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Biomedical subjects

S Rössner

Publications and source records attributed to S Rössner.

At least 289 records · Page 16Linked to original sources
PubMed1980

Effects of ethinylestradiol/D-norgestrel combinations on serum lipoproteins.

Serum lipoproteins were analyzed in 33 young women (mean age 22 years) before and after two cycles of treatment with one of the following ethinylestradiol/d-noirgestrel combinations (microgram/microgram): 30/150, 50/150 and 50/250. A slight but significant weight increase of 1.2 akg was found only in the 509/150 group. All three hormone combinations had similar effects on the lipoproteins. Before treatment all subjects had normal lipoprotein concentrations. Whole serum triglyceride (TG) and cholesterol concentrations were not significantly affected. In the whole group the LDL-TG concentration increased from 0.24 to 0.33 mmol/l (p < 0.001) and HDL-cholesterol fell from 1.54 to 1.35 mmol/l (p < 0.001). Smokers tended to have lower HDL-cholesterol than non-smokers. It is possible that HDL reductions for longer periods of time may be one of the factors that promote the development of atherosclerotic manifestations in young women on oral contraceptives.

Adolescent↗
PubMed1980

Long term follow-up of serum lipoproteins after jejuno-ileal bypass surgery for massive obesity.

Serum lipoproteins were determined in grossly-obese patients 24 to 59 months after jejuno-ileal bypass surgery. Only minor further changes had occured compared to results obtained after about one year. The main findings were: hypertriglyceridaemia, if present, was normalised; LDL-cholesterol was reduced by about 40 per cent and HDL-cholesterol did not increase in spite of the VLDL-TG normalisation and mean weight losses of about 40 kg for males and 50 kg for females. It is possible that in obesity the well-known negative relationship between VLDL-TG and HDL-cholesterol is disturbed, and that the low HDL concentration represents a primary lipoprotein abnormality directly linked to obesity, rather than an association with the serum TG increase often found in obesity.

Adult↗
PubMed1979

Intralipid clearance and lipoprotein pattern in men with advanced alcoholic liver cirrhosis.

Twelve male patients with advanced alcoholic cirrhosis of the liver were found to have markedly low serum lipid and lipoprotein concentrations. Serum triglyceride and cholesterol concentrations were about 50% of matched control values. The very low density lipoprotein-triglyceride concentration was only one-third of control values and the cholesterol concentrations in very low density and low density lipoproteins were far below control values. The mean high density lipoprotein cholesterol concentration was not significantly decreased, but in three of 12 patients extremely low values were found. These findings may reflect a failure of lipoprotein synthesis secondary to a bad nutritional state and metabolic disturbances in this advanced stage of liver cirrhosis. By means of the intravenous fat tolerance test with Intralipid it could be shown that substantial amounts of triglycerides could be cleared from the plasma in these patients. However, studies on the long-term Intralipid clearance capacity have to be performed before any general recommendations about the inclusion of fat emulsions in parenteral nutrition of these patients can be made.

Aged↗
PubMed1979

Granulocyte functions during treatment of obesity.

Food deprivation is known to suppress antimicrobial defence under certain conditions. This potentially negative consequence of weight reduction treatment for obesity was studied in 11 obese patients who were treated with a mixed, balanced 600 kcal(2.5MJ)/day diet for 4 weeks. The mean body weight fell from 103 +/- 5 to 95 +/- 6 kg. The antimicrobial defence was studied before and during the diet period by analyses of polymorphonuclear granulocyte bactericidal capacity and adherence. No signs of impaired granulocyte function were found. The possibility remains that during prolonged treatment by semistarvation host defence may be impaired, especially in grossly obese patients whose antimicrobial defence may be already impaired before treatment.

Adult↗
PubMed1978

On the "rapid beta" (Rbeta) lipoprotein variant of human serum.

By visual inspection of agarose gel electrophoretograms of lipoproteins, a beta lipoprotein with increased mobility, here named "rapid beta" lipoprotein, has been observed. By objective measurements of the migration distances of the lipoprotein bands in 542 electrophoretograms by means of an exact ruler, this visual impression was objectively confirmed. In samples, classified by inspection as "rapid beta", the beta lipoprotein was found to have migrated approx. 20% further than in control samples. The "rapid beta" variant was initially detected in samples from grossly obese patients where it occurs frequently, but does not seem to be specific for any clinical abnormality.

Electrophoresis, Agar Gel↗
PubMed1978

Normal serum-cholesterol but low H.D.L.-cholesterol concentration in young patients with ischaemic cerebrovascular disease.

Serum-lipoproteins were determined in male and female patients aged under 55 who had survived an attack of ischaemic cerebrovascular disease (I.C.D.). The results were compared with findings in healthy controls. Total serum triglyceride and cholesterol concentrations were not increased. However, in the very-low-density lipoprotein fraction increased cholesterol concentrations were found, and the mean value of high-density-lipoprotein (H.D.L.) cholesterol in I.C.D. patients was 18% lower than in controls. Since a low H.D.L.-cholesterol concentration has been suggested as an independent strong risk factor, it is possible that the susceptibility of I.C.D. patients to atherosclerosis is the result of a low H.D.L. rather than hyperlipoproteinaemia.

Adult↗