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Biomedical subjects

S S Grigorian

Publications and source records attributed to S S Grigorian.

61 records · Page 4Linked to original sources
PubMedDate not supplied

[The level of the eosinophils in the blood, serum immunoglobulins and circulating immune complexes and interferon production in patients with unilocular echinococcosis depending on the location of the cysts].

The correlations between blood eosinophils, serum immunoglobulins (Ig), circulating immune complexes (CIC) content, alpha- and gamma-interferon (IFN) production and HLA class I antigens were analyzed in 33 patients with hydatid disease aged 37.5 +/- 1.5 years. Direct correlation between the activity of gamma-IFN production, blood eosinophils, IgG and specific IgE content was found in patients with multiple pulmonary damage. In this group the high level of CIC correlated with the high content of IgG and specific IgE. In patients with solitary and multiple cysts in the liver in spite of high alpha- and gamma-IFN production the levels of total and specific IgE were low, IgG and CIC contents were moderate and eosinophils percent was low. In patients with combined damage of the liver and multiple cysts in the abdominal cavity high CIC production correlated directly with high total IgE content. In the total group of patients percent of HLA B5 carriers was significantly higher than in controls: 36.6 and 14.7 respectively (R = 0.01 after Fischer) that correlated with comparatively active gamma-IFN production in patients with the pulmonary and the liver cysts. The possible explanation of the different immune response in patients with the different localisation of the parasite cysts are discussed.

Adolescent↗
PubMedDate not supplied

[The action of high-molecular linear polymers on the circulatory system].

An analysis of the hemodynamic consequences of the injections of long linear polymers with high molecular weight is introduced. These injections lead to an increase of the cardiac output, to a decrease of the blood pressure, and hence cause a reduction of the resistance to blood flow. It follows that such kind of polymers is able to normalize hemodynamics under some pathophysiological conditions, e.g., during experimental atherosclerosis, ischemic state, hemorrhagic shock. An addition of drag-reducing polymers into the blood system is associated with a modification of the blood flow microstructure itself.

Animals↗
PubMedDate not supplied

[Disorders in the interferon system in patients with virus-associated and chlamydial infections].

A more than 80% incidence of herpes simplex virus, cytomegalovirus, and chlamydial infection was revealed in 58 patients with various gynecological diseases. In 50% cases the infection was mixed. An appreciable reduction of the gamma-interferon system was detected in 20 patients, which was caused by a concomitant infectious process, possibly provoking the development of the underlying disease. Treatment of such patients should include antiviral and antichlamydial therapy, as well as correction of defects in interferon production.

Adult↗
PubMedDate not supplied

[Response of the hypothalamic neurons to stimulation of the vestibular nerve and lateral vestibular nucleus in rabbits].

Effects of single, double, and rhythmic stimulation upon hypothalamic neurons responding to the 1st excitatory phase of lateral vestibular nucleus stimulation, were studied. The data obtained show that activation of some hypothalamic neurons following stimulation of the lateral vestibular nucleus has a monosynaptic character. The findings suggest that ascending afferents from the lateral vestibular nucleus to the hypothalamus pass via oligo- as well as polysynaptic pathways.

Afferent Pathways↗