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Biomedical subjects

S R Pal

Publications and source records attributed to S R Pal.

At least 37 records · Page 2Linked to original sources
PubMed1980

Paralytic rabies: a clinico-pathological study.

Clinical and pathological features of 11 cases of paralytic rabies have been described, with a detailed study of the peripheral nerves. The mean incubation period was forty-nine days (range 7-90 days). The mean interval between the onset of symptoms and death was 8.4 days (range 7-11 days). A history of animal bite was available in 9 cases. Pain and paraesthesiae at the site of the bite, followed by paralysis, were the main presenting symptoms. Motor weakness and involvement of the respiratory muscles was present in all cases. Histopathological features in the spinal cord and brain were (i) an inflammatory cellular reaction, (ii) vascular changes and (iii) inclusion bodies. Pathological changes were more severe in the spinal cord and brain-stem than in the cerebral cortex. Peripheral nerves showed segmental demyelination and remyelination. Wallerian degeneration, myelinated fibre loss and axonal loss. The changes were of variable degree. In 9 nerves segmental demyelination was the primary lesion. Wallerian degeneration and segmental demyelination were seen in 6 peripheral nerves. All the spinal nerves showed evidence of Wallerian degeneration as well as segmental demyelination. It is suggested that some protein component of rabies virus may produce primary demyelination in peripheral nerves by a cross-antigenic action on myelin protein, but that the pathological features in the spinal cord and brain are due to virus infection per se.

Adolescent↗
PubMed1980

Multiple sclerosis in North-West India.

Fifty-four patients, with multiple sclerosis from North-West India are described. This included two pathologically proven cases of multiple sclerosis. Five patients conformed to the definition of neuromyelitis optica (Devic's syndrome). This study is in agreement with the other series reported from Asia regarding the special clinical features of multiple sclerosis described from this part of the world. There is more common occurrence of visual impairment at onset, predominant involvement of optic nerves and spinal cord and higher incidence of classical neuromyelitis optica. There is no relationship of any or all cerebro spinal fluid abnormalities with the type of multiple sclerosis, duration of an attack and disability, except for the possible relation between the type of colloidal gold reaction pattern and the type of multiple sclerosis.

Adolescent↗
PubMed1980

Rabies virus infection of a flying fox bat, Pteropus policephalus in Chandigarh, Northern India.

The present communication reports for the first time in South East Asia an active infection of frugivorous flying fox bat (Pteropus poliocephalus) with a virus belonging to the Rhabdo virus group -- a bat virus. Negri body like structures were demonstrated by Seller's stain and direct immunofluorescence in the brain and salivary gland of the dead bat. The virus was isolated after intracerebral inoculation of homogenate of the bat brain, salivary gland or brown fat separately in new born mice.

Animals↗