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Biomedical subjects

S Perry

Publications and source records attributed to S Perry.

At least 181 records · Page 10Linked to original sources
PubMed1983

Selection criteria for individual dynamic psychotherapies.

The authors discuss the indications, contraindications, and enabling factors for four types of psychodynamically informed psychotherapy: supportive, focal, exploratory, and psychoanalysis. They outline the inherent and practical difficulties impeding psychotherapy outcome studies and summarize the limited research regarding psychodynamic treatments. The overall efficacy of psychotherapy has been documented, but to date studies have not demonstrated specific differential effectiveness and indications. The authors present the rationale for each of the four approaches and suggest ways of selecting among them.

Conflict, Psychological↗
PubMed1983

Cobalt, manganese and the calcium paradox.

The reperfusion of hearts with Ca2+-containing buffers after relatively short periods of Ca2+-free perfusion results in tissue damage, Ca2+ overload, loss of mechanical function and displacement of intracellular components into the extracellular phase. Using isolated, spontaneously beating Langendorff perfused rat hearts we have investigated whether Mn2+ and Co2+ exert a dose dependent inhibitory effect on this gain in Ca2+ and loss of intracellular constituents (assayed as myoglobin). We have also determined if the timing of the addition of Co2+ or Mn2+ is critical, and whether their protective effect is Ca2+-sensitive. When added only at Ca2+ repletion neither Co2+ nor Mn2+ provided protection. When present during the entire period of Ca2+ depletion and repletion, Mn2+ (005 to 4.0 mM) and Co2+ (0.1 to 4.0 mM) exerted a dose-dependent protective effect, indicted by a reduced and delayed onset of myoglobin release, a reduced gain in Ca2+, and an improved recovery of mechanical function. This protection was proportionally diminished if the cations were added late during the 10 min period of Ca2+ depletion and further reduced if after their late addition, Mn2+-free or Co2+-free Ca2+ repletion buffer was used. Mn2+ was more effective than Co2+, and decreasing the Ca2+ content of the perfusion buffer from 2.5 to 1.3 mmol.1-1 shifted the dose-response curve for this protection to the left. These results are discussed in terms of the possible mechanisms involved in the dose and time dependent protective effect of Mn2+ and Co2+.

Animals↗
PubMed1983

Testicular torsion in the older patient.

A 40-year-old man presented with severe right-sided scrotal pain and was proven to have a 720-degree right testicular torsion. Fewer than 50 documented cases of testicular torsion have been reported in men over the age of thirty. The anatomical predisposition for torsion generally selects these individuals early in life. Rapid diagnosis allowed for surgical correction and testicular salvage. We outline an expedient diagnostic approach for these difficult cases with use of the Doppler ultrasound and the technetium (99mTc) testicular scan.

Adult↗
PubMed1983

Effects of subarachnoid haemorrhage on intracranial prostaglandins.

Prostaglandins E2, F2 alpha, 6 oxo F1 alpha and thromboxane B2 increased in cisternal CSF following mock subarachnoid haemorrhage in dogs, particularly PGE2 (X25.5). Concentrations were increased also in lumbar CSF of five patients some 8 days after subarachnoid haemorrhage. Subarachnoid haemorrhage did not alter the production of prostaglandins by dog whole cortex or choroid plexuses in vitro, but production by pooled dissected cerebral arteries of PGE2 was increased and of 6 oxo F1 alpha was decreased. Intravenous indomethacin decreased prostaglandin production by cerebral tissues, and caused a marked decrease in the prostacyclin metabolite in CSF. The implications of our findings for the aetiology of cerebral vasospasm are discussed.

6-Ketoprostaglandin F1 alpha↗
PubMed1983

Human papillomavirus: detection of viral DNA sequences and evidence for molecular heterogeneity in metaplasias and dysplasias of the uterine cervix.

