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Biomedical subjects

S Perl

Publications and source records attributed to S Perl.

At least 73 records · Page 4Linked to original sources
PubMed1997

Effects of low power laser-irradiation on differential blood count and body temperature in endotoxin-preimmunized rabbits.

Low power laser irradiation has been shown to have various immune-modulatory effects under in vitro conditions but little is known about such effects in animal models. Escherichia coli endotoxin-preimmunized rabbits were used to determine the influence of transcutaneously applied low power laser light on differential blood count and rectal temperature. After three initial immunizations animals were either boostered with 5 ng/kg of endotoxin or injected with pyrogen-free saline and subsequently underwent irradiation using two different wavelengths of red laser light and sham irradiation, respectively. Differential blood count of laser-treated animals was characterized by significantly higher lymphocyte values and lower neutrophil values at twenty hours (boostered rabbits) and twenty-three hours (non-boostered rabbits) after irradiation. Differential blood cell counts returned to baseline values within 23 hours in the boostered animals, whereas in the non-boostered rabbits lymphocytes showed a trend to further increase. Recording of rectal temperature revealed a further rise after laser application, changes being of greater magnitude and longer duration in the non-boostered animals. These results seem to indicate that a single low power laser irradiation can modulate immune-responses depending on the immunological status of the organism.

Animals↗
PubMed1997

Infertility in a cryptorchid bull: a case report.

A unilateral cryptorchid bull stationed in an AI center for 3.5 yr was studied to determine if maintaining such a bull could be justified. The following parameters were determined: quantity and quality of the ejaculates, basal and stimulated plasma testosterone concentrations, and the histology and testosterone concentrations of the testicles. The bull produced 232 ejaculates of which 125 (53.8%) were immediately discarded; the rest (107 ejaculations) were processed into pellets. Two of the 107 frozen ejaculates (2%) were found to be of excellent quality, 37 were (34.5%) of good quality, 45 were (42%) of satisfactory quality and 23 were (21.5%) of poor quality. Treatment of the calf with GnRH and hCG at 4 and 5 mo of age did not initiate the descent of the retained testicle. Testosterone concentrations measured at 14 mo, after hCG stimulus, indicated that the bull had impaired steroidogenesis when compared with 2 control bull calves. Post mortem examination revealed a small left testicle in the inguinal canal and a normal right testicle as well as normal secondary sex glands. During the breeding period at the AI center, the bull's peripheral testosterone concentrations decreased from 2.2 to 0.95 ng/ml Testosterone concentrations in the parenchymal tissue of the scrotal testicle were higher than in the parenchyma of the retained testicle (98.2 vs 53.9 ng/g). In contrast, the epididymis of the scrotal testicle had a lower testosterone concentration than the epididymis of the retained testicle (10.8 vs 33. 0 ng/g). On histological examination no spermatozoa were found in the retained testicle, the Sertoli cells showed fat degeneration, and fibrotic tissue surrounded the tubuli seminiferi. No pathological changes were found in the normal scrotal testicle. In conclusion, no justification was found for maintaining such a bull in the AI center for breeding purposes.

Journal Article↗
PubMed1997

An apparent flea-allergy dermatitis in kids and lambs.

Heavy infestation of lambs in two herds and kids in one herd with the cat flea, Ctenocephalides felis felis, accompanied by severe anaemia, eosinophilia and exudative dermatitis, is described. Flea infestation was more widespread during the summer months, when optimal climatic conditions for flea development prevail. The clinical and histological findings are discussed in the light of the pertinent literature. Recovery of the affected animals and normalization of the haematological values were observed after the insecticide treatment. Flea-allergic dermatitis is apparently the cause of the skin lesions in the lambs and kids.

Anemia↗
PubMed1997

Oral rabies vaccination of red foxes and golden jackals in Israel: preliminary bait evaluation.

Field trials were conducted in late April to early May of 1995 and 1996 in central Israel to assess the potential for controlling rabies in red foxes (Vulpes vulpes) and golden jackals (Canis aureus) by using vaccine-laden baits. Of the bait types which were field tested, polymer fish meal baits were selected as the most suitable for both species. Fish meal baits containing tetracycline hydrochloride, an oral biomarker, were distributed by four-wheel-drive vehicle at a density of approximately 30 baits/km2 in two test areas of 35 km2. Of the animals which were trapped and euthanized seven to ten days after treatment, 65% of foxes and 56% of jackals gave positive results when tested for the biomarker. These results indicate the potential effectiveness of oral rabies vaccination of these species in Israel and possibly elsewhere in the Middle East, where rabies is a problem in wild canids.

Administration, Oral↗
PubMed1997

Clinical and epizootiological study of a leptospirosis outbreak due to Leptospira canicola in a feedlot.

