Biomedical subjects
Publications and source records attributed to S S Kraman.
When a patient is harmed by an error or negligence, hospitals tend to treat the patient as a threat. There is now theoretical and experiential evidence that full-disclosure, apology and fair compensation may protect all parties at lower cost.
With the emerging use of tracheal sound analysis to detect and monitor respiratory tract changes such as those found in asthma and obstructive sleep apnea, there is a need to link the attributes of these easily measured sounds first to the underlying anatomy, and then to specific pathophysiology. To begin this process, we have developed a model of the acoustic properties of the entire respiratory tract (supraglottal plus subglottal airways) over the frequency range of tracheal sound measurements, 100 to 3000 Hz. The respiratory tract is represented by a transmission line acoustical analogy with varying cross sectional area, yielding walls, and dichotomous branching in the subglottal component. The model predicts the location in frequency of the natural acoustic resonances of components or the entire tract. Individually, the supra and subglottal portions of the model predict well the distinct locations of the spectral peaks (formants) from speech sounds such as /a/ as measured at the mouth and the trachea, respectively, in healthy subjects. When combining the supraglottic and subglottic portions to form a complete tract model, the predicted peak locations compare favorably with those of tracheal sounds measured during normal breathing. This modeling effort provides the first insights into the complex relationships between the spectral peaks of tracheal sounds and the underlying anatomy of the respiratory tract.
This article describes one hospital's development of a proactive, patient centered program, which emphasizes total honesty in dealing with all aspects of patient care. This process includes the full and timely disclosure of errors which affect the patient's health and well being. The article describes the process by which the medical facility identifies errors and works with healthcare providers to arrive at a consensus on the management of these errors. Included is a step by step analysis of how disclosure can be successfully accomplished.
This paper reviews a humanistic risk management policy that includes early injury review, steadfast maintenance of the relationship between the hospital and the patient, proactive full disclosure to patients who have been injured because of accidents or medical negligence, and fair compensation for injuries. The financial consequences of this type of policy are not yet known; however, one Veterans Affairs medical center, which has been using humanistic risk management since 1987, has had encouragingly moderate liability payments. The Department of Veterans Affairs now requires such a policy for all of its facilities; therefore, comprehensive experience may be only a few years away.
The effect of ambient sounds, generated during breathing, that may reach a sensor at the chest surface by transmission from mouth and nose through air in the room, rather than through the airways, lungs and chest wall, is studied. Five healthy male non-smokers, aged from 11 to 51 years, are seated in a sound-proof acoustic chamber. Ambient respiratory noise levels are modified by directing expiratory flow outside the recording chamber. Low-density gas (HeO2 = 80% helium, 20% oxygen) is used to modify airway resonances. Spectral analysis is applied to ambient noise and to respiratory sounds measured on the chest and neck. Flow-gated average sound spectra are compared statistically. A prominent spectral peak around 960 Hz appears in ambient noise and over the chest and neck during expiration in all subjects. Ambient noise reduction decreases the amplitude of this peak by 20 +/- 4 dB in the room and by 6 +/- 3.6 dB over the chest. Another prominent spectral peak, around 700 Hz in adults and 880 Hz in children, shows insignificant change, i.e. a maximum reduction of 3 dB, during modifications of ambient respiratory noise. HeO2 causes an upward shift in tracheal resonances that is also seen in the anterior chest recordings. Ambient respiratory noise explains some, but not all, peaks in the spectra of expiratory lung sounds. Resonance peaks in the spectra of expiratory tracheal sounds are also apparent in the spectra of expiratory lung sounds at the anterior chest.
The spectra of sounds recorded over the trachea of adults typically reveal peaks near 700 and 1500 Hz. We assessed the anatomical determinants of these peaks and the conditions contributing to their presence. We studied five adult subjects with normal lung function, measuring sounds at the suprasternal notch and on the right cheek. The subjects breathed at target airflows of 15 and at 30 ml sec(-1) kg(-1) both through the mouth with nose clips and then through the mouth and nose using a cushioned face mask. The mouth breathing maneuvers were performed with three lengths (3.6, 21.1 and 38.6 cm) of 2.6 cm diameter tubing between the mouth and the pneumotachograph. The nose breathing maneuver was performed with the longest tube (between the mask and pneumotachograph). The signals occurring at the target flows +/- 20% were used to create averaged, spectral estimates. We found that all subjects had two predominant spectral peaks; a approximately 700 Hz peak loudest over the cheek and a approximately 1500 Hz peak loudest over the trachea. The frequency of both peaks negatively correlated with body height (and presumably, airway length). There was no systematic effect of breathing phase, flow rate or length of the tube connecting the mouth to the pneumotachograph on the spectral peaks. Breathing into the mask and breathing through the nose did markedly alter the spectra. We conclude that the higher tracheal sound peak reflects resonance within the major airways and is relatively independent of extrathoracic influences during mouth breathing through a tube.
