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S Sacks

Publications and source records attributed to S Sacks.

At least 73 records · Page 4Linked to original sources

Analysis of cohort effects from cross-sectional data.

A statistical model and computer program are described to analyze data fro the existence of cohort effects. The analysis leads to the separate assessments of cohort, time and age influences on a series of age-specific rates that are available in cross-sectional form. The assessment of these three factors can possibly yield insights into specific disease etiologies.

Age Factors↗

Aseptic meningitis as a complication of scinticysternography utilizing 111Indium-dtpa.

The intrathecal administration of numerous substances has been known to cause arachnoiditic as well as aseptic meningitic reactions. Pleocytosis and increased protein in the CSF are well known findings following administration of air or myelographic dyes. This has also been observed with antibiotics. Even intrathecal steroids (e.g. depo-medrol) have been implicated in aseptic meningitic reactions. Despite the wide variety of causative agents, only a small percentage of patients develop clinical manifestations of aseptic meningitis. Are these reactions then caused by specific auto-immune type responses, or are they directly related to local irritants in each case, or a combination of both factors?

Female↗

Chronic Gaucher's disease: radiological findings in 17 South African cases.

This paper reports radiological findings in a series of 17 South African patients with chronic (adult or non-neuronopathic) Gaucher's disease. Osteoarticular signs are briefly analysed on the basis of their pathogenesis. The visceral findings included an enormous calcified spleen and three cases with pulmonary lesions. Important advances have been made recently in diagnosing. Gaucher's disease and detecting carriers by demonstration of deficiency of beta-glucosidase. Radiographs are not diagnostic, but they may provide valuable clues to the nature and extent of lesions in bone, and they are essential in orthopaedic management of Gaucher's disease.

Adolescent↗