-arid Negev region. In 25 herds, the infection lasted for up to five months. The skin lesions on individual cows healed on average in 23.4 days, after either local or parenteral treatment. No significant difference was observed between the effect of systemic antibiotic treatment and local antiseptic treatment. One hundred and two (16.7 per cent) severely affected animals were culled. There was a decrease in milk production and large increases in somatic cell counts in the 12 herds in which the disease was epidemic. None of the strains of isolated C pseudotuberculosis reduced nitrate.

Animals↗