Colposcopic-directed biopsies of the uterine cervix from 22 patients were analyzed for the presence of human papillomavirus (HPV) DNA and structural antigens. 11 of the biopsies were classified microscopically as mild dysplasia, 3 as moderate dysplasia, 1 as severe dysplasia, and 7 as squamous metaplasia. Nonstringent hybridization with a bovine papillomavirus type 1 DNA probe and immunocytochemical analysis with an antiserum against papillomavirus genus-specific structural antigens were performed on all specimens. Of the 11 mild dysplasias, both HPV DNA and structural antigens were detected in 5, only HPV antigens in 3, only HPV DNA in 1, and neither DNA nor structural antigens in 2. Both HPV DNA and structural antigens were present in the 3 cases of moderate dysplasia. Only HPV DNA sequences were detected in the single case of severe dysplasia. HPV DNA was detected in 2 cases of squamous metaplasia. The 5 remaining cervical biopsies showing squamous metaplasia, tissue from 3 placentas, and 6 cervical carcinomas were negative for HPV DNA and structural antigens. Restriction enzyme cleavage patterns of HPV DNA in the dysplasias suggested that there are multiple virus types or subtypes associated with cervical dysplasia. Stringent hybridization with a HPV type 11 (HPV-11) probe revealed that only 1 of 10 dysplasias contained sequences with homology to the probe. Of the remaining 9 dysplasias, 5 contained HPV sequences detected under nonstringent hybridization. 2 of 4 squamous metaplasias contained viral sequences which hybridized to the HPV-11 probe as well as 1 of 6 cervical carcinomas.

Adolescent↗
PubMed1983

Transference interpretations in focal therapy.

There are three contradictory positions regarding the usefulness of transference interpretations in focal therapy: they are 1) indispensable, 2) to be avoided, or 3) not important compared with nonspecific therapeutic factors. After a review of the rationale and the uncompelling research supporting each position, the authors suggest tentative indications for transference interpretation in focal therapy and illustrate these with two cases.

Adult↗
PubMed1982

National Center for Health Care Technology assessment of therapeutic apheresis for rheumatoid arthritis, 1981.

The National Center for Health Care Technology coordinated the Public Health Service's assessment of therapeutic apheresis for rheumatoid arthritis in response to the Health Care Financing Administration's request for advice regarding Medicare coverage of this rapidly emerging technology. The information considered included reports available in the medical literature (as of early 1981), advice from the National Institutes of Health and Food and Drug Administration, advice from the appropriate medical societies, as well as information submitted by interested parties in response to a notice published in the Federal Register announcing the assessment. Synthesis of this information provided the basis for concluding that therapeutic apheresis for rheumatoid arthritis was considered experimental with the possible exception of treatment for life-threatening complications such as vasculitis, cryoglobulinemia, or hyperviscosity syndrome.

Arthritis, Rheumatoid↗
PubMed1982

Papillomavirus infection of the cervix I. Correlation of histology with viral structural antigens and DNA sequences.

Eight cervical biopsies showing mild dysplasia and one showing squamous metaplasia were studied for the presence of papillomavirus (PV) antigens using an immunoperoxidase method having immunospecificity against the genus-specific (common) structural antigen(s) and for PV-specific DNA sequences by molecular hybridization under nonstrigent conditions. Of the eight cases showing mild dysplasia, both PV antigens and PV DNA sequences were detected in five, PV antigens only in one, and PV DNA sequences only in one; viral antigens and DNA sequences were not detected in the remaining lesion. A characteristic cellular atypia (PV-induced atypia) was present in the superficial and intermediate layers of the epithelium in the six cases positive for viral antigens, and a proliferation of basal and parabasal cells (PV-induced hyperplasia) occurred in five of these. PV structural antigens were localized within nuclei of some of the cells displaying atypia but not in the proliferating cells. The PV-specific DNA sequences in all six cases had the properties of unintegrated PV-DNA. In view of the demonstration of both PV antigens and DNA sequences in this distinctive lesion (PV-induced atypia and/or hyperplasia), traditionally regarded as a form of dysplasia, it is proposed that this lesion be referred to as "papillomavirus infection of the cervix."

Animals↗
PubMed1981

The scientific basis for coverage decisions by third-party payers.

Each third-party health payer has its own method of determining which medical services should be covered. The new National Center for Health Care Technology (NCHCT) is charged with evaluating the medical and scientific basis for Medicare coverage of various tests and procedures used in the practice of medicine. Many of the important issues involved in performing these evaluations and the NCHCT approach are described in this article.

Cost-Benefit Analysis↗