This report describes the epizootiology, clinical presentation, diagnosis and treatment of an outbreak of leptospirosis caused by Leptospira canicola in feedlot calves. The infection appeared to be of high morbidity with a cumulative clinical incidence of 15.6%, cumulative subclinical incidence of 39% and high mortality (8.3%). Clinical disease was diagnosed in 4-8-month-old calves, while subclinical infection occurred in 9-12-month-old calves. Subclinical infection was based on serological evidence only. The zoonotic aspects of the infection are emphasised.

Animal Feed↗
PubMed1996

Skin tumours in cattle and sheep after freeze- or heat-branding.

This article describes the occurrence of carcinogenic epidermal neoplasia (papillomas and squamous cell carcinoma) at the sites of tattooing with liquid nitrogen in dairy cattle, and squamous cell carcinoma at the sites of freeze- or heat-branding in beef cattle and sheep.

Animal Identification Systems↗
PubMed1996

Bullous pemphigoid induced by PUVA therapy.

An 80-year-old psoriatic patient developed a blistering eruption during oral PUVA therapy. The diagnosis of bullous pemphigoid (BP) was established by routine histopathology, which demonstrated subepidermal blistering, and direct immunofluorescence, which revealed linear deposits of IgG, IgM and C3 along the basement membrane zone. Indirect immunofluorescence using normal human split skin revealed binding of IgG antibodies to the epidermal side, thus confirming a subepidermal blistering disorder. These proteins were identified by the immunoblotting technique as BP antigens I and II. Clinically, the lesions could be reproduced by phototesting using topical 8-methoxypsoralen. Again, the histopathological and immunopathological findings were consistent with the diagnosis of PUVA-induced BP. To the best of our knowledge, this is the first report demonstrating psoriasis-associated BP, in which the clinical diagnosis of BP is confirmed by immunoblotting analysis. The exact role of UV light in precipitating bullous lesions, particularly the question whether UV light may represent an unspecific epidermal injury leading to further attraction of autoantibodies to the basement membrane zone, as suggested recently by an experimental study in rodents, remains to be clarified in future studies.

Aged↗
PubMed1996

The effect of feeding dried tomato vines to beef cattle.

Dried Tomato vines (DTV) are used as a feedstuff in some beef cattle in Israel, despite the literature citation that tomato vines contain potentially harmful steroid alkaloids. A small-scale feeding trial over 42 d examined possible deleterious effects of feeding DTV, compared with wheat straw, in beef cows. No differences in hematological values, serum parameters for body weight were seen between the 2 groups. Steroid alkaloid content of the DTV was not examined, but toxic levels of nitrates were found. The main practical hazard in feeding DTV would appear to be from their potentially high nitrate content.

Alkaloids↗
PubMed1995

Differentiating between Besnoitia besnoiti from cattle and Sarcocystis hoarensis from rodents.

To provide a biological basis for studies designed to establish the mode of transmission of the veterinary pathogen Besnoitia besnoiti, we compared salient features of this pathogen in cattle with those of Sarcocystis hoarensis in rodents. The cysts and cystozoites of these organisms can readily be distinguished morphologically. In contrast to S. hoarensis, which is well adapted to rodents, B. besnoiti fails to mature in jirds or mice and generally is lethal in jirds. Serological reagents discriminately detect these pathogens. B. besnoiti, therefore, can unambiguously be differentiated from S. hoarensis either by morphological or serological methods or on the basis of experimental comparisons of virulence in laboratory rodents.

Animals↗
PubMed1995

Progression from Goodpasture's disease to membranous glomerulonephritis.

An unusual case of a patient with Goodpasture's disease presenting with hemoptysis, severe iron deficiency anemia and microscopic hematuria and proteinuria is described. Both circulating and tissue anti-glomerular basement membrane (GBM) antibodies were present, and renal function remained normal throughout. Immunosuppressive therapy was given for subclinical pulmonary hemorrhage with successful resolution of anemia and disappearance of the circulating anti-GBM antibody. Nine months after presentation he developed nephrotic range proteinuria and a repeat renal biopsy revealed membranous glomerulonephritis with no evidence of his original disease. Both the Goodpasture's associated HLA-DR2 and the membranous associated HLA-DR3 class II antigens were present. The association of antibody mediated and immune complex glomerulonephritis is discussed. The simultaneous presence of HLA-DR2 and HLA-DR3 may predispose to this association.

Adult↗
PubMed1994

Adverse reactions in cattle to a capripox vaccine.

