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Biomedical subjects

S Raia

Publications and source records attributed to S Raia.

At least 37 records · Page 2Linked to original sources
PubMed1988

Anatomic resection of liver segments V and VI.

We describe a surgical technique that allows identification and severing at the hilum of the hepatic artery and portal vein branches, which perfuse only segments V and VI of the right lobe of the liver. This is a technique that makes possible an anatomic resection of those segments. The bile duct and hepatic vein branches are ligated only when the liver parenchyma is sectioned. The technique was used in three patients with liver tumors. No patient received blood transfusions, and no postoperative local complications were observed.

Hepatectomy↗
PubMed1986

Systemic surgical shunts and splenomegaly as causes of haemolysis in portal hypertension in mansonic schistosomiasis. Evaluation through serum levels of haptoglobin, hemopexin and bilirubins.

The haemolytic process in hepatosplenic schistosomiasis is often regarded as a result of splenomegaly that can be increased by spontaneous or surgical shunts. The importance of splenomegaly and/or shunt on the etiology of haemolysis was studied in a group of 74 patients with hepatosplenic schistosomiasis and portal hypertension. They were divided into 4 groups: Group I (22 cases) - pre-operative; Group II (15 cases) - classic splenorenal shunt; Group III (22 cases) - selective portal decompression and Group IV (15 cases) - azygoportal disconnection with splenectomy. The first group is characterized by the presence of splenomegaly and the absence of shunt; the second by the presence of shunt and absence of splenomegaly; the third, by the presence of both splenomegaly and shunt and the last by absence of both, shunt and splenomegaly. In all cases, the levels of sensitive markers of haemolysis, such as haptoglobin and hemopexin as well as non-conjugated and total bilirubins were determined. Biochemical and coagulation parameters, used to evaluate the hepatic function, were also studied. The data was initially analysed according to a factorial experiment of 2 and standard least squares techniques were used to evaluate the effects of splenomegaly, shunt and their interaction. The results showed that the shunts always provoked haemolysis, even in the absence of splenomegaly, but the presence of both, splenomegaly and shunt, always increased the process of haemolysis.

Adolescent↗
PubMed1981

Praziquantel in the treatment of the hepatosplenic form of Schistosomiasis mansoni.

UNLABELLED: 40 patients with the hepatosplenic form of schistosomiasis mansoni were selected for this study. Among 29 patients submitted to oral endoscopy there were 28 in whom oesophageal varices were demonstrated and 20 out of 21 patients who presented gastrointestinal haemorrhage had been operated on. All patients received a single oral dose of 40 mg/kg b.w. of 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (praziquantel, EMBAY 8440, Biltricide). Unwanted side effects were recorded when spontaneously reported. These were rather frequent but generally mild and disappeared within hours without additional medication. Comprehensive laboratory tests as well as ECG and EEG dit not show any significant changes. 27 patients were parasitologically followed up for 3-6 months; 26 of them were egg-negative. In the 18 patients who could be followed up for more than 6 months, the cure rate was 94.4%. CONCLUSION: praziquantel can be safely given also to patients with hepatosplenic complications.

Adolescent↗
PubMed1980

Intra-hepatic percutaneous deposition of radioactive xenon (133Xe) as a means of measuring hepatic blood flow.

Percutaneous deposition of radioactive xenon in the hepatic parenchyma is suggested as a technique for estimating the hepatic blood flow. The authors applied this procedure, which can be repeated at very short intervals, twice in 5 patients suffering from schistosomiasis, and in 6 controls. The percentage of deviation from the mean was calculated by means of two measurements performed in each individual, and was less than 10% in 63.6% of the cases. Higher variations up to 30% can be attributed either to irregular liver perfusion or to oscillations due to emotional distress of the waking subject. The mean value obtained in normal control subjects was 46.7 ml/min per 100 g liver weight. No significant difference was seen between the mean values obtained in patients suffering from schistosomiasis and in the controls. The use of inert gases presents considerable advantages such as rapid diffusion and immediate elimination. However, the varying degree of fatty degeneration with its corresponding changes in the distribution coefficient between gas and tissue, restricts the use of this method in hepatic disorders.

Adult↗
PubMed1976

Copper and ceruloplasmin contents in the blood serum of peripheral and pre-hepatic veins.

Cooper and ceruloplasmin contents were determined in samples of peripheral and pre-hepatic venous blood of 11 patients with Manson's schistosomiasis and one patient with hepatolenticular degeneration, all of çhich submitted either to porto-caval or spleno-renal shunt. Individual difference were not significant in any of the non-Wilsonian patients. The results are discussed in regard to the current knowledge on the pathogenesis of Wilson's disease.

Ceruloplasmin↗