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Biomedical subjects

S Rössner

Publications and source records attributed to S Rössner.

At least 199 records · Page 11Linked to original sources
PubMed1990

In vivo subcutaneous adipose tissue glucose kinetics after glucose ingestion in obesity and fasting.

The kinetic pattern of subcutaneous adipose tissue extracellular glucose following glucose ingestion was investigated in vivo with a microdialysis technique in normal-weight (n = 21) and obese subjects (n = 18) before and after a 7-day fast (n = 9). A dialysis probe (4 x 0.5 mm) was implanted subcutaneously, and was continuously perfused (5 microliters/min). The tissue dialysate glucose concentration was determined in 15-min samples before and during a period of 180 min after a 75-g oral glucose load. A comparison was made between the tissue dialysate concentrations and the venous blood glucose levels. In all study groups the increase in subcutaneous tissue dialysate glucose following glucose ingestion paralleled that in blood, with a time-lag of up to 15 min. In the normal-weight subjects the maximum relative increase in abdominal adipose tissue dialysate glucose was 25% higher (p less than 0.005) than the corresponding blood glucose level, and the total relative glucose level (area under curve, AUC) in abdominal fat was 20% (p less than 0.01) higher than in blood. In contrast, the kinetics of gluteal subcutaneous tissue dialysate and blood glucose levels were similar. In the obese patients before the fasting period the maximum relative glucose level in abdominal fat was almost twice as high as in blood (p less than 0.005), and the total glucose level (AUC) was 50% higher than the blood glucose AUC (p less than 0.005). After the fast, on the other hand, almost identical relative dynamics of abdominal subcutaneous tissue and blood glucose levels were found.(ABSTRACT TRUNCATED AT 250 WORDS)

Abdomen↗
PubMed1990

Prevalence of obesity in Sweden: cross-sectional study of a representative adult population.

In order to facilitate research on body weight related diseases, and to plan suitable prevention and intervention programmes, data concerning the prevalence of overweight and obesity are required on a nationwide scale. In this study, data for weight and height from a representative sample (n = 14,549) of adult Swedes (16-84 years of age) were analysed. Data were obtained from the Study on Living Conditions conducted by Statistics Sweden, and body mass indices (BMI, kg m-2) were calculated from these interviews. They were then calibrated, since we had previously found that reported anthropometric measurements must be corrected so as to conform to recorded height and weight values, and we have developed equations accordingly. The overall mean BMI (+/- SE) was 24.02 +/- 0.99 kg m-2 for women and 24.56 +/- 0.88 kg m-2 for men. However, with regard to age, striking differences between the sexes were observed using this cross-sectional approach. Whereas in men there was a moderate increase in BMI with age, there was a sharp increase in women from 45-54 years onwards. If obesity is defined according to WHO recommendations (BMI for men greater than 30.0 kg m-2, and for women greater than 28.6 kg m-2), then 34.5% of all men in our sample were found to be overweight and 6.6% were found to be obese. The corresponding figures for women are 31.2% and 13.1%. Our data suggest that, on a nation-wide scale, overweight and obesity are common in men and women, but in women there is a marked increase from the menopause onward, for reasons that have yet to be clarified.

Adolescent↗
PubMed1990

Maternal body weight and relation to birth weight.

In The Stockholm Pregnancy and Weight Development Study the relationships between birth weight and maternal initial body weight as well as weight increase during pregnancy were analysed in 2,295 subjects. As expected, the most important predictor of birth weight was total maternal weight increase, followed by initial maternal body weight. However, in women with an initial BMI value above 24 kg/m2, birth weight did not increase significantly in tact with maternal weight. The frequency of cesarean sections, 12% overall, was not significantly increased with maternal body weight. These data show that birth weight increases with maternal weight only up to the upper normal body weight.

Birth Weight↗
PubMed1990

Quality of alternative medicine--complications and avoidable deaths.

Patients with diseases, known to respond well to treatment within the conventional medical system, may be adversely affected if treatment with alternative medicine is given instead. In order to analyse to what extent this may occur in Sweden, a mail survey was carried out. Two hundred and forty-two heads of departments of pediatrics, internal medicine, rheumatology, neurology and oncology were asked to supply case reports where such alternative treatment had resulted in either a delay of diagnosis of a disease, where effective therapy was available, or in substitution of effective conventional therapy with alternative medicine. Eighty-four out of 233 clinics reported 123 cases from the period 1984-1988, most of them from internal medicine. Six patients died following alternative treatment and 27 had to be treated in intensive care units after severe complications of alternative treatment. In most cases health resort managers had withdrawn effective medication or instituted vegetarian diets for patients with severe catabolic conditions, such as collagen diseases, renal insufficiency or inflammatory bowel disease. Twenty-three children had been treated by alternative medicine in violation of the Swedish law against quackery, but legal action had not been taken in any case. The study, which, by design, may only reveal the tip of an iceberg, suggests that apart from the well-known direct complications, associated with alternative treatment, such treatment may further prevent patients from obtaining.

Adolescent↗
PubMed1990

Effects of a high-protein meal (meat) and a high-carbohydrate meal (vegetarian) on satiety measured by automated computerized monitoring of subsequent food intake, motivation to eat and food preferences.