Capripox vaccine (strain 0240) caused severe generalised skin reactions in vaccinated dairy cattle in two herds, whereas beef cattle did not develop reactions. All the reacting animals developed lumpy skin disease-like lesions. The incidence of skin lesions in first-lactation cows in herd A was 22.9 per cent and in herd B 29.3 per cent, mainly in the post-calving period. In older cows, the incidence was 10 per cent in herd A and 12.4 per cent in herd B. In herd B the high-yielding lactating cows were the most severely affected. There was a decrease of 3.5 per cent in milk production in each herd over a period of 12 days, and six first calving animals (3.5 per cent) and six cows (1.5 per cent) were slaughtered. A capripox virus was isolated from the animals with severe lesions, and was also demonstrated by electron microscopy. The histopathological lesions were similar to those of lumpy skin disease. The extent of the lesions appeared to be stress-related and, to a lesser degree, correlated with age and breed.

Animals↗
PubMed1993

Comparison of narrow-band (311 nm) UVB and broad-band UVA after oral or bath-water 8-methoxypsoralen in the treatment of psoriasis.

BACKGROUND: There is a disparity between the absorption spectrum of 8-methoxypsoralen and the action spectrum for psoralen-sensitized erythema. In an action spectrum corrected for unsensitized reaction 313 and 365 nm have similar efficacies. OBJECTIVE: We evaluated the relative erythemogenic and antipsoriatic efficacy of narrow-band (311 nm) UVB with and without prior psoralen exposure. We also compared the effects of narrow-band UVB and broad-band UVA after oral and bath-water psoralen exposure. METHODS: Patients with psoriasis underwent half-side comparison studies. In one group the therapeutic efficacy of 311 nm UVB with and without oral psoralen was assessed. The second group received UVA and 311 nm UVB after oral psoralen. The third group was exposed to both radiation sources after bath-water exposure. RESULTS: The erythemogenic, pigmentogenic, and therapeutic efficacy of 311 nm was increased by oral psoralen. With systemic 8-methoxypsoralen, UVA was comparable to 311 nm UVB. After bath-water exposure, 311 nm was clearly superior to broad-band UVA. CONCLUSION: The efficacy of narrow-band 311 nm UVB can be enhanced by psoralen. Narrow-band 311 nm UVB is also effective after psoralen bath-water delivery.

Administration, Cutaneous↗
PubMed1992

Cardiomyopathy in cattle induced by residues of the coccidiostat maduramicin in poultry litter given as a feedstuff.

An experimental feeding trial was conducted in order to substantiate an hypothesis on the aetiology of a previously unrecorded cardiomyopathic syndrome in beef cattle in Israel. It was believed that residues of the ionophore maduramicin (Cygro; American Cyanamid) in poultry litter fed to cattle, after the maduramicin had been incorporated into broiler feed as a coccidiostat, were the cause of the cardiomyopathy. Three groups of 5 heifers were fed for several weeks (1) poultry litter from a field case, containing 4.8 ppm maduramicin; (2) poultry litter to which maduramicin was added to give a concentration of 12 ppm; (3) poultry litter with no maduramicin (control). Clinical, biochemical, necropsy and histopathological findings showed that maduramicin residues are cardiotoxic, even at the lower level of maduramicin fed, which is commonly encountered in poultry litter in Israel.

Animal Feed↗
PubMed1992

The evolution of neuroimaging of spinal cord injury patients over the last decade.

A review is presented concerning the development of new neuroimaging techniques in the last decade which have improved the diagnostic exploration of patients with spinal cord injuries, including studies of possible sequelae. A number of technical developments occurred in the 1980s, which have broadened the diagnostic capabilities of neuroimaging and made its investigative techniques more precise and less invasive. In a summarized way the new or upgraded modalities such as magnetic resonance imaging and angiography, computed tomography and ultrasound, are considered here with regard to the effect that they have had on the clinical management of patients with a traumatized spinal cord.

Diagnostic Imaging↗
PubMed1992

Current advances in magnetic resonance imaging (MRI) in spinal cord trauma: review article.

Magnetic resonance (MR) images of 87 patients who had sustained spinal cord injuries during the past 2 years, were analyzed and compared with the corresponding clinical, surgical, and in some cases pathological findings. In addition to the standard MR imaging techniques applied in the spinal cord injuries, we also introduced some recent MRI technical achievements which are anticipated to improve diagnostic accuracy and broaden clinical application of this modality with regard to the spinal cord trauma. The recent technical advancements that we used include image enhancement, fat tissue signal suppression, three-dimensional (3-D) imaging, and magnetic resonance angiography (MRA). The reviewed post traumatic changes disclosed in these MR images were classified in 4 categories: acute, subacute, chronic, and the injury's sequelae. The essential properties of the 4 new imaging advancements are considered in relationship to the gain in diagnostic improvement of MRI of the 4 phases of patients with spinal cord trauma.

Humans↗