Biomedical subjects

S Repse

Publications and source records attributed to S Repse.

22 records · Page 2Linked to original sources

PubMedDate not supplied

Lymph node metastases in gastric cancer: correlation between new and old UICC TNM classification.

The 5th edition of TNM classification (1997) grades lymph node involvement in gastric cancer by the number of metastatic lymph nodes. Their prognostic significance as defined by the new (5th edn., 1997) and old (4th edn., 1987) TNM classification was evaluated and survival in pN categories between both versions was compared. It was demonstrated in our analysis that comparison of old and new TNM systems is possible. Categories pN1 and pN2 contain patients selected by different criteria in both versions of TNM classification but with similar survival probabilities. Anatomic location of lymph nodes as described in the 4th edn. and number of involved nodes in the 5th edn. of TNM classification have about the same prognostic value in categories pN1 and pN2. The advantage of the 5th edn. is the identification of a group of patients (pN3, >15 involved lymph nodes) with significantly poor prognosis, which, in our series, includes 15% of R0 resected patients with lymph node metastases.

Gastrectomy↗

PubMedDate not supplied

Comparison of Lauren's, Ming's and WHO histological classifications of gastric cancer as a prognostic factor for operated patients.

The prognostic significance of the above mentioned histological classifications is evaluated. The survival data of 259 supposedly radically resected patients is analyzed. The survival curves have been calculated according to the Kaplan-Meier method and compared with the Mantel-Cox test. The most important prognostic factors have been found and used in the stratification analysis. The diffuse type of cancer (according to Lauren) has significantly worse prognosis than the intestinal type only considering the same pT (pT3) and sex (male) or age group from 50 to 70 years. The infiltrative type of cancer (according to Ming) has a worse prognosis than expansive. The difference is insignificant even after stratification analysis. Worse prognosis of diffuse (or infiltrative) cancer is influenced more by the infiltration of regional lymph nodes than by the depth of infiltration, age or sex. WHO classification is less important as a prognostic factor. Signet ring cell type cancer has a worse prognosis considering age group 50-70 years.

Female↗

PubMedDate not supplied

Emergency colorectal surgery: our results and complications.

BACKGROUND: Emergency surgery for obstruction, perforation and massive bleeding represent 10%-40% of all colorectal operations. METHODS: Retrospective analysis of a series of 170 patients operated on in the period from 1.1.1988 to 31.12.1993. RESULTS: 170 (12.5%) of 1363 patients with colorectal pathology needed urgent surgery: 121 (71.2%) for obstruction, 39 (22.9%) for perforation and 10 (5.9%) for massive bleeding, with mortality rate 17.6% (30 patients). 116 (68.2%) underwent one-stage procedure with mortality rate 9.5% (11 patients), 36 (21.2%) patients underwent two-stage procedure with mortality rate 27.8% (10 patients) and 18 (10.6%) patients other procedures. 115 (67.7%) of 170 patients had malignant disease; 92/115 (80.0%) underwent one-stage procedure with mortality rate 10.9% (10 patients), 7 (6.1%) patients two-stage procedure with mortality rate 14.3% (1 patient) and 16 (13.9%) other palliative procedures (by bass, stoma). CONCLUSION: We believe one-stage procedure is the method of choice for the most colorectal emergencies.

Adult↗

PubMedDate not supplied

Outcome after emergency subtotal/total colectomy compared to elective resection in patients with left-sided colorectal carcinoma.

Long term survival of 72 patients who underwent an emergency one-stage subtotal/total colectomy with primary anastomosis for obstructing carcinoma of the left colon was compared with 141 patients who underwent an elective procedure for non-obstructing carcinoma of the same location. Patients who presented with intestinal obstruction were older than electively treated patients (68.5 versus 62.1 years), postoperative mortality was higher (13.8% versus 7.8%). 5-year survival rate of patients treated by R0 emergency subtotal/total colectomy was comparable to electively R0 resected patients (69% versus 61%). There was no significant difference in survival comparing the same Dukes' stage between the two groups. One-stage procedure could be regarded as a preferred method of treatment in patients with obstructing carcinoma of the left colon, either as a subtotal/total colectomy in cases when the colonic wall is endangered or as a resection with primary colo-colonic anastomosis after on-table lavage.

Adult↗