We have examined the effects on satiety of equicaloric meals with different protein and carbohydrate content. Twenty normal weight healthy women were served cooked lunch meals made of commonly used natural food items with either a high-protein (43 energy %) (a meat casserole) or a high-carbohydrate (69 energy %) (a vegetarian casserole) content in a counterbalanced repeated measures design. The subsequent ad libitum evening meal intake (4 h after lunch) was measured by a 'universal eating monitor' and subjective feelings of motivation to eat and food preferences were assessed repeatedly. At the subsequent evening meal subjects ate 12 per cent less (P less than 0.05) after the high-protein meal compared to the high-carbohydrate meal. There was no difference in motivation to eat between meals. This could partly be explained by a difference in palatability between the meals. The food-preference lists showed that before lunch there was relative preference for high-protein foods in favour of high-carbohydrate foods. After lunch either meal produced instead a relative 'aversion' for high-protein foods. This 'aversion' was greater after the high-protein lunch meal than after the high-carbohydrate lunch meal.

Adult↗
PubMed1990

Adipose tissue determinations in cadavers--a comparison between cross-sectional planimetry and computed tomography.

The adipose tissue surfaces in 11 slices (+/- 5 cm from the umbilicus) were compared in two cadavers using computed tomography (CT) versus planimetry of band-sawed slices of the corresponding sections. A very close correlation was found with partial correlations of around 0.90. Retroperitoneal fat formed a considerable proportion of the total adipose tissue surface in the slices. The results were similar whether fat was defined as -250 to -50, -190 to -30, or -140 to -40 Hounsfield units. These data indicate that CT measurements agree closely with a direct morphometric method and thus can be used as a 'gold standard' for future development. The fact that fat which is located extraperitoneally, but still intraabdominally, constitutes a significant proportion of the slice surface in the umbilical region indicates that data relating intraabdominal fat measurements to metabolic functions must be interpreted with caution.

Abdomen↗
PubMed1990

Maternal body weight development after pregnancy.

Body weight development during pregnancy was monitored for 2295 women, and up to 1 year post-partum for 1423 of them, at 14 maternity clinics throughout Stockholm. The objective was to find predictors for post-partum weight retention. The mean weight gain after 1 year post-partum compared with the pre-pregnancy body weight (delta-weight) was 1.5 +/- 3.6 kg (P less than 0.001). Of the group 30 per cent lost weight, 56 per cent gained 0 to less than 5 kg and 14 per cent gained greater than or equal to 5 kg. When this result was corrected for possible average underestimation of the self-reported pre-pregnancy weight and weight gain with age, the mean delta-weight was 0.5 kg. The factor with the highest correlation with delta-weight was pregnancy weight gain (r = 0.36, P less than 0.001). Very low r-values, although statistically significant, were obtained for the correlation between the delta-weight and lactation (r = -0.09, P less than 0.01) and age (r = 0.06, P less than 0.05). The delta-weight was not correlated with pre-pregnancy body weight or parity. Women with a delta-weight of greater than or equal to 5 kg had, on average, a higher pre-pregnancy body weight, but initially overweight women had a more variable weight development than lighter women. One in every four women with a weight retention of greater than or equal to 6 kg after a previous pregnancy experienced a high weight gain even after the present pregnancy. Women who stopped smoking had a significantly higher delta-weight than either smokers or non-smokers. Women in the age group greater than or equal to 36 years had a higher mean pre-pregnancy body weight than younger women, and in the age group 26-35 years the pre-pregnancy body weight was increased with increased parity. Thus, post-partum weight development is individual and of the factors studied here only high weight gain during pregnancy and smoking cessation can be considered as predictors for persistent weight gain after 1 year post-partum.

Adolescent↗
PubMed1990

[Fasting--wrong in obesity?].

Fasting has been advocated as an effective way to reduce body weight. However, few data support any long-term effect of this therapy. On the contrary, evidence is accumulating that the repeated weight loss and concomitant weight gain, typical of fasting in many individuals, will lead to a subsequently higher body weight. Each weight cycle seems to increase the risk of a higher waist/hip ratio, greater metabolic efficiency and a food preference towards fat. All these trends result in further problems associated with weight loss and a vicious circle is established.

Body Composition↗
PubMed1989

Intralipid removal from plasma of uraemic and intensive care patients.

The removal rates from plasma of Intralipid and (125)I-albumin, simultaneously injected i.v., were analyzed in 10 chronic renal failure (CRF) patients. The results were compared with 9 intensive care unit (ICU) patients and five healthy subjects as controls. The fractional removal rates of Intralipid (k2) were significantly lower for the CRF patients compared to both ICU patients and healthy subjects. The initial plasma concentration of Intralipid, calculated by extrapolation of the elimination curve back to zero-time (y0), showed significantly higher values for CRF patients and healthy subjects compared to ICU patients. Removal curves expressed as ratios between Intralipid and (125)I-albumin paralleled the elimination curves for Intralipid, which suggests that the slope of the curves depends on Intralipid removal and not on leakage of macromolecules from the circulation. The very low initial plasma concentration of Intralipid in the ICU patients cannot be explained by a hyperdynamic circulation, but may be attributed to a rapid first passage disappearance of Intralipid from plasma into tissues such as the pulmonary vasculature.

Journal Article↗