PubMed Health⌕ Search

Biomedical subjects

S R Pal

Publications and source records attributed to S R Pal.

52 records · Page 3Linked to original sources

Respiratory syncytial virus-specific RNA synthesis in primary monkey kidney cell cultures.

Primary rhesus monkey kidney (MK) cell cultures were inoculated with respiratory syncytial virus and treated or untreated with actinomycin D before pulse labeling with uridine-5-3H. The virus-specific RNA synthesis was noted at its peak in the nucleoplasm and possibly less so in the cytoplasm of infected cells. At 48 and 72 hours post-inoculation (p.i.), small fractions of available cells were synthesising virus-specific RNA with labeling index of 15% and 18% respectively. By 48 hours p.i. syncytia started appearing and a higher grain count in the cytoplasm of actinomycin D-treated infected cells was noted.

Animals↗

Hepatitis B virus infection in northern India. Prevalence, subtypes, and seasonal variation.

Previous reports from India have been limited to the incidences of hepatitis B antigen (HB Ag) in health and disease. This paper reports on a study undertaken over the last two years to determine the incidence of hepatitis B virus infection, the serotypes prevalent among apparently healthy individuals and patients with liver diseases, and the seasonal incidence of sporadic acute hepatitis in this geographic area. The incidences of infection in health and disease show an endemic pattern. The Y subtype predominates among healthy carriers and patients with chronic liver diseases, whereas the D subtype predominates in patients with acute hepatitis. The similarity of subtypes of HB Ag among the majority of healthy carriers and patients with chronic liver diseases suggests that the majority of asymptomatic carriers (subclinically infected) would develop chronic liver disease. The proportion of HB Ag-positive cases of acute hepatitis was significantly higher during the two summer seasons than during the two winter seasons; this could be due to more frequent transmission of the virus by the faecal/urinary-oral route and its activation during the summer months, especially in areas with poor hygienic conditions. The urinary/faecal excretion of virus could thus maintain the natural transmission of the virus in such an environment.

Adolescent↗