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STUDY OBJECTIVE: We have previously investigated the effects of microphone type and coupler air chamber depth on lung sound characteristics. We now report the results of experiments exploring the effects of air chamber width, shape, and venting on lung sounds. DESIGN: We used a single electret microphone with a variety of plastic couplers. The couplers were identical except for the diameter and shape of the air chamber. We used cylindrical chambers of 5, 10, and 15 mm in diameter at the skin and conical chambers of 8, 10, and 15 mm in diameter. We compared the inspiratory lung sound spectra obtained using each of the couplers. We also examined the tendency of various needle vents to transmit ambient noise into the microphone chamber. SETTING: Anechoic chamber. MEASUREMENTS AND RESULTS: The shape and diameter had little important effect on the lung sound spectrum below 500 Hz. From approximately 500 to 1,500 Hz, the 5-mm diameter couplers showed slightly less sensitivity than the 10- and 15-mm diameter couplers. All conical couplers provided approximately 5 to 10 decibel more sensitivity than the cylindrical couplers. All vents allowed some ambient noise to enter the chamber but the amount was trivial using the narrowest, longest vent. CONCLUSIONS: These data suggest that the optimal electret microphone coupler chamber for lung sound acquisition should be conical in shape, between 10 and 15 mm in diameter at the skin, and either not vented or vented with a tube no wider than 23-g or shorter than 20 mm.
Sonic noise transmission from the mouth to six sites on the posterior chest wall is measured in 11 healthy adult male subjects at resting lung volume. The measurement sites are over the upper, middle and lower lung fields and are symmetric about the spine. The ratios of transmitted sound power to analogous sites over the right (R) and left (L) lung fields are estimated over three frequency bands: 100-600 Hz (low), 600-1100 Hz (mid) and 1100-1600 Hz (high). A R-L dominance in transmission is measured at low frequencies, with a statistically significant difference observed at the upper site. No significant asymmetry is observed in any measurement site at mid or high frequencies. A theoretical model of sound transmission that includes the asymmetrical anatomy of the mediastinal structures is in agreement with the observed asymmetry at low frequencies. These findings suggest that the pathway of the majority of sound transmission from the trachea to the chest wall changes from a more radial to airway-borne route over the measured frequency range.
The use of electret microphones to measure lung sounds is widespread because of their small size, high fidelity, and low cost. Typically, an air cavity is placed between the skin surface and the microphone to convert the chest wall vibrations into a measurable sound pressure. The importance of air cavity depth on this transduction process was investigated in this study. An acoustic model of chest wall--air cavity--microphone interface was developed and the predicted effects of depth were compared with measurements performed using an artificial chest wall and lung sounds from a healthy subject. Model predictions are in general agreement with both in vitro and in situ measurements and indicate that the overall high-frequency response of the transduction diminishes with increasing cavity depth. This finding suggests that smaller cavity depths are more appropriate for detection of lung sounds over a wide band width and stresses the importance of coupler size on microphone measurements.
We assessed the performance of three air-coupled and four contact sensors under standardized conditions of lung sound recording. Recordings were obtained from three of the investigators at the best site on the posterior lower chest as determined by auscultation. Lung sounds were band-pass filtered between 100 and 2,000 Hz and sampled simultaneously with calibrated airflow at a rate of 10 kHz. Fourier techniques were used for power spectral analysis. Average spectra for inspiratory sounds at flows of 2 +/- 0.5 L/s were referenced against background noise at zero flow. Air-coupled and contact sensors had comparable maximum signal-to-noise ratios and gave similar values for most spectral parameters. Unexpectedly, less sensitivity (lower signal-to-noise ratio) at high frequencies was observed in the air-coupled devices. Sensor performance needs to be characterized in studies of lung sounds. We suggest that lung sound spectra should be averaged at known airflows over several breaths and that all measurements should be reported relative to sounds recorded at zero flow.
Auscultatory percussion is a technique that is potentially useful to study the acoustic behaviour of the chest. However, finger percussion, as used in this technique, has not been previously assessed for consistency. We calculated the intrasubject variability and short-term reproducibility of this technique in 10 healthy subjects. We examined several indices of the output sound of two series of sternal percussion manoeuvres performed one hour apart by the same examiner. The results were compared to those obtained during sternal percussion performed by a mechanical thumper. Consistency for both finger and thumper percussion varied from 4.8-20.6 (coefficients of variation) for various acoustic indices. For thumper percussion, the average results were not significantly different from those of finger percussion. We conclude that finger percussion of the sternum is sufficiently consistent to be used as a tool to investigate the acoustic behaviour of the chest.
We examined the distribution of airflow-generated sound within a flexible model of canine airways. Sounds were picked up by a microphone adapted to a glass conical probe which was introduced through puncture holes in the wall of the model. We acquired 341 measurements in 31 airways between 2.0 and 19.0 mm in diameter at airflow rates from 0 to 2.5 L/s in the inspiratory and expiratory directions. We found that in the expiratory direction, the sound amplitude was approximately linearly related to airway cross-sectional area, with the greatest amplitude occurring in the largest airway. In the inspiratory direction the greatest amplitude occurred in airways of 5 to 8 mm in diameter. At all levels within the model, sound amplitude was approximately linearly related to the square of the airflow. Our findings suggest that in canine airways, the predominant vesicular lung sound-producing locations are the large airways for the expiratory component and the medium-sized airways for the inspiratory component.
Auscultatory percussion of the chest is a clinical examination method that has been purported to detect intrapulmonary masses by their effect on transmission of the percussion note to the posterior chest. Recent findings from this laboratory suggested that the sound of sternal percussion may actually travel through the chest cage and not the lung parenchyma. To investigate this possibility further, we recorded the sound produced by sternal percussion at 63 evenly spaced points over the posterior chest wall of 3 healthy subjects and 4 patients with large, discrete intrathoracic lesions in the right upper lobe (2 patients), left lower lobe, and left upper lobe (1 patient each). We constructed 3-dimensional contour maps of the indices of sound amplitude and frequency to view graphically the pattern of distribution of the sound. Examination of the maps revealed areas of increased amplitude in the zones of projection of some osseous structures, especially the scapulae, both in the healthy subjects and patients. No disturbances in the pattern reflecting the presence of mediastinal structures or intrathoracic lesions were found despite the existence of deeply situated lung masses as large as 10 cm in diameter. These findings support the argument that the sound of sternal percussion travels to the posterior chest predominantly through chest wall structures.
We indirectly determined the transmission path of sound generated by sternal percussion in five healthy subjects. We percussed the sternum of each subject while recording the output audio signal at the posterior left and right upper and lower lung zones. Sound measurements were done during apnea at functional residual capacity, total lung capacity, and residual volume both with the lungs filled with air and with an 80% He-20% O2 (heliox) gas mixture. Three acoustic indexes were calculated from the output sound pulse: the peak-to-peak amplitude, the peak frequency, and the mid-power frequency. We found that the average values of all indexes tended to be greater in the upper than in the ipsilateral lower lung zones. In the upper zones, peak-to-peak amplitude was greater at total lung capacity and residual volume than at functional residual capacity. Replacing air with heliox did not change these results. These experiments, together with others performed during Mueller and Valsalva maneuvers, suggest that resonance of the chest cage is the predominant factor determining the transmission of sternal percussion sounds to the posterior chest wall. The transmission seems to be only minimally affected by the acoustic characteristics of the lung parenchyma.
We examined the transmission to the chest wall of white noise and 25-Hz square-wave-generated noise introduced at the mouth of five healthy subjects. The output audio signals were recorded over the left and right upper and lower lung zones, posteriorly. Sound measurements were made during apnea at functional residual capacity, total lung capacity, and residual volume both after breathing air and an 80% He-20% O2 (heliox) gas mixture. We calculated the peak-to-peak amplitude, the peak frequency, and the midpower frequency of the output sound. We found no consistent variations in the values of these indexes due to lung volume or resident gas density. In all cases, the transmitted sound was most intense at the right upper zone. This could not be explained on the basis of technical factors but was probably the result of normal asymmetry of the mediastinal anatomy. These data suggest that sound introduced through the mouth of healthy individuals excites intrathoracic structures but is transmitted through the parenchyma in such a manner that it is not markedly affected by familiar physiological variables. This must be taken into account if objective acoustical tests of lung physiology are to be developed.
If the lung is an elastic continuum, both longitudinal and transverse stress waves should be propagated in the medium with distinct velocities. In five isolated sheep lungs, we investigated the propagation of stress waves. The lungs were degassed and then inflated to a constant transpulmonary pressure (Ptp). We measured signals transmitted at locations approximately 1.5, 6, and 11 cm from an impulse surface distortion with the use of small microphones embedded in the pleural surface. Two transit times were computed from the first two significant peaks of the cross-correlation of microphone signal pairs. The "fast" wave velocities averaged 301 +/- 92, 445 +/- 80, and 577 +/- 211 (SD) cm/s for Ptp values of 5, 10, and 15 cmH2O, respectively. Corresponding "slow" wave velocities averaged 139 +/- 22, 217 +/- 36, and 255 +/- 89 cm/s. The fast waves were consistent with longitudinal waves of velocity [(K + 4G/3)/p]1/2, where bulk modulus K = 4 Ptp and shear modulus G = 0.7 Ptp. The slow waves were consistent with transverse (and/or Rayleigh) waves of velocity (G/p)1/2, with a G value of 0.9 Ptp. Measured values of K were 5 Ptp and values of G measured by indentation tests were 0.7 Ptp. Thus, stress wave velocities measured on pleural surface of isolated lungs correlated well with elastic moduli of lung parenchyma.
A method of producing flexible and strong models of canine airways is described. The animal's lungs are dried in inflation by using compressed air and then filled with silicone sealer. After this compound dries, the lung tissue is removed by corrosion by using NAOH. The result is a rugged, flexible, and anatomically faithful model of canine airways that is suitable for use in